NAME OF SERVICE : Characterization of intact biomolecules and macromolecular complexes in native conditions
Description of instrument : High resolution Mass spectrometers
Application :
–Determination of the mass of intact proteins, peptides and small molecules;
-Control of protein and peptide expression, modification, mutation and labeling;
-Analysis and characterization of macromolecular complexes by native mass spectrometry.
Equipment :
- MALDI-TOF/TOF Autoflex maX, Bruker Daltonics (linear and reflectron mode), up to 500kDa
- HPLC ESI-QTOF 6545XT, Agilent Technologies, resolution > 40’000
- High mass ESI Q-TOF MS Ultima (Micromass Waters) modified by MSvision for Native mass spectrometry
Description : Our platform specializes in the analysis of biomolecules in their intact form, without enzymatic digestion.Native mass spectrometry allows stoichiometry determination of macromolecular complexes and characterization of their interaction dynamics.
Website: https://www.isbg.fr/mass-spectrometry/
