Our NMR platform is dedicated to the structural and functional characterization of proteins at atomic resolution as well as drug discovery.
Applications: We provide expertise in protein structure determination, dynamics analysis, and interaction studies, including protein–protein, protein–peptide, and protein–nucleic acid complexes. We also have expertise in using high-pressure NMR to study protein folding or identify binding pockets. Finally, we offer NMR-based fragment screening and ligand validation to accelerate early-stage drug discovery and guide structure-based optimization.
Equipment: The platform is equipped with a 800 MHz Bruker Avance spectrometer and a 700 MHz Bruker Avance spectrometer.
Description: The 800 MHz Bruker Avance spectrometerisequipped with a 5mm cryogenic probe (triple-resonance proton detection, carbon, nitrogen).The700 MHz Bruker Avance spectrometeris equipped with a 5mm cryogenic probe (triple-resonance proton detection, carbon, nitrogen). For High-pressure NMR, the spectrometers can be coupled to a high-pressure device, allowing sample pressure to be varied precisely from 0 to 3 kbar for all probes.
