TRAINING

FRISBI offers a range of workshops to train graduate and post-graduate students in integrated structural biology. FRISBI courses are open to french and european researchers, from academic and industry.

ReNaFoBis together with FRISBI will organize a webinar:

December 12, 2024 at 01pm: 2 speakers

Short presentation of the Biophysics working group followed by 2 presentations :

Marta Janczuk-Richter, Creoptix AG, Wädenswil, Switzerland Title: Pushing the boundaries in biomolecular interaction analysis with the Creoptix WAVEsystem

Summary: Grating-coupled interferometry (GCI) is surface-based, label-free biosensing technology that offers the highest sensitivity and crude sample robustness over a broad range of applications.
The Creoptix WAVEsystem combines the enhanced sensitivity of GCI technology with an innovative, fast-transition fluidics architecture and no-clog WAVEchips. A wide range of molecules can be immobilized using various chemistries or capturing techniques, while remaining compatible with crude samples or complex matrices. This enables a broad range of applications including fragment-based screening and kinetic analysis of small molecules, protein-protein, protein-peptide, antibody-antigen, and nucleic acid interactions.
The Creoptix WAVEsystem offers a new and unique way of measuring kinetics. Instead of relying on a titration series, waveRAPID (Repeated Analyte Pulses of Increasing Duration) injects a single concentration, pulsing the sample over the sensing surface at increasing durations. Thanks to that, kinetics can be derived from a single well speeding up screening or binding characterization measurements. Contact: Marta Janczuk-Richter e-mail: marta.janczuk@malvernpanalytical.com

Eric Ennifar, Institut de Biologie Moléculaire et Cellulaire du CNRS, Strasbourg, France Title: A multi-approach benchmarking of macromolecular interactions - Focus on kinITC

Summary: In recent years, numerous innovative biophysical methods, such as MST, BLI, and switchSENSE, have emerged for studying molecular interactions. While these technologies offer new possibilities, they also raise questions about how their results compare to established techniques like SPR and ITC microcalorimetry. Developers of these new methods often provide limited direct comparisons, leaving the scientific community to grapple with discrepancies between techniques. A recurring question arises: "Why do the results obtained using technique X differ from those generated by technique Y on the same system?". To address this, I will present results from a rigorous comparison of multiple methods, with an emphasis on the kinITC approach developed in our laboratory. This technique extends ITC's capabilities to include kinetic data alongside traditional thermodynamic measurements, offering a more comprehensive analysis of molecular interactions. Contact: Eric Ennifar e-mail: e.ennifar@unistra.fr

Please REGISTER at https://us06web.zoom.us/meeting/register/tZYuce-srDoiH9TNQotLYiRz7rk-5VJtT10N  

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FRISBI support BioStine a site to access the basics in Structural Biology https://www.biostine.fr/

Une play-list youtube dédiée à la Biologie Structurale Intégrative (Coordination: Marie-Hélène Le Du, Paris-Saclay): https://www.youtube.com/playlist?list=PLJXFANNaperht_5i-UzBTvCLAH0-CbIg6

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Last webinars:

Please follow our program of ReNaFoBis-FRISBI webinars

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FRISBI is involved and strongly support the French National training network in structural biology (ReNaFoBiS).  Aimed to be a national PhD training network, ReNaFoBiS coordinate and organize classes, workshops and training programs for students and post-docs.

See http://www.renafobis.fr/   for more information