High pressure (spectrophotometer, fluorimeter, crystallography)
Four high-pressure thermo-regulated instruments are now available at the IBS. They consist of a spectrofluorimeter, an UV/visible spectrophotometer, a high-pressure steel vessel with a maximum pressure of 8 kbar and a gel electrophoresis system under high hydrostatic pressure. They allow to characterise the stability and activity of biological systems as a function of pressure (up to 4 or 5 kbar), to study the dissociating and denaturant effects of pressure (up to 8 kbar) and to measure stability. Pressure can also be used to promote and trap conformational states of the macromolecules.
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