TRAINING

FRISBI offers a range of workshops to train graduate and post-graduate students in integrated structural biology. FRISBI courses are open to french and european researchers, from academic and industry.

ReNaFoBis / FRISBI webinar

Next FRISBI/ReNaFoBis webinar February 13, 2025 at 01 pm.

Speaker: Tobias Madl University of Graz, Austria

Tittle "Decoding the Regulatory Role of Post-Translational Modifications with NMR Spectroscopy"

Post-translational modifications (PTMs) are critical regulators of protein function, enabling dynamic control over processes such as RNA processing, signal transduction, and condensate formation. These modifications often play pivotal roles in physiology and diseases, yet their molecular mechanisms remain elusive in many cases. In this webinar, I will demonstrate how Nuclear Magnetic Resonance (NMR) spectroscopy serves as a powerful tool for unraveling the complex role and interplay of PTMs at the molecular level.  
The presentation will begin with an introduction to NMR spectroscopy toolbox to study PTMs, providing a foundation for understanding how this technique is applied in these studies. I will then explore key methodologies for introducing post-translational modifications into proteins for NMR analysis, identifying modification sites, and determining modification kinetics. Additionally, I will highlight how NMR can reveal the intricate interplay between different modifications, particularly in the context of intrinsically disordered proteins.  
Using arginine methylation and phosphorylation as examples, I will illustrate how these PTMs modulate biological processes, with specific case studies on their roles in RNA processing, signal transduction, and biomolecular condensate formation. These examples will underscore the critical regulatory functions of PTMs in both physiological and pathological contexts and demonstrate how NMR provides unparalleled insights into their molecular dynamics and interactions.  
By the end of the webinar, attendees will gain a deeper appreciation for how NMR spectroscopy enables the study of PTMs, offering valuable perspectives for advancing research in protein biochemistry and understanding diseases associated with dysregulated modifications.  

Please register here https://cnrs.zoom.us/meeting/register/O43Q26AcRgOGAO4F96pCYQ

 

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FRISBI support BioStine a site to access the basics in Structural Biology https://www.biostine.fr/

Une play-list youtube dédiée à la Biologie Structurale Intégrative (Coordination: Marie-Hélène Le Du, Paris-Saclay): https://www.youtube.com/playlist?list=PLJXFANNaperht_5i-UzBTvCLAH0-CbIg6

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Past webinars:

Please follow our program of ReNaFoBis-FRISBI webinars

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FRISBI is involved and strongly support the French National training network in structural biology (ReNaFoBiS).  Aimed to be a national PhD training network, ReNaFoBiS coordinate and organize classes, workshops and training programs for students and post-docs.

See http://www.renafobis.fr/   for more information