Our NMR platform is dedicated to the structural and functional characterization of proteins at atomic resolution:
We provide expertise in:
- protein structure determination, dynamics analysis, and interaction studies, including protein–protein, protein–peptide, and protein–nucleic acid complexes.
- We also have expertise in using high-pressure NMR to study protein folding or identify binding pockets.
- Finally, we offer NMR-based fragment screening and ligand validation to accelerate early-stage drug discovery and guide structure-based optimization.
The platform is equipped with:
- 800 MHz Bruker Avance spectrometer: equipped with a 5mm cryogenic probe (triple-resonance proton detection, carbon, nitrogen).
- 700 MHz Bruker Avance spectrometer: equipped with a 5mm cryogenic probe (triple-resonance proton detection, carbon, nitrogen).
- High-pressure NMR: The spectrometers can be coupled to a high-pressure device, allowing sample pressure to be varied precisely from 0 to 3 kbar for all probes.