TRAINING

FRISBI offers a range of workshops to train graduate and post-graduate students in integrated structural biology. FRISBI courses are open to french and european researchers, from academic and industry.

ReNaFoBis / FRISBI webinar

Please find below the program of the next FRISBI/ReNaFoBis webinar on October 16^th at 01:00 PM Paris with 2 speakers

Speaker : Philippe Carpentier: Laboratoire de Chimie et Biologie des Métaux, DRF/IRIG/CBM, UMR 5249 CEA/CNRS/UGA, CEA/Grenoble, 17, Rue des Martyrs, Grenoble 38000, France Visiting Scientist at the European Synchrotron Radiation Facility, Grenoble 38000, France Title: Pressurizing crystals at the HPMX laboratory to unlock the internal architecture, dynamics, and mechanisms of proteins

Abstract:
This presentation will introduce the High-Pressure Macromolecular Crystallography (HPMX) laboratory at the ESRF, dedicated to studying interactions between macromolecules and gases in crystals. With more than 240’000 structures deposited in the PDB, only approximately 1,500 contain biologically relevant gases, which often play functional roles. While some proteins crystallize naturally with these gases, many require pressure for their introduction into crystals. The HPMX laboratory is equipped with different cryogenic high-pressure cells for gases such as He, Ar, Kr, Xe, N₂, O₂, CO₂, and CH₄, supporting research in biology, biochemistry, medicine, and environmental sciences. High-pressure cryo-cooling enables crystals to be frozen without the use of cryoprotectants and stabilizes protein-gas complexes through a three-step process: soaking crystals under pressurized gas, rapid cooling under pressure, and recovery after depressurization at cryogenic temperatures. Applications include noble-gas derivatization to map protein internal architecture (pockets, tunnels, channels), investigation of catalytic mechanisms in gas-utilizing enzymes, and analysis of pressure-induced structural changes or conformational dynamics. Examples of HPMX applications will be presented, illustrating the versatility and capabilities of the technique. The laboratory continues to evolve by developing original gas pressure cells to address new scientific questions.

AND

Speaker: Mael Balanec: I2BC Paris Saclay Title: Structural understanding of site-specific recombination by XerC/XerD in Vibrio cholerae"

Please register here https://us06web.zoom.us/webinar/register/WN_QPAGVvrvSz-a0cUhoZMBYg

 

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BioStine

FRISBI support BioStine a site to access the basics in Structural Biology in French Biostine FR , or in English Biostine EN

Une play-list youtube dédiée à la Biologie Structurale Intégrative (Coordination: Marie-Hélène Le Du, Paris-Saclay): https://www.youtube.com/playlist?list=PLJXFANNaperht_5i-UzBTvCLAH0-CbIg6

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Past webinars:

September 18 Speaker: Darren Hart, IBS/ISBG Grenoble Title: The French Infrastructure for Integrated Structural Biology (FRISBI) - current status and future plans.

July 10^th at 01:00 PM Paris Leandro Estrozi, IBS, Grenoble Title: Helical Symmetry Determination for 3D Cryo-Electron Microscopy and Denis Chrétien, Université de Renes Title: C- and D-type lateral interactions weaken the microtubule lattice

May 15^th at 01:00 PM Paris  Marc Jamin, IBS, Grenoble, France Tittle: Deciphering the mechanisms of liquid phase separation induced by rabies virus phosphoprotein

April 24 at 01:00 PM Paris Speaker: Simon Pichard, IGBMC/CBI, Illkirch, France Tittle: Eukaryotic production and characterization of multi-protein complexes: tools and examples and Speaker: Amélie Zachayus, IGBMC, France Title: New Models, New Insights: How CRISPR-Cas9 and Live-Cell Analysis can be used to Enhance Our Understanding of Cellular Mechanisms: the example of the transcription/DNA repair factor TFIIH

Please follow our program of ReNaFoBis-FRISBI webinars

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FRISBI is involved and strongly support the French National training network in structural biology (ReNaFoBiS).  Aimed to be a national PhD training network, ReNaFoBiS coordinate and organize classes, workshops and training programs for students and post-docs.

See http://www.renafobis.fr/   for more information