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FRENCH INFRASTRUCTURE FOR INTEGRATED STRUCTURAL BIOLOGY

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TRAINING COURSE

MXIS 2017 Practical course on in-plate crystallography, with special focus on ligand screening Part2

November 29 - December 1, 2017
IBS Grenoble

The MXIS training course is dedicated to in situ protein crystallography, with a special emphasis on ligand screening. This workshop is organized in two parts, each one lasting for 3 days. It includes:<o:p></o:p>

·         Part 1 (Montpellier): full lectures at the “Centre de Biochimie Structurale” followed by practicals. Topics: plate pre-coating for “Dry” co-crystallization [1], in situ screening on a lab source).<o:p></o:p>

·         Part 2 (Grenoble): full lectures at the “Institut de Biologie Structurale” and practical sessions at the ESRF, on beamlines FIP-BM30A and ID30B. Full classes will be done in day 1 while practical sessions will be organized in subgroups, from day 2 to day 3. Topics: in situ diffraction for crystal screening and structure resolution, in situ data processing.<o:p></o:p>

Possibility will be given to participants to practice on their own samples. A fragment library may be available to be used on your sample (to be confirmed later on)<o:p></o:p>

The workshop is limited to 6 and 8 participants for Part 1 and 2 respectively.<o:p></o:p>

No fees are required.<o:p></o:p>

The application period will close on the 8th of October. Applicants will be required to submit a short CV and a motivation letter to jean-luc.ferrer@ibs.fr <o:p></o:p>

More information on https://workshops.ibs.fr/MXIS-2017  (in construction)<o:p></o:p>

[1] Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Gelin M, Delfosse V, Allemand F, Hoh F, Sallaz-Damaz Y, Pirocchi M, Bourguet W, Ferrer JL, Labesse G, Guichou JF. Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1777-87. doi: 10.1107/S1399004715010342.<o:p></o:p>

https://workshops.ibs.fr/workshop-mxis-2017

Download flyer_MXIS2017.pdf