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FRENCH INFRASTRUCTURE FOR INTEGRATED STRUCTURAL BIOLOGY

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AFMB

CRYO ELECTRON MICROSCOPY

The methods of X-ray crystallography and NMR spectroscopy can provide detailed information on molecular structure and dynamics. At the cellular level, optical microscopy reveals the spatial distribution and dynamics of molecules tagged with fluorophores. Electron microscopy (EM) overlaps with these approaches, covering a broad range from atomic to cellular structures. The development of cryogenic methods has enabled EM imaging to provide snapshots of biological molecules and cells trapped in a close to native, hydrated state.

The platform is equipped with an electron microscope FEI Tecnai operating at 120 kV. This equipment is used to assess the feasibility of the projects and to refine the experimental procedures. We have also access to the Tecnai G2 F20 of the Institute (IFR 48, Marseille, Maladies infectieuses)

For more information seeĀ http://www.afmb.univ-mrs.fr/electron-microscopy