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FRENCH INFRASTRUCTURE FOR INTEGRATED STRUCTURAL BIOLOGY

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INSTRUCT CENTRE - FRANCE 2 - ISBG

HIGH-THROUGHPUT CRYSTALLISATION

The High Throughput crystallization platform at the EMBL Grenoble Outstation ( the HTX Lab),  offers automated crystallization services to local researchers in the context of the Grenoble Partnership for Structural Biology (PSB) and to  European researchers through the EC-funded project P-CUBE. It is also actively involved in the development of new concepts and methods in macromolecular crystallization. The HTX lab is one of the largest crystallization facilities in Europe and  is located next to the European Synchrotron Radiation Facility (ESRF) and the Institute Laue Langevin (ILL).

We offer automated vapour diffusion crystallization screening in hanging and sitting drop set up at two temperatures ( 20 deg and 5 deg ). Access to the results is provided through the web-based Crystallization Information Management System (CRIMS), which includes fast and convenient interfaces for the evaluation and annotation of experiments. Crystallization plates containing crystals are made available to users upon requests (typically during their next synchrotron visit) and facilities for crystal mounting and freezing are provided. Since the beginning of operations in 2003, the HTX lab has provided crystallisation screening services to over 400 scientists resulting in more than 4 million individual crystallization experiments.

Comment: Access to this platform is funded via Biostruct-X. French labs are invited to apply at http://www.biostruct-x.eu/ for funding.

See more at:

http://www.structuralbiology.eu/resources/platforms/embl-grenoble-psb/high-throughput-crystallisation-laboratory-embl-grenoble