Publications

2020 publications

An evolutionary path to altered cofactor specificity in a metalloenzyme.
Barwinska-Sendra A, Garcia YM, Sendra KM, Baslé A, Mackenzie ES, Tarrant E, Card P, Tabares LC, Bicep C, Un S, Kehl-Fie TE, Waldron KJ
Nat Commun 2020 Jun 1;11:2738

A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Wandzik JM, Kouba T, Karuppasamy M, Pflug A, Drncova P, Provaznik J, Azevedo N, Cusack S
Cell 2020 May 14;181:877-893.e21

Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation.
Bertin A, de Franceschi N, de la Mora E, Maity S, Alqabandi M, Miguet N, di Cicco A, Roos WH, Mangenot S, Weissenhorn W, Bassereau P
Nat Commun 2020 May 29;11:2663

Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.
de Las Rivas M, Paul Daniel EJ, Narimatsu Y, Compañón I, Kato K, Hermosilla P, Thureau A, Ceballos-Laita L, Coelho H, Bernadó P, Marcelo F, Hansen L, Maeda R, Lostao A, Corzana F, Clausen H, Gerken TA, Hurtado-Guerrero R
Nat Chem Biol 2020 Mar;16:351-360

Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A.
Camacho-Zarco AR, Kalayil S, Maurin D, Salvi N, Delaforge E, Milles S, Jensen MR, Hart DJ, Cusack S, Blackledge M
Nat Commun 2020 Jul 21;11:3656

Molecular dissection of amyloid disaggregation by human HSP70.
Wentink AS, Nillegoda NB, Feufel J, Ubartaitė G, Schneider CP, De Los Rios P, Hennig J, Barducci A, Bukau B
Nature 2020 Nov;587:483-488

Sensitivity-Enhanced 13 C-NMR Spectroscopy for Monitoring Multisite Phosphorylation at Physiological Temperature and pH.
Alik A, Bouguechtouli C, Julien M, Bermel W, Ghouil R, Zinn-Justin S, Theillet FX
Angew Chem Int Ed Engl 2020 Jun 22;59:10411-10415

Structural basis of transcription-translation coupling and collision in bacteria.
Webster MW, Takacs M, Zhu C, Vidmar V, Eduljee A, Abdelkareem M, Weixlbaumer A
Science 2020 Sep 11;369:1355-1359

Structure of SAGA and mechanism of TBP deposition on gene promoters.
Papai G, Frechard A, Kolesnikova O, Crucifix C, Schultz P, Ben-Shem A
Nature 2020 Jan;577:711-716

2019 publications

Assembly and cryo-EM structures of RNA-specific measles virus nucleocapsids provide mechanistic insight into paramyxoviral replication.
Desfosses A, Milles S, Jensen MR, Guseva S, Colletier JP, Maurin D, Schoehn G, Gutsche I, Ruigrok RWH, Blackledge M
Proc Natl Acad Sci U S A 2019 Mar 5;116:4256-4264

Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6.
Fuchsbauer O, Swuec P, Zimberger C, Amigues B, Levesque S, Agudelo D, Duringer A, Chaves-Sanjuan A, Spinelli S, Rousseau GM, Velimirovic M, Bolognesi M, Roussel A, Cambillau C, Moineau S, Doyon Y, Goulet A
Mol Cell 2019 Dec 19;76:922-937.e7

CENP-A nucleosome clusters form rosette-like structures around HJURP during G1.
Andronov L, Ouararhni K, Stoll I, Klaholz BP, Hamiche A
Nat Commun 2019 Sep 30;10:4436

Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex.
Vanden Broeck A, Lotz C, Ortiz J, Lamour V
Nat Commun 2019 Oct 30;10:4935

Insight into microtubule nucleation from tubulin-capping proteins.
Campanacci V, Urvoas A, Cantos-Fernandes S, Aumont-Nicaise M, Arteni AA, Velours C, Valerio-Lepiniec M, Dreier B, Plückthun A, Pilon A, Poüs C, Minard P, Gigant B
Proc Natl Acad Sci U S A 2019 May 14;116:9859-9864

Mechanistic investigation of mEos4b reveals a strategy to reduce track interruptions in sptPALM.
De Zitter E, Thédié D, Mönkemöller V, Hugelier S, Beaudouin J, Adam V, Byrdin M, Van Meervelt L, Dedecker P, Bourgeois D
Nat Methods 2019 Aug;16:707-710

MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus.
Galicia C, Lhospice S, Varela PF, Trapani S, Zhang W, Navaza J, Herrou J, Mignot T, Cherfils J
Nat Commun 2019 Nov 22;10:5300

Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01.
Pinto D, Fenwick C, Caillat C, Silacci C, Guseva S, Dehez F, Chipot C, Barbieri S, Minola A, Jarrossay D, Tomaras GD, Shen X, Riva A, Tarkowski M, Schwartz O, Bruel T, Dufloo J, Seaman MS, Montefiori DC, Lanzavecchia A, Corti D, Pantaleo G, Weissenhorn W
Cell Host Microbe 2019 Nov 13;26:623-637.e8

Structural Basis of Transcription: RNA Polymerase Backtracking and Its Reactivation.
Abdelkareem M, Saint-André C, Takacs M, Papai G, Crucifix C, Guo X, Ortiz J, Weixlbaumer A
Mol Cell 2019 Jul 25;75:298-309.e4

2018 publications

1,2-Diol Dehydration by the Radical SAM Enzyme AprD4: A Matter of Proton Circulation and Substrate Flexibility.
Liu WQ, Amara P, Mouesca JM, Ji X, Renoux O, Martin L, Zhang C, Zhang Q, Nicolet Y
J Am Chem Soc 2018 Jan 31;140:1365-1371

3DClusterViSu: 3D clustering analysis of super-resolution microscopy data by 3D Voronoi tessellations.
Andronov L, Michalon J, Ouararhni K, Orlov I, Hamiche A, Vonesch JL, Klaholz BP
Bioinformatics 2018 Sep 1;34:3004-3012

A charge polarization model for the metal-specific activity of superoxide dismutases.
Barwinska-Sendra A, Baslé A, Waldron KJ, Un S
Phys Chem Chem Phys 2018 Jan 24;20:2363-2372

Adsorption of Denaturated Lysozyme at the Air-Water Interface: Structure and Morphology.
Campbell RA, Tummino A, Varga I, Milyaeva OY, Krycki MM, Lin SY, Laux V, Haertlein M, Forsyth VT, Noskov BA
Langmuir 2018 May 1;34:5020-5029

A gated relaxation oscillator mediated by FrzX controls morphogenetic movements in Myxococcus xanthus.
Guzzo M, Murray SM, Martineau E, Lhospice S, Baronian G, My L, Zhang Y, Espinosa L, Vincentelli R, Bratton BP, Shaevitz JW, Molle V, Howard M, Mignot T
Nat Microbiol 2018 Aug;3:948-959

A General Strategy to Access Structural Information at Atomic Resolution in Polyglutamine Homorepeats.
Urbanek A, Morató A, Allemand F, Delaforge E, Fournet A, Popovic M, Delbecq S, Sibille N, Bernadó P
Angew Chem Int Ed Engl 2018 Mar 26;57:3598-3601

A Long-Lived Triplet State Is the Entrance Gateway to Oxidative Photochemistry in Green Fluorescent Proteins.
Byrdin M, Duan C, Bourgeois D, Brettel K
J Am Chem Soc 2018 Feb 28;140:2897-2905

Alpha repeat proteins (αRep) as expression and crystallization helpers.
Chevrel A, Mesneau A, Sanchez D, Celma L, Quevillon-Cheruel S, Cavagnino A, Nessler S, Li de la Sierra-Gallay I, van Tilbeurgh H, Minard P, Valerio-Lepiniec M, Urvoas A
J Struct Biol 2018 Feb;201:88-99

A mechanism for CO regulation of ion channels.
Kapetanaki SM, Burton MJ, Basran J, Uragami C, Moody PCE, Mitcheson JS, Schmid R, Davies NW, Dorlet P, Vos MH, Storey NM, Raven E
Nat Commun 2018 Mar 2;9:907

A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation.
De Muyt A, Pyatnitskaya A, Andréani J, Ranjha L, Ramus C, Laureau R, Fernandez-Vega A, Holoch D, Girard E, Govin J, Margueron R, Couté Y, Cejka P, Guérois R, Borde V
Genes Dev 2018 Feb 1;32:283-296

A Modular Receptor Platform To Expand the Sensing Repertoire of Bacteria.
Chang HJ, Mayonove P, Zavala A, De Visch A, Minard P, Cohen-Gonsaud M, Bonnet J
ACS Synth Biol 2018 Jan 19;7:166-175

A multidrug ABC transporter with a taste for GTP.
Orelle C, Durmort C, Mathieu K, Duchêne B, Aros S, Fenaille F, André F, Junot C, Vernet T, Jault JM
Sci Rep 2018 Feb 2;8:2309

An Arf6- and caveolae-dependent pathway links hemidesmosome remodeling and mechanoresponse.
Osmani N, Pontabry J, Comelles J, Fekonja N, Goetz JG, Riveline D, Georges-Labouesse E, Labouesse M
Mol Biol Cell 2018 Feb 15;29:435-451

An Automated Design Framework for Multicellular Recombinase Logic.
Guiziou S, Ulliana F, Moreau V, Leclere M, Bonnet J
ACS Synth Biol 2018 May 18;7:1406-1412

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.
Simoben CV, Robaa D, Chakrabarti A, Schmidtkunz K, Marek M, Lancelot J, Kannan S, Melesina J, Shaik TB, Pierce RJ, Romier C, Jung M, Sippl W
Molecules 2018 Mar 2;23:

An ultraweak interaction in the intrinsically disordered replication machinery is essential for measles virus function.
Milles S, Jensen MR, Lazert C, Guseva S, Ivashchenko S, Communie G, Maurin D, Gerlier D, Ruigrok RWH, Blackledge M
Sci Adv 2018 Aug;4:eaat7778

Apoprotein heterogeneity increases spectral disorder and a step-wise modification of the B850 fluorescence peak position.
Ilioaia C, Krüger TPJ, Ilioaia O, Robert B, van Grondelle R, Gall A
Biochim Biophys Acta Bioenerg 2018 Feb;1859:137-144

A putative RNA binding protein from Plasmodium vivax apicoplast.
García-Mauriño SM, Díaz-Quintana A, Rivero-Rodríguez F, Cruz-Gallardo I, Grüttner C, Hernández-Vellisca M, Díaz-Moreno I
FEBS Open Bio 2018 Feb;8:177-188

Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists.
Gogoi P, Seoane S, Sigüeiro R, Guiberteau T, Maestro MA, Pérez-Fernández R, Rochel N, Mouriño A
J Med Chem 2018 Jun 14;61:4928-4937

Assembly of an atypical α-macroglobulin complex from Pseudomonas aeruginosa.
Zouhir S, Robert-Genthon M, Trindade DM, Job V, Nedeljković M, Breyton C, Ebel C, Attrée I, Dessen A
Sci Rep 2018 Jan 11;8:527

A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts.
Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jäger D, Giesel F, Kratochwil C, Barthe P, Roumestand C, Haberkorn U
J Nucl Med 2018 Sep;59:1423-1429

Auxin sensing is a property of an unstructured domain in the Auxin Response Factor ETTIN of Arabidopsis thaliana.
Simonini S, Mas PJ, Mas CMVS, Østergaard L, Hart DJ
Sci Rep 2018 Sep 10;8:13563

Bacterial cell wall nanoimaging by autoblinking microscopy.
Floc'h K, Lacroix F, Barbieri L, Servant P, Galland R, Butler C, Sibarita JB, Bourgeois D, Timmins J
Sci Rep 2018 Sep 19;8:14038

BEST and SOFAST experiments for resonance assignment of histidine and tyrosine side chains in 13C/15N labeled proteins.
Christou NE, Brutscher B
J Biomol NMR 2018 Dec;72:115-124

Binding of pigments to the cyanobacterial high-light-inducible protein HliC.
Shukla MK, Llansola-Portoles MJ, Tichý M, Pascal AA, Robert B, Sobotka R
Photosynth Res 2018 Jul;137:29-39

C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules.
Jacquet M, Cioci G, Fouet G, Bally I, Thielens NM, Gaboriaud C, Rossi V
Front Immunol 2018 ;9:453

Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Pflug A, Gaudon S, Resa-Infante P, Lethier M, Reich S, Schulze WM, Cusack S
Nucleic Acids Res 2018 Jan 25;46:956-971

CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope.
Ventimiglia LN, Cuesta-Geijo MA, Martinelli N, Caballe A, Macheboeuf P, Miguet N, Parnham IM, Olmos Y, Carlton JG, Weissenhorn W, Martin-Serrano J
Dev Cell 2018 Dec 3;47:547-563.e6

Cell-free production, purification and characterization of human mitochondrial ADP/ATP carriers.
Woznicka-Misaila A, Juillan-Binard C, Baud D, Pebay-Peyroula E, Ravaud S
Protein Expr Purif 2018 Apr;144:46-54

Chaperonin CCT checkpoint function in basal transcription factor TFIID assembly.
Antonova SV, Haffke M, Corradini E, Mikuciunas M, Low TY, Signor L, van Es RM, Gupta K, Scheer E, Vos HR, Tora L, Heck AJR, Timmers HTM, Berger I
Nat Struct Mol Biol 2018 Dec;25:1119-1127

Characterization of a Glycyl-Specific TET Aminopeptidase Complex from Pyrococcus horikoshii.
Basbous H, Appolaire A, Girard E, Franzetti B
J Bacteriol 2018 Sep 1;200:

Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
Marek M, Shaik TB, Heimburg T, Chakrabarti A, Lancelot J, Ramos-Morales E, Da Veiga C, Kalinin D, Melesina J, Robaa D, Schmidtkunz K, Suzuki T, Holl R, Ennifar E, Pierce RJ, Jung M, Sippl W, Romier C
J Med Chem 2018 Nov 21;61:10000-10016

Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the Potential for Broad Anti-Flaviviridae Activity.
Nevers Q, Ruiz I, Ahnou N, Donati F, Brillet R, Softic L, Chazal M, Jouvenet N, Fourati S, Baudesson C, Bruscella P, Gelin M, Guichou JF, Pawlotsky JM, Ahmed-Belkacem A
Antimicrob Agents Chemother 2018 Jul;62:

Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1).
Nguyen TQ, Aumont-Nicaise M, Andreani J, Velours C, Chenon M, Vilela F, Geneste C, Varela PF, Llinas P, Ménétrey J
J Biol Chem 2018 Sep 7;293:13946-13960

Chemoenzymatic Synthesis of N-glycan Positional Isomers and Evidence for Branch Selective Binding by Monoclonal Antibodies and Human C-type Lectin Receptors.
Echeverria B, Serna S, Achilli S, Vivès C, Pham J, Thépaut M, Hokke CH, Fieschi F, Reichardt NC
ACS Chem Biol 2018 Aug 17;13:2269-2279

Conformational sampling of the intrinsically disordered dsRBD-1 domain from Arabidopsis thaliana DCL1.
Suárez IP, Gauto DF, Hails G, Mascali FC, Crespo R, Zhao L, Wang J, Rasia RM
Phys Chem Chem Phys 2018 Apr 25;20:11237-11246

Conformational transitions of the serotonin 5-HT3 receptor.
Polovinkin L, Hassaine G, Perot J, Neumann E, Jensen AA, Lefebvre SN, Corringer PJ, Neyton J, Chipot C, Dehez F, Schoehn G, Nury H
Nature 2018 Nov;563:275-279

Cryo-EM structure of the hibernating Thermus thermophilus 100S ribosome reveals a protein-mediated dimerization mechanism.
Flygaard RK, Boegholm N, Yusupov M, Jenner LB
Nat Commun 2018 Oct 9;9:4179

Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru-papain conjugate.
Cherrier MV, Amara P, Talbi B, Salmain M, Fontecilla-Camps JC
Metallomics 2018 Oct 17;10:1452-1459

Crystallographic Trapping of Reaction Intermediates in Quinolinic Acid Synthesis by NadA.
Volbeda A, Saez Cabodevilla J, Darnault C, Gigarel O, Han TH, Renoux O, Hamelin O, Ollagnier-de-Choudens S, Amara P, Fontecilla-Camps JC
ACS Chem Biol 2018 May 18;13:1209-1217

Crystal structure of phosphomannose isomerase from Candida albicans complexed with 5-phospho-d-arabinonhydrazide.
Ahmad L, Plancqueel S, Dubosclard V, Lazar N, Ghattas W, Li de la Sierra-Gallay I, van Tilbeurgh H, Salmon L
FEBS Lett 2018 May;592:1667-1680

Deciphering the Dynamic Interaction Profile of an Intrinsically Disordered Protein by NMR Exchange Spectroscopy.
Delaforge E, Kragelj J, Tengo L, Palencia A, Milles S, Bouvignies G, Salvi N, Blackledge M, Jensen MR
J Am Chem Soc 2018 Jan 24;140:1148-1158

Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase.
Crespo I, Giménez-Dejoz J, Porté S, Cousido-Siah A, Mitschler A, Podjarny A, Pratsinis H, Kletsas D, Parés X, Ruiz FX, Metwally K, Farrés J
Eur J Med Chem 2018 May 25;152:160-174

Differential regulation of actin-activated nucleotidyl cyclase virulence factors by filamentous and globular actin.
Raoux-Barbot D, Belyy A, Worpenberg L, Montluc S, Deville C, Henriot V, Velours C, Ladant D, Renault L, Mechold U
PLoS One 2018 ;13:e0206133

Disentangling the molecular determinants for Cenp-F localization to nuclear pores and kinetochores.
Berto A, Yu J, Morchoisne-Bolhy S, Bertipaglia C, Vallee R, Dumont J, Ochsenbein F, Guerois R, Doye V
EMBO Rep 2018 May;19:

DNA-Functionalized Dye-Loaded Polymeric Nanoparticles: Ultrabright FRET Platform for Amplified Detection of Nucleic Acids.
Melnychuk N, Klymchenko AS
J Am Chem Soc 2018 Aug 29;140:10856-10865

Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide.
Mizuta R, Devos JM, Webster J, Ling WL, Narayanan T, Round A, Munnur D, Mossou E, Farahat AA, Boykin DW, Wilson WD, Neidle S, Schweins R, Rannou P, Haertlein M, Forsyth VT, Mitchell EP
Nanoscale 2018 Mar 28;10:5550-5558

FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination.
Fernandes JB, Duhamel M, Seguéla-Arnaud M, Froger N, Girard C, Choinard S, Solier V, De Winne N, De Jaeger G, Gevaert K, Andrey P, Grelon M, Guerois R, Kumar R, Mercier R
PLoS Genet 2018 Apr;14:e1007317

Fine Mapping the Interaction Between Dendritic Cell-Specific Intercellular Adhesion Molecule (ICAM)-3-Grabbing Nonintegrin and the Cytomegalovirus Envelope Glycoprotein B.
Chéneau C, Coulon F, Porkolab V, Fieschi F, Laurant S, Razanajaona-Doll D, Pin JJ, Borst EM, Messerle M, Bressollette-Bodin C, Halary F
J Infect Dis 2018 Jul 2;218:490-503

First demonstration of the circulation of a pneumovirus in French pigs by detection of anti-swine orthopneumovirus nucleoprotein antibodies.
Richard CA, Hervet C, Ménard D, Gutsche I, Normand V, Renois F, Meurens F, Eléouët JF
Vet Res 2018 Dec 5;49:118

Fluorinated diglucose detergents for membrane-protein extraction.
Boussambe GNM, Guillet P, Mahler F, Marconnet A, Vargas C, Cornut D, Soulié M, Ebel C, Le Roy A, Jawhari A, Bonneté F, Keller S, Durand G
Methods 2018 Sep 1;147:84-94

From deep TLS validation to ensembles of atomic models built from elemental motions. II. Analysis of TLS refinement results by explicit interpretation.
Afonine PV, Adams PD, Urzhumtsev A
Acta Crystallogr D Struct Biol 2018 Jul 1;74:621-631

Functional carbohydrate binding modules identified in evolved dits from siphophages infecting various Gram-positive bacteria.
Hayes S, Vincentelli R, Mahony J, Nauta A, Ramond L, Lugli GA, Ventura M, van Sinderen D, Cambillau C
Mol Microbiol 2018 Dec;110:777-795

Functional characterization of cell-free expressed Kv1.3 channel using a voltage-sensitive fluorescent dye.
Cortes S, Barette C, Beroud R, De Waard M, Schaack B
Protein Expr Purif 2018 May;145:94-99

Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics.
Melková K, Zapletal V, Jansen S, Nomilner E, Zachrdla M, Hritz J, Nováček J, Zweckstetter M, Jensen MR, Blackledge M, Žídek L
J Biol Chem 2018 Aug 24;293:13297-13309

Genetic and enzymatic characterization of 3-O-sulfotransferase SNPs associated with Plasmodium falciparum parasitaemia.
Nguyen NT, Vivès RR, Torres M, Delauzun V, Saesen E, Roig-Zamboni V, Lortat-Jacob H, Rihet P, Bourne Y
Glycobiology 2018 Jul 1;28:534-541

Glycolate Induces Redox Tuning Of Photosystem II in Vivo: Study of a Photorespiration Mutant.
Messant M, Timm S, Fantuzzi A, Weckwerth W, Bauwe H, Rutherford AW, Krieger-Liszkay A
Plant Physiol 2018 Jul;177:1277-1285

Glycosylate and move! The glycosyltransferase Maf is involved in bacterial flagella formation.
Sulzenbacher G, Roig-Zamboni V, Lebrun R, Guérardel Y, Murat D, Mansuelle P, Yamakawa N, Qian XX, Vincentelli R, Bourne Y, Wu LF, Alberto F
Environ Microbiol 2018 Jan;20:228-240

High concentrations of GTP induce conformational changes in the essential bacterial GTPase EngA and enhance its binding to the ribosome.
da Silveira Tomé C, Foucher AE, Jault JM, Housset D
FEBS J 2018 Jan;285:160-177

Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors.
Halby L, Marechal N, Pechalrieu D, Cura V, Franchini DM, Faux C, Alby F, Troffer-Charlier N, Kudithipudi S, Jeltsch A, Aouadi W, Decroly E, Guillemot JC, Page P, Ferroud C, Bonnefond L, Guianvarc'h D, Cavarelli J, Arimondo PB
Philos Trans R Soc Lond B Biol Sci 2018 Jun 5;373:

How Detergent Impacts Membrane Proteins: Atomic-Level Views of Mitochondrial Carriers in Dodecylphosphocholine.
Kurauskas V, Hessel A, Ma P, Lunetti P, Weinhäupl K, Imbert L, Brutscher B, King MS, Sounier R, Dolce V, Kunji ERS, Capobianco L, Chipot C, Dehez F, Bersch B, Schanda P
J Phys Chem Lett 2018 Mar 1;9:933-938

Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis.
Mikulecky P, Andreeva E, Amara P, Weissenhorn W, Nicolet Y, Macheboeuf P
FEBS Lett 2018 Jan;592:199-208

Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites.
Di Mattia T, Wilhelm LP, Ikhlef S, Wendling C, Spehner D, Nominé Y, Giordano F, Mathelin C, Drin G, Tomasetto C, Alpy F
EMBO Rep 2018 Jul;19:

Impact of a Model Soil Microorganism and of Its Secretome on the Fate of Silver Nanoparticles.
Eymard-Vernain E, Lelong C, Pradas Del Real AE, Soulas R, Bureau S, Tardillo Suarez V, Gallet B, Proux O, Castillo-Michel H, Sarret G
Environ Sci Technol 2018 Jan 2;52:71-78

Impact of the surface charge of polydiacetylene micelles on their interaction with human innate immune protein C1q and the complement system.
Thielens NM, Belime A, Gravel E, Ancelet S, Caneiro C, Doris E, Ling WL
Int J Pharm 2018 Jan 30;536:434-439

Importance of Post-translational Modifications in the Interaction of Proteins with Mineral Surfaces: The Case of Arginine Methylation and Silica surfaces.
Marichal L, Renault JP, Chédin S, Lagniel G, Klein G, Aude JC, Tellier-Lebegue C, Armengaud J, Pin S, Labarre J, Boulard Y
Langmuir 2018 May 8;34:5312-5322

Induced conformational changes activate the peptidoglycan synthase PBP1B.
Egan AJF, Maya-Martinez R, Ayala I, Bougault CM, Banzhaf M, Breukink E, Vollmer W, Simorre JP
Mol Microbiol 2018 Nov;110:335-356

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach.
Hoffer L, Voitovich YV, Raux B, Carrasco K, Muller C, Fedorov AY, Derviaux C, Amouric A, Betzi S, Horvath D, Varnek A, Collette Y, Combes S, Roche P, Morelli X
J Med Chem 2018 Jul 12;61:5719-5732

InterEvDock2: an expanded server for protein docking using evolutionary and biological information from homology models and multimeric inputs.
Quignot C, Rey J, Yu J, Tufféry P, Guerois R, Andreani J
Nucleic Acids Res 2018 Jul 2;46:W408-W416

Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities.
Lin Z, Marepally SR, Goh ESY, Cheng CYS, Janjetovic Z, Kim TK, Miller DD, Postlethwaite AE, Slominski AT, Tuckey RC, Peluso-Iltis C, Rochel N, Li W
Sci Rep 2018 Jan 24;8:1478

Kinetic analysis methods applied to single motor protein trajectories.
Nord AL, Pols AF, Depken M, Pedaci F
Phys Chem Chem Phys 2018 Jul 11;20:18775-18781

1H, 13C and 15N backbone resonance assignment of the lamin C-terminal region specific to prelamin A.
Celli F, Petitalot A, Samson C, Theillet FX, Zinn-Justin S
Biomol NMR Assign 2018 Oct;12:225-229

Lycopene crystalloids exhibit singlet exciton fission in tomatoes.
Llansola-Portoles MJ, Redeckas K, Streckaité S, Ilioaia C, Pascal AA, Telfer A, Vengris M, Valkunas L, Robert B
Phys Chem Chem Phys 2018 Mar 28;20:8640-8646

Lytic xylan oxidases from wood-decay fungi unlock biomass degradation.
Couturier M, Ladevèze S, Sulzenbacher G, Ciano L, Fanuel M, Moreau C, Villares A, Cathala B, Chaspoul F, Frandsen KE, Labourel A, Herpoël-Gimbert I, Grisel S, Haon M, Lenfant N, Rogniaux H, Ropartz D, Davies GJ, Rosso MN, Walton PH, Henrissat B, Berrin JG
Nat Chem Biol 2018 Mar;14:306-310

Mapping of Adenovirus of serotype 3 fibre interaction to desmoglein 2 revealed a novel 'non-classical' mechanism of viral receptor engagement.
Vassal-Stermann E, Mottet M, Ducournau C, Iseni F, Vragniau C, Wang H, Zubieta C, Lieber A, Fender P
Sci Rep 2018 May 30;8:8381

Membrane Solubilization by Styrene-Maleic Acid Copolymers: Delineating the Role of Polymer Length.
Domínguez Pardo JJ, Koorengevel MC, Uwugiaren N, Weijers J, Kopf AH, Jahn H, van Walree CA, van Steenbergen MJ, Killian JA
Biophys J 2018 Jul 3;115:129-138

microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site.
Schult P, Roth H, Adams RL, Mas C, Imbert L, Orlik C, Ruggieri A, Pyle AM, Lohmann V
Nat Commun 2018 Jul 4;9:2613

Mode of PEG Coverage on Carbon Nanotubes Affects Binding of Innate Immune Protein C1q.
Belime A, Gravel E, Brenet S, Ancelet S, Caneiro C, Hou Y, Thielens N, Doris E, Ling WL
J Phys Chem B 2018 Jan 18;122:757-763

Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase.
Van Laer B, Kapp U, Soler-Lopez M, Moczulska K, Pääbo S, Leonard G, Mueller-Dieckmann C
Sci Rep 2018 Dec 20;8:18008

Molecular structure of promoter-bound yeast TFIID.
Kolesnikova O, Ben-Shem A, Luo J, Ranish J, Schultz P, Papai G
Nat Commun 2018 Nov 7;9:4666

Monitoring Unfolding of Titin I27 Single and Bi Domain with High-Pressure NMR Spectroscopy.
Herrada I, Barthe P, Vanheusden M, DeGuillen K, Mammri L, Delbecq S, Rico F, Roumestand C
Biophys J 2018 Jul 17;115:341-352

Nanovirus DNA-N encodes a protein mandatory for aphid transmission.
Grigoras I, Vetten HJ, Commandeur U, Ziebell H, Gronenborn B, Timchenko T
Virology 2018 Sep;522:281-291

New branched amino acids for high affinity dendrimeric DC-SIGN ligands.
Cattiaux L, Porkolab V, Fieschi F, Mallet JM
Bioorg Med Chem 2018 Mar 1;26:1006-1015

New tools for the analysis and validation of cryo-EM maps and atomic models.
Afonine PV, Klaholz BP, Moriarty NW, Poon BK, Sobolev OV, Terwilliger TC, Adams PD, Urzhumtsev A
Acta Crystallogr D Struct Biol 2018 Sep 1;74:814-840

NR3E receptors in cnidarians: A new family of steroid receptor relatives extends the possible mechanisms for ligand binding.
Khalturin K, Billas IML, Chebaro Y, Reitzel AM, Tarrant AM, Laudet V, Markov GV
J Steroid Biochem Mol Biol 2018 Nov;184:11-19

Nucleoprotein from the unique human infecting Orthobunyavirus of Simbu serogroup (Oropouche virus) forms higher order oligomers in complex with nucleic acids in vitro.
Murillo JL, Cabral AD, Uehara M, da Silva VM, Dos Santos JV, Muniz JRC, Estrozi LF, Fenel D, Garcia W, Sperança MA
Amino Acids 2018 Jun;50:711-721

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin.
Medve L, Achilli S, Serna S, Zuccotto F, Varga N, Thépaut M, Civera M, Vivès C, Fieschi F, Reichardt N, Bernardi A
Chemistry 2018 Sep 25;24:14448-14460

One-Pot Two-Step Metabolic Labeling of Teichoic Acids and Direct Labeling of Peptidoglycan Reveals Tight Coordination of Both Polymers Inserted into Pneumococcus Cell Wall.
Bonnet J, Wong YS, Vernet T, Di Guilmi AM, Zapun A, Durmort C
ACS Chem Biol 2018 Aug 17;13:2010-2015

One-step affinity purification of fusion proteins with optimal monodispersity and biological activity: application to aggregation-prone HPV E6 proteins.
Bonhoure A, Demenge A, Kostmann C, San José L, De la Cal E, Armisen P, Nominé Y, Travé G
Microb Cell Fact 2018 Dec 1;17:191

Pathological Interactions Between Mutant Thyroid Hormone Receptors and Corepressors and Their Modulation by a Thyroid Hormone Analogue with Therapeutic Potential.
Harrus D, Déméné H, Vasquez E, Boulahtouf A, Germain P, Figueira AC, Privalsky ML, Bourguet W, le Maire A
Thyroid 2018 Dec;28:1708-1722

Perdeuteration of cholesterol for neutron scattering applications using recombinant Pichia pastoris.
Moulin M, Strohmeier GA, Hirz M, Thompson KC, Rennie AR, Campbell RA, Pichler H, Maric S, Forsyth VT, Haertlein M
Chem Phys Lipids 2018 May;212:80-87

Photochemistry beyond the red limit in chlorophyll f-containing photosystems.
Nürnberg DJ, Morton J, Santabarbara S, Telfer A, Joliot P, Antonaru LA, Ruban AV, Cardona T, Krausz E, Boussac A, Fantuzzi A, Rutherford AW
Science 2018 Jun 15;360:1210-1213

Pigment configuration in the light-harvesting protein of the xanthophyte alga Xanthonema debile.
Streckaite S, Gardian Z, Li F, Pascal AA, Litvin R, Robert B, Llansola-Portoles MJ
Photosynth Res 2018 Nov;138:139-148

Porin self-association enables cell-to-cell contact in Providencia stuartii floating communities.
El-Khatib M, Nasrallah C, Lopes J, Tran QT, Tetreau G, Basbous H, Fenel D, Gallet B, Lethier M, Bolla JM, Pagès JM, Vivaudou M, Weik M, Winterhalter M, Colletier JP
Proc Natl Acad Sci U S A 2018 Mar 6;115:E2220-E2228

Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain.
Bedez C, Lotz C, Batisse C, Broeck AV, Stote RH, Howard E, Pradeau-Aubreton K, Ruff M, Lamour V
Sci Rep 2018 Jun 18;8:9272

Probing the role of Valine 185 of the D1 protein in the Photosystem II oxygen evolution.
Sugiura M, Tibiletti T, Takachi I, Hara Y, Kanawaku S, Sellés J, Boussac A
Biochim Biophys Acta Bioenerg 2018 Dec;1859:1259-1273

Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells.
Tacnet-Delorme P, Gabillet J, Chatfield S, Thieblemont N, Frachet P, Witko-Sarsat V
Front Immunol 2018 ;9:818

Protein Flexibility and Synergy of HMG Domains Underlie U-Turn Bending of DNA by TFAM in Solution.
Rubio-Cosials A, Battistini F, Gansen A, Cuppari A, Bernadó P, Orozco M, Langowski J, Tóth K, Solà M
Biophys J 2018 May 22;114:2386-2396

Radical S-Adenosyl-l-methionine Tryptophan Lyase (NosL): How the Protein Controls the Carboxyl Radical •CO2- Migration.
Amara P, Mouesca JM, Bella M, Martin L, Saragaglia C, Gambarelli S, Nicolet Y
J Am Chem Soc 2018 Dec 5;140:16661-16668

Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition.
Porkolab V, Chabrol E, Varga N, Ordanini S, Sutkevičiu Tė I, Thépaut M, García-Jiménez MJ, Girard E, Nieto PM, Bernardi A, Fieschi F
ACS Chem Biol 2018 Mar 16;13:600-608

Real-space refinement in PHENIX for cryo-EM and crystallography.
Afonine PV, Poon BK, Read RJ, Sobolev OV, Terwilliger TC, Urzhumtsev A, Adams PD
Acta Crystallogr D Struct Biol 2018 Jun 1;74:531-544

Regulation of Hydroxycinnamic Acid Degradation Drives Agrobacterium fabrum Lifestyles.
Meyer T, Renoud S, Vigouroux A, Miomandre A, Gaillard V, Kerzaon I, Prigent-Combaret C, Comte G, Moréra S, Vial L, Lavire C
Mol Plant Microbe Interact 2018 Aug;31:814-822

RIP2 filament formation is required for NOD2 dependent NF-κB signalling.
Pellegrini E, Desfosses A, Wallmann A, Schulze WM, Rehbein K, Mas P, Signor L, Gaudon S, Zenkeviciute G, Hons M, Malet H, Gutsche I, Sachse C, Schoehn G, Oschkinat H, Cusack S
Nat Commun 2018 Oct 2;9:4043

Robo1 Forms a Compact Dimer-of-Dimers Assembly.
Aleksandrova N, Gutsche I, Kandiah E, Avilov SV, Petoukhov MV, Seiradake E, McCarthy AA
Structure 2018 Feb 6;26:320-328.e4

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.
Martino F, Pal M, Muñoz-Hernández H, Rodríguez CF, Núñez-Ramírez R, Gil-Carton D, Degliesposti G, Skehel JM, Roe SM, Prodromou C, Pearl LH, Llorca O
Nat Commun 2018 Apr 16;9:1501

Second-Shell Basic Residues Expand the Two-Metal-Ion Architecture of DNA and RNA Processing Enzymes.
Genna V, Colombo M, De Vivo M, Marcia M
Structure 2018 Jan 2;26:40-50.e2

Sequence-dependent catalytic regulation of the SpoIIIE motor activity ensures directionality of DNA translocation.
Chara O, Borges A, Milhiet PE, Nöllmann M, Cattoni DI
Sci Rep 2018 Mar 27;8:5254

Solid State NMR Studies of Intact Lipopolysaccharide Endotoxin.
Laguri C, Silipo A, Martorana AM, Schanda P, Marchetti R, Polissi A, Molinaro A, Simorre JP
ACS Chem Biol 2018 Aug 17;13:2106-2113

Specific recognition of two MAX effectors by integrated HMA domains in plant immune receptors involves distinct binding surfaces.
Guo L, Cesari S, de Guillen K, Chalvon V, Mammri L, Ma M, Meusnier I, Bonnot F, Padilla A, Peng YL, Liu J, Kroj T
Proc Natl Acad Sci U S A 2018 Nov 6;115:11637-11642

Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting.
Schulze WM, Stein F, Rettel M, Nanao M, Cusack S
Nat Commun 2018 Apr 27;9:1701

Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases.
Samson C, Petitalot A, Celli F, Herrada I, Ropars V, Le Du MH, Nhiri N, Jacquet E, Arteni AA, Buendia B, Zinn-Justin S
Nucleic Acids Res 2018 Nov 2;46:10460-10473

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA.
Ferron F, Subissi L, Silveira De Morais AT, Le NTT, Sevajol M, Gluais L, Decroly E, Vonrhein C, Bricogne G, Canard B, Imbert I
Proc Natl Acad Sci U S A 2018 Jan 9;115:E162-E171

Structural Basis for NusA Stabilized Transcriptional Pausing.
Guo X, Myasnikov AG, Chen J, Crucifix C, Papai G, Takacs M, Schultz P, Weixlbaumer A
Mol Cell 2018 Mar 1;69:816-827.e4

Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein.
Nikolic J, Belot L, Raux H, Legrand P, Gaudin Y, A Albertini A
Nat Commun 2018 Mar 12;9:1029

Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space.
Weinhäupl K, Lindau C, Hessel A, Wang Y, Schütze C, Jores T, Melchionda L, Schönfisch B, Kalbacher H, Bersch B, Rapaport D, Brennich M, Lindorff-Larsen K, Wiedemann N, Schanda P
Cell 2018 Nov 15;175:1365-1379.e25

Structural Basis of Outstanding Multivalent Effects in Jack Bean α-Mannosidase Inhibition.
Howard E, Cousido-Siah A, Lepage ML, Schneider JP, Bodlenner A, Mitschler A, Meli A, Izzo I, Alvarez HA, Podjarny A, Compain P
Angew Chem Int Ed Engl 2018 Jul 2;57:8002-8006

Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis.
Guca E, Nagy GN, Hajdú F, Marton L, Izrael R, Hoh F, Yang Y, Vial H, Vértessy BG, Guichou JF, Cerdan R
Sci Rep 2018 Jul 25;8:11215

Structural features of the salivary gland hypertrophy virus of the tsetse fly revealed by cryo-electron microscopy and tomography.
Orlov I, Drillien R, Spehner D, Bergoin M, Abd-Alla AMM, Klaholz BP
Virology 2018 Jan 15;514:165-169

Structural Insights in Multifunctional Papillomavirus Oncoproteins.
Suarez I, Trave G
Viruses 2018 Jan 15;10:

Structural investigation of a chaperonin in action reveals how nucleotide binding regulates the functional cycle.
Mas G, Guan JY, Crublet E, Debled EC, Moriscot C, Gans P, Schoehn G, Macek P, Schanda P, Boisbouvier J
Sci Adv 2018 Sep;4:eaau4196

Structure and dynamics of Helicobacter pylori nickel-chaperone HypA: an integrated approach using NMR spectroscopy, functional assays and computational tools.
Spronk CAEM, Żerko S, Górka M, Koźmiński W, Bardiaux B, Zambelli B, Musiani F, Piccioli M, Basak P, Blum FC, Johnson RC, Hu H, Merrell DS, Maroney M, Ciurli S
J Biol Inorg Chem 2018 Dec;23:1309-1330

Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
Bonnard D, Le Rouzic E, Eiler S, Amadori C, Orlov I, Bruneau JM, Brias J, Barbion J, Chevreuil F, Spehner D, Chasset S, Ledoussal B, Moreau F, Saïb A, Klaholz BP, Emiliani S, Ruff M, Zamborlini A, Benarous R
J Biol Chem 2018 Apr 20;293:6172-6186

Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification.
Pichard-Kostuch A, Zhang W, Liger D, Daugeron MC, Létoquart J, Li de la Sierra-Gallay I, Forterre P, Collinet B, van Tilbeurgh H, Basta T
RNA 2018 Jul;24:926-938

Structure of an H1-Bound 6-Nucleosome Array Reveals an Untwisted Two-Start Chromatin Fiber Conformation.
Garcia-Saez I, Menoni H, Boopathi R, Shukla MS, Soueidan L, Noirclerc-Savoye M, Le Roy A, Skoufias DA, Bednar J, Hamiche A, Angelov D, Petosa C, Dimitrov S
Mol Cell 2018 Dec 6;72:902-915.e7

Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae.
Morlot C, Straume D, Peters K, Hegnar OA, Simon N, Villard AM, Contreras-Martel C, Leisico F, Breukink E, Gravier-Pelletier C, Le Corre L, Vollmer W, Pietrancosta N, Håvarstein LS, Zapun A
Nat Commun 2018 Aug 9;9:3180

Sub-nanosecond tryptophan radical deprotonation mediated by a protein-bound water cluster in class II DNA photolyases.
Müller P, Ignatz E, Kiontke S, Brettel K, Essen LO
Chem Sci 2018 Feb 7;9:1200-1212

Switching an Individual Phycobilisome Off and On.
Gwizdala M, Botha JL, Wilson A, Kirilovsky D, van Grondelle R, Krüger TPJ
J Phys Chem Lett 2018 May 3;9:2426-2432

Synthesis of Avibactam Derivatives and Activity on β-Lactamases and Peptidoglycan Biosynthesis Enzymes of Mycobacteria.
Edoo Z, Iannazzo L, Compain F, Li de la Sierra Gallay I, van Tilbeurgh H, Fonvielle M, Bouchet F, Le Run E, Mainardi JL, Arthur M, Ethève-Quelquejeu M, Hugonnet JE
Chemistry 2018 Jun 7;24:8081-8086

Tau can switch microtubule network organizations: from random networks to dynamic and stable bundles.
Prezel E, Elie A, Delaroche J, Stoppin-Mellet V, Bosc C, Serre L, Fourest-Lieuvin A, Andrieux A, Vantard M, Arnal I
Mol Biol Cell 2018 Jan 15;29:154-165

The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation.
Handberg-Thorsager M, Gutierrez-Mazariegos J, Arold ST, Kumar Nadendla E, Bertucci PY, Germain P, Tomançak P, Pierzchalski K, Jones JW, Albalat R, Kane MA, Bourguet W, Laudet V, Arendt D, Schubert M
Sci Adv 2018 Feb;4:eaao1261

The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis.
Weinhäupl K, Brennich M, Kazmaier U, Lelievre J, Ballell L, Goldberg A, Schanda P, Fraga H
J Biol Chem 2018 Jun 1;293:8379-8393

The cell wall hydrolase Pmp23 is important for assembly and stability of the division ring in Streptococcus pneumoniae.
Jacq M, Arthaud C, Manuse S, Mercy C, Bellard L, Peters K, Gallet B, Galindo J, Doan T, Vollmer W, Brun YV, VanNieuwenhze MS, Di Guilmi AM, Vernet T, Grangeasse C, Morlot C
Sci Rep 2018 May 15;8:7591

The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1.
Sosnowski P, Urnavicius L, Boland A, Fagiewicz R, Busselez J, Papai G, Schmidt H
Elife 2018 Nov 26;7:

The low spin - high spin equilibrium in the S2-state of the water oxidizing enzyme.
Boussac A, Ugur I, Marion A, Sugiura M, Kaila VRI, Rutherford AW
Biochim Biophys Acta Bioenerg 2018 May;1859:342-356

The plant defense signal galactinol is specifically used as a nutrient by the bacterial pathogen Agrobacterium fabrum.
Meyer T, Vigouroux A, Aumont-Nicaise M, Comte G, Vial L, Lavire C, Moréra S
J Biol Chem 2018 May 25;293:7930-7941

The plastid-nucleus located DNA/RNA binding protein WHIRLY1 regulates microRNA-levels during stress in barley (Hordeum vulgare L.).
Świda-Barteczka A, Krieger-Liszkay A, Bilger W, Voigt U, Hensel G, Szweykowska-Kulinska Z, Krupinska K
RNA Biol 2018 ;15:886-891

The structure of an elongation factor G-ribosome complex captured in the absence of inhibitors.
Macé K, Giudice E, Chat S, Gillet R
Nucleic Acids Res 2018 Apr 6;46:3211-3217

The structure of the TsaB/TsaD/TsaE complex reveals an unexpected mechanism for the bacterial t6A tRNA-modification.
Missoury S, Plancqueel S, Li de la Sierra-Gallay I, Zhang W, Liger D, Durand D, Dammak R, Collinet B, van Tilbeurgh H
Nucleic Acids Res 2018 Jun 20;46:5850-5860

Towards a complete structural deciphering of Type VI secretion system.
Nguyen VS, Douzi B, Durand E, Roussel A, Cascales E, Cambillau C
Curr Opin Struct Biol 2018 Apr;49:77-84

Toward the Discovery of a Novel Class of YAP⁻TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP⁻TEAD Protein⁻Protein Interface.
Gibault F, Coevoet M, Sturbaut M, Farce A, Renault N, Allemand F, Guichou JF, Drucbert AS, Foulon C, Magnez R, Thuru X, Corvaisier M, Huet G, Chavatte P, Melnyk P, Bailly F, Cotelle P
Cancers (Basel) 2018 May 8;10:

Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis.
Turapov O, Forti F, Kadhim B, Ghisotti D, Sassine J, Straatman-Iwanowska A, Bottrill AR, Moynihan PJ, Wallis R, Barthe P, Cohen-Gonsaud M, Ajuh P, Vollmer W, Mukamolova GV
Cell Rep 2018 Oct 2;25:57-67.e5

Type IX secretion system PorM and gliding machinery GldM form arches spanning the periplasmic space.
Leone P, Roche J, Vincent MS, Tran QH, Desmyter A, Cascales E, Kellenberger C, Cambillau C, Roussel A
Nat Commun 2018 Jan 30;9:429

Unveiling the Binding Modes of the Crystallophore, a Terbium-based Nucleating and Phasing Molecular Agent for Protein Crystallography.
Engilberge S, Riobé F, Wagner T, Di Pietro S, Breyton C, Franzetti B, Shima S, Girard E, Dumont E, Maury O
Chemistry 2018 Jul 11;24:9739-9746

Virtual Screening Against Carbohydrate-Binding Proteins: Evaluation and Application to Bacterial Burkholderia ambifaria Lectin.
Dingjan T, Gillon É, Imberty A, Pérez S, Titz A, Ramsland PA, Yuriev E
J Chem Inf Model 2018 Sep 24;58:1976-1989

Volta phase plate data collection facilitates image processing and cryo-EM structure determination.
von Loeffelholz O, Papai G, Danev R, Myasnikov AG, Natchiar SK, Hazemann I, Ménétret JF, Klaholz BP
J Struct Biol 2018 Jun;202:191-199

Water Molecules Gating a Photoinduced One-Electron Two-Protons Transfer in a Tyrosine/Histidine (Tyr/His) Model of Photosystem II.
Chararalambidis G, Das S, Trapali A, Quaranta A, Orio M, Halime Z, Fertey P, Guillot R, Coutsolelos A, Leibl W, Aukauloo A, Sircoglou M
Angew Chem Int Ed Engl 2018 Jul 16;57:9013-9017

XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nemoz C, Ropars V, Frit P, Gontier A, Drevet P, Yu J, Guerois R, Pitois A, Comte A, Delteil C, Barboule N, Legrand P, Baconnais S, Yin Y, Tadi S, Barbet-Massin E, Berger I, Le Cam E, Modesti M, Rothenberg E, Calsou P, Charbonnier JB
Nat Struct Mol Biol 2018 Oct;25:971-980

X-ray structural, functional and computational studies of the O2-sensitive E. coli hydrogenase-1 C19G variant reveal an unusual [4Fe-4S] cluster.
Volbeda A, Mouesca JM, Darnault C, Roessler MM, Parkin A, Armstrong FA, Fontecilla-Camps JC
Chem Commun (Camb) 2018 Jun 26;54:7175-7178

X-ray structure of full-length human RuvB-Like 2 - mechanistic insights into coupling between ATP binding and mechanical action.
Silva STN, Brito JA, Arranz R, Sorzano CÓS, Ebel C, Doutch J, Tully MD, Carazo JM, Carrascosa JL, Matias PM, Bandeiras TM
Sci Rep 2018 Sep 13;8:13726

2017 publications

A jasmonic acid derivative improves skin healing and induces changes in proteoglycan expression and glycosaminoglycan structure.
Henriet E, Jäger S, Tran C, Bastien P, Michelet JF, Minondo AM, Formanek F, Dalko-Csiba M, Lortat-Jacob H, Breton L, Vivès RR
Biochim Biophys Acta Gen Subj 2017 Sep;1861:2250-2260

Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptorγ.
Chebaro Y, Sirigu S, Amal I, Lutzing R, Stote RH, Rochette-Egly C, Rochel N, Dejaegere A
PLoS One 2017 ;12:e0171043

Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Prokhorova I, Altman RB, Djumagulov M, Shrestha JP, Urzhumtsev A, Ferguson A, Chang CT, Yusupov M, Blanchard SC, Yusupova G
Proc Natl Acad Sci U S A 2017 Dec 19;114:E10899-E10908

A mobile loop near the active site acts as a switch between the dual activities of a viral protease/deubiquitinase.
Jupin I, Ayach M, Jomat L, Fieulaine S, Bressanelli S
PLoS Pathog 2017 Nov;13:e1006714

An algal photoenzyme converts fatty acids to hydrocarbons.
Sorigué D, Légeret B, Cuiné S, Blangy S, Moulin S, Billon E, Richaud P, Brugière S, Couté Y, Nurizzo D, Müller P, Brettel K, Pignol D, Arnoux P, Li-Beisson Y, Peltier G, Beisson F
Science 2017 Sep 1;357:903-907

Analytical Description of NMR Relaxation Highlights Correlated Dynamics in Intrinsically Disordered Proteins.
Salvi N, Abyzov A, Blackledge M
Angew Chem Int Ed Engl 2017 Nov 6;56:14020-14024

Antigp41 membrane proximal external region antibodies and the art of using the membrane for neutralization.
Cerutti N, Loredo-Varela JL, Caillat C, Weissenhorn W
Curr Opin HIV AIDS 2017 May;12:250-256

A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations.
Yerabham ASK, Mas PJ, Decker C, Soares DC, Weiergräber OH, Nagel-Steger L, Willbold D, Hart DJ, Bradshaw NJ, Korth C
J Biol Chem 2017 Apr 21;292:6468-6477

Atomic resolution conformational dynamics of intrinsically disordered proteins from NMR spin relaxation.
Salvi N, Abyzov A, Blackledge M
Prog Nucl Magn Reson Spectrosc 2017 Nov;102-103:43-60

A Two-component NADPH Oxidase (NOX)-like System in Bacteria Is Involved in the Electron Transfer Chain to the Methionine Sulfoxide Reductase MsrP.
Juillan-Binard C, Picciocchi A, Andrieu JP, Dupuy J, Petit-Hartlein I, Caux-Thang C, Vivès C, Nivière V, Fieschi F
J Biol Chem 2017 Feb 10;292:2485-2494

Autocatalytic association of proteins by covalent bond formation: a Bio Molecular Welding toolbox derived from a bacterial adhesin.
Bonnet J, Cartannaz J, Tourcier G, Contreras-Martel C, Kleman JP, Morlot C, Vernet T, Di Guilmi AM
Sci Rep 2017 Mar 2;7:43564

Automatic segmentation of high pressure frozen and freeze-substituted mouse retina nuclei from FIB-SEM tomograms.
Hoang TV, Kizilyaprak C, Spehner D, Humbel BM, Schultz P
J Struct Biol 2017 Feb;197:123-134

Bacteriophage T5 tail tube structure suggests a trigger mechanism for Siphoviridae DNA ejection.
Arnaud CA, Effantin G, Vivès C, Engilberge S, Bacia M, Boulanger P, Girard E, Schoehn G, Breyton C
Nat Commun 2017 Dec 5;8:1953

Biophysical analysis of Arabidopsis protein-only RNase P alone and in complex with tRNA provides a refined model of tRNA binding.
Pinker F, Schelcher C, Fernandez-Millan P, Gobert A, Birck C, Thureau A, Roblin P, Giegé P, Sauter C
J Biol Chem 2017 Aug 25;292:13904-13913

Calreticulin Release at an Early Stage of Death Modulates the Clearance by Macrophages of Apoptotic Cells.
Osman R, Tacnet-Delorme P, Kleman JP, Millet A, Frachet P
Front Immunol 2017 ;8:1034

Camelid nanobodies used as crystallization chaperones for different constructs of PorM, a component of the type IX secretion system from Porphyromonas gingivalis.
Duhoo Y, Roche J, Trinh TTN, Desmyter A, Gaubert A, Kellenberger C, Cambillau C, Roussel A, Leone P
Acta Crystallogr F Struct Biol Commun 2017 May 1;73:286-293

CASQ1 mutations impair calsequestrin polymerization and cause tubular aggregate myopathy.
Böhm J, Lornage X, Chevessier F, Birck C, Zanotti S, Cudia P, Bulla M, Granger F, Bui MT, Sartori M, Schneider-Gold C, Malfatti E, Romero NB, Mora M, Laporte J
Acta Neuropathol 2017 Oct 16;:

Catch bond drives stator mechanosensitivity in the bacterial flagellar motor.
Nord AL, Gachon E, Perez-Carrasco R, Nirody JA, Barducci A, Berry RM, Pedaci F
Proc Natl Acad Sci U S A 2017 Dec 5;114:12952-12957

CCL2 nitration is a negative regulator of chemokine-mediated inflammation.
Barker CE, Thompson S, O'Boyle G, Lortat-Jacob H, Sheerin NS, Ali S, Kirby JA
Sci Rep 2017 Mar 14;7:44384

Characterization of Cu(II)-reconstituted ACC Oxidase using experimental and theoretical approaches.
El Bakkali-Tahéri N, Tachon S, Orio M, Bertaina S, Martinho M, Robert V, Réglier M, Tron T, Dorlet P, Simaan AJ
Arch Biochem Biophys 2017 Jun 1;623-624:31-41

Concerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion.
Duroc Y, Kumar R, Ranjha L, Adam C, Guérois R, Md Muntaz K, Marsolier-Kergoat MC, Dingli F, Laureau R, Loew D, Llorente B, Charbonnier JB, Cejka P, Borde V
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Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2.
Karuppasamy M, Kusmider B, Oliveira TM, Gaubitz C, Prouteau M, Loewith R, Schaffitzel C
Nat Commun 2017 Nov 23;8:1729

Crystallization and Preliminary X-Ray Diffraction Analysis of a Mammal Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase.
Franco-Echevarría E, Sanz-Aparicio J, Troffer-Charlier N, Poterszman A, González B
Protein J 2017 Aug;36:240-248

Crystal Structure of the Chloroplastic Oxoene Reductase ceQORH from Arabidopsis thaliana.
Mas Y Mas S, Curien G, Giustini C, Rolland N, Ferrer JL, Cobessi D
Front Plant Sci 2017 ;8:329

Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding.
Volbeda A, Dodd EL, Darnault C, Crack JC, Renoux O, Hutchings MI, Le Brun NE, Fontecilla-Camps JC
Nat Commun 2017 Apr 20;8:15052

Cyclic imine toxins from dinoflagellates: a growing family of potent antagonists of the nicotinic acetylcholine receptors.
Molgó J, Marchot P, Aráoz R, Benoit E, Iorga BI, Zakarian A, Taylor P, Bourne Y, Servent D
J Neurochem 2017 Aug;142 Suppl 2:41-51

Deciphering Key Residues Involved in the Virulence-promoting Interactions between Streptococcus pneumoniae and Human Plasminogen.
Moreau C, Terrasse R, Thielens NM, Vernet T, Gaboriaud C, Di Guilmi AM
J Biol Chem 2017 Feb 10;292:2217-2225

Derivation of original RESP atomic partial charges for MD simulations of the LDAO surfactant with AMBER: applications to a model of micelle and a fragment of the lipid kinase PI4KA.
Karakas E, Taveneau C, Bressanelli S, Marchi M, Robert B, Abel S
J Biomol Struct Dyn 2017 Jan;35:159-181

Differential proteomics highlights macrophage-specific responses to amorphous silica nanoparticles.
Dalzon B, Aude-Garcia C, Collin-Faure V, Diemer H, Béal D, Dussert F, Fenel D, Schoehn G, Cianférani S, Carrière M, Rabilloud T
Nanoscale 2017 Jul 13;9:9641-9658

Disentangling polydispersity in the PCNA-p15PAF complex, a disordered, transient and multivalent macromolecular assembly.
Cordeiro TN, Chen PC, De Biasio A, Sibille N, Blanco FJ, Hub JS, Crehuet R, Bernadó P
Nucleic Acids Res 2017 Feb 17;45:1501-1515

Dissecting mechanism of coupled folding and binding of an intrinsically disordered protein by chemical synthesis of conformationally constrained analogues.
Schmidtgall B, Chaloin O, Bauer V, Sumyk M, Birck C, Torbeev V
Chem Commun (Camb) 2017 Jun 29;53:7369-7372

Dynamic Descriptions of Highly Flexible Molecules from NMR Dipolar Couplings: Physical Basis and Limitations.
Salvi N, Salmon L, Blackledge M
J Am Chem Soc 2017 Apr 12;139:5011-5014

Dynamics and energetics of cyanobacterial photosystem I:ferredoxin complexes in different redox states.
Sétif P, Mutoh R, Kurisu G
Biochim Biophys Acta Bioenerg 2017 Jul;1858:483-496

Dynamics of Methylated Cytosine Flipping by UHRF1.
Kilin V, Gavvala K, Barthes NP, Michel BY, Shin D, Boudier C, Mauffret O, Yashchuk V, Mousli M, Ruff M, Granger F, Eiler S, Bronner C, Tor Y, Burger A, Mély Y
J Am Chem Soc 2017 Feb 15;139:2520-2528

Effect of Phosphorylation on a Human-like Osteopontin Peptide.
Lenton S, Grimaldo M, Roosen-Runge F, Schreiber F, Nylander T, Clegg R, Holt C, Härtlein M, García Sakai V, Seydel T, Marujo Teixeira SC
Biophys J 2017 Apr 25;112:1586-1596

Efficient conversion of alkenes to chlorohydrins by a Ru-based artificial enzyme.
Lopez S, Rondot L, Cavazza C, Iannello M, Boeri-Erba E, Burzlaff N, Strinitz F, Jorge-Robin A, Marchi-Delapierre C, Ménage S
Chem Commun (Camb) 2017 Mar 23;53:3579-3582

Electronic and vibrational properties of carotenoids: from in vitro to in vivo.
Llansola-Portoles MJ, Pascal AA, Robert B
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Emerin self-assembly mechanism: role of the LEM domain.
Samson C, Celli F, Hendriks K, Zinke M, Essawy N, Herrada I, Arteni AA, Theillet FX, Alpha-Bazin B, Armengaud J, Coirault C, Lange A, Zinn-Justin S
FEBS J 2017 Jan;284:338-352

Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4.
Collins PJ, McCully ML, Martínez-Muñoz L, Santiago C, Wheeldon J, Caucheteux S, Thelen S, Cecchinato V, Laufer JM, Purvanov V, Monneau YR, Lortat-Jacob H, Legler DF, Uguccioni M, Thelen M, Piguet V, Mellado M, Moser B
FASEB J 2017 Jul;31:3084-3097

Evolved distal tail carbohydrate binding modules of Lactobacillus phage J-1: a novel type of anti-receptor widespread among lactic acid bacteria phages.
Dieterle ME, Spinelli S, Sadovskaya I, Piuri M, Cambillau C
Mol Microbiol 2017 May;104:608-620

Facile access to pseudo-thio-1,2-dimannoside, a new glycomimetic DC-SIGN antagonist.
Tamburrini A, Achilli S, Vasile F, Sattin S, Vivès C, Colombo C, Fieschi F, Bernardi A
Bioorg Med Chem 2017 Oct 1;25:5142-5147

Fast Collisional Lipid Transfer Among Polymer-Bounded Nanodiscs.
Cuevas Arenas R, Danielczak B, Martel A, Porcar L, Breyton C, Ebel C, Keller S
Sci Rep 2017 Apr 5;7:45875

Fast iodide-SAD phasing for high-throughput membrane protein structure determination.
Melnikov I, Polovinkin V, Kovalev K, Gushchin I, Shevtsov M, Shevchenko V, Mishin A, Alekseev A, Rodriguez-Valera F, Borshchevskiy V, Cherezov V, Leonard GA, Gordeliy V, Popov A
Sci Adv 2017 May;3:e1602952

Fitness costs restrict niche expansion by generalist niche-constructing pathogens.
Lang J, Vigouroux A, El Sahili A, Kwasiborski A, Aumont-Nicaise M, Dessaux Y, Shykoff JA, Moréra S, Faure D
ISME J 2017 Feb;11:374-385

Focused classification and refinement in high-resolution cryo-EM structural analysis of ribosome complexes.
von Loeffelholz O, Natchiar SK, Djabeur N, Myasnikov AG, Kratzat H, Ménétret JF, Hazemann I, Klaholz BP
Curr Opin Struct Biol 2017 Oct;46:140-148

Fragment-Based NMR Study of the Conformational Dynamics in the bHLH Transcription Factor Ascl1.
Baronti L, Hošek T, Gil-Caballero S, Raveh-Amit H, Calçada EO, Ayala I, Dinnyés A, Felli IC, Pierattelli R, Brutscher B
Biophys J 2017 Apr 11;112:1366-1373

Functional reconstitution of cell-free synthesized purified Kv channels.
Renauld S, Cortes S, Bersch B, Henry X, De Waard M, Schaack B
Biochim Biophys Acta Biomembr 2017 Dec;1859:2373-2380

Gallium ferredoxin as a tool to study the effects of ferredoxin binding to photosystem I without ferredoxin reduction.
Mignée C, Mutoh R, Krieger-Liszkay A, Kurisu G, Sétif P
Photosynth Res 2017 Dec;134:251-263

Giant light-harvesting nanoantenna for single-molecule detection in ambient light.
Trofymchuk K, Reisch A, Didier P, Fras F, Gilliot P, Mely Y, Klymchenko AS
Nat Photonics 2017 Oct;11:657-663

High phosphatidylinositol 4-phosphate (PI4P)-dependent ATPase activity for the Drs2p-Cdc50p flippase after removal of its N- and C-terminal extensions.
Azouaoui H, Montigny C, Dieudonné T, Champeil P, Jacquot A, Vázquez-Ibar JL, Le Maréchal P, Ulstrup J, Ash MR, Lyons JA, Nissen P, Lenoir G
J Biol Chem 2017 May 12;292:7954-7970

Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.
Anderson L, Gomes MR, daSilva LF, Pereira ADSA, Mourão MM, Romier C, Pierce R, Verjovski-Almeida S
PLoS Negl Trop Dis 2017 Apr;11:e0005539

Human Immune Protein C1q Selectively Disaggregates Carbon Nanotubes.
Saint-Cricq M, Carrete J, Gaboriaud C, Gravel E, Doris E, Thielens N, Mingo N, Ling WL
Nano Lett 2017 Jun 14;17:3409-3415

Identification of high-confidence RNA regulatory elements by combinatorial classification of RNA-protein binding sites.
Li YE, Xiao M, Shi B, Yang YT, Wang D, Wang F, Marcia M, Lu ZJ
Genome Biol 2017 Sep 8;18:169

Impact of fluorescent protein fusions on the bacterial flagellar motor.
Heo M, Nord AL, Chamousset D, van Rijn E, Beaumont HJE, Pedaci F
Sci Rep 2017 Oct 3;7:12583

Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor.
Mohideen-Abdul K, Tazibt K, Bourguet M, Hazemann I, Lebars I, Takacs M, Cianférani S, Klaholz BP, Moras D, Billas IML
Front Endocrinol (Lausanne) 2017 ;8:140

Indolizine-Based Scaffolds as Efficient and Versatile Tools: Application to the Synthesis of Biotin-Tagged Antiangiogenic Drugs.
Arvin-Berod M, Desroches-Castan A, Bonte S, Brugière S, Couté Y, Guyon L, Feige JJ, Baussanne I, Demeunynck M
ACS Omega 2017 Dec 31;2:9221-9230

In-plane molecular organization of hydrated single lipid bilayers: DPPC:cholesterol.
Gumí-Audenis B, Costa L, Redondo-Morata L, Milhiet PE, Sanz F, Felici R, Giannotti MI, Carlà F
Nanoscale 2017 Dec 21;10:87-92

Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin.
Wang W, Cantos-Fernandes S, Lv Y, Kuerban H, Ahmad S, Wang C, Gigant B
Nat Commun 2017 Jul 10;8:70

Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis.
Peng G, McEwen AG, Olieric V, Schmitt C, Albrecht S, Cavarelli J, Tarnus C
Proteins 2017 Aug;85:1413-1421

Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases.
Lacroix M, Tessier A, Dumestre-Pérard C, Vadon-Le Goff S, Gout E, Bruckner-Tuderman L, Kiritsi D, Nyström A, Ricard-Blum S, Moali C, Hulmes DJS, Thielens NM
Sci Rep 2017 Dec 5;7:16958

Interaction of lipopolysaccharides at intermolecular sites of the periplasmic Lpt transport assembly.
Laguri C, Sperandeo P, Pounot K, Ayala I, Silipo A, Bougault CM, Molinaro A, Polissi A, Simorre JP
Sci Rep 2017 Aug 29;7:9715

Intramolecular Photogeneration of a Tyrosine Radical in a Designed Protein.
Tebo AG, Quaranta A, Herrero C, Pecoraro VL, Aukauloo A
ChemPhotoChem 2017 Mar;1:89-92

Inward H+ pump xenorhodopsin: Mechanism and alternative optogenetic approach.
Shevchenko V, Mager T, Kovalev K, Polovinkin V, Alekseev A, Juettner J, Chizhov I, Bamann C, Vavourakis C, Ghai R, Gushchin I, Borshchevskiy V, Rogachev A, Melnikov I, Popov A, Balandin T, Rodriguez-Valera F, Manstein DJ, Bueldt G, Bamberg E, Gordeliy V
Sci Adv 2017 Sep;3:e1603187

1H, 13C and 15N backbone chemical shift assignments of camelid single-domain antibodies against active state µ-opioid receptor.
Sounier R, Yang Y, Hagelberger J, Granier S, Déméné H
Biomol NMR Assign 2017 Apr;11:117-121

Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form.
Bruno S, Margiotta M, Marchesani F, Paredi G, Orlandi V, Faggiano S, Ronda L, Campanini B, Mozzarelli A
Biochim Biophys Acta Proteins Proteom 2017 Apr;1865:381-387

Mannosylcalix[n]arenes as multivalent ligands for DC-SIGN.
Morbioli I, Porkolab V, Magini A, Casnati A, Fieschi F, Sansone F
Carbohydr Res 2017 Dec 1;453-454:36-43

Matchout deuterium labelling of proteins for small-angle neutron scattering studies using prokaryotic and eukaryotic expression systems and high cell-density cultures.
Dunne O, Weidenhaupt M, Callow P, Martel A, Moulin M, Perkins SJ, Haertlein M, Forsyth VT
Eur Biophys J 2017 Jul;46:425-432

Mechanism of transmembrane signaling by sensor histidine kinases.
Gushchin I, Melnikov I, Polovinkin V, Ishchenko A, Yuzhakova A, Buslaev P, Bourenkov G, Grudinin S, Round E, Balandin T, Borshchevskiy V, Willbold D, Leonard G, Büldt G, Popov A, Gordeliy V
Science 2017 Jun 9;356:

Membrane Permeation versus Amyloidogenicity: A Multitechnique Study of Islet Amyloid Polypeptide Interaction with Model Membranes.
Martel A, Antony L, Gerelli Y, Porcar L, Fluitt A, Hoffmann K, Kiesel I, Vivaudou M, Fragneto G, de Pablo JJ
J Am Chem Soc 2017 Jan 11;139:137-148

Microtome-integrated microscope system for high sensitivity tracking of in-resin fluorescence in blocks and ultrathin sections for correlative microscopy.
Lemercier N, Middel V, Hentsch D, Taubert S, Takamiya M, Beil T, Vonesch JL, Baumbach T, Schultz P, Antony C, Strähle U
Sci Rep 2017 Oct 19;7:13583

Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration.
Matysiak J, Lesbats P, Mauro E, Lapaillerie D, Dupuy JW, Lopez AP, Benleulmi MS, Calmels C, Andreola ML, Ruff M, Llano M, Delelis O, Lavigne M, Parissi V
Retrovirology 2017 Jul 28;14:39

Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails.
Benleulmi MS, Matysiak J, Robert X, Miskey C, Mauro E, Lapaillerie D, Lesbats P, Chaignepain S, Henriquez DR, Calmels C, Oladosu O, Thierry E, Leon O, Lavigne M, Andreola ML, Delelis O, Ivics Z, Ruff M, Gouet P, Parissi V
Retrovirology 2017 Nov 28;14:54

Molecular architecture of the PBP2-MreC core bacterial cell wall synthesis complex.
Contreras-Martel C, Martins A, Ecobichon C, Trindade DM, Matteï PJ, Hicham S, Hardouin P, Ghachi ME, Boneca IG, Dessen A
Nat Commun 2017 Oct 3;8:776

Monitoring protein folding through high pressure NMR spectroscopy.
Roche J, Royer CA, Roumestand C
Prog Nucl Magn Reson Spectrosc 2017 Nov;102-103:15-31

Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1).
Sukackaite R, Cornacchia D, Jensen MR, Mas PJ, Blackledge M, Enervald E, Duan G, Auchynnikava T, Köhn M, Hart DJ, Buonomo SBC
Sci Rep 2017 May 18;7:2119

Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting.
Pansieri J, Plissonneau M, Stransky-Heilkron N, Dumoulin M, Heinrich-Balard L, Rivory P, Morfin JF, Toth E, Saraiva MJ, Allémann E, Tillement O, Forge V, Lux F, Marquette C
Nanomedicine (Lond) 2017 Jul;12:1675-1687

New insights into HCV replication in original cells from Aedes mosquitoes.
Fallecker C, Caporossi A, Rechoum Y, Garzoni F, Larrat S, François O, Fender P, Morand P, Berger I, Petit MA, Drouet E
Virol J 2017 Aug 22;14:161

New Insights on Signal Propagation by Sensory Rhodopsin II/Transducer Complex.
Ishchenko A, Round E, Borshchevskiy V, Grudinin S, Gushchin I, Klare JP, Remeeva A, Polovinkin V, Utrobin P, Balandin T, Engelhard M, Büldt G, Gordeliy V
Sci Rep 2017 Feb 6;7:41811

Non-equilibrium steady states in supramolecular polymerization.
Sorrenti A, Leira-Iglesias J, Sato A, Hermans TM
Nat Commun 2017 Jun 19;8:15899

Observation of CH⋅⋅⋅π Interactions between Methyl and Carbonyl Groups in Proteins.
Perras FA, Marion D, Boisbouvier J, Bryce DL, Plevin MJ
Angew Chem Int Ed Engl 2017 Jun 19;56:7564-7567

Online Raman spectroscopy for structural biology on beamline ID29 of the ESRF.
von Stetten D, Giraud T, Bui S, Steiner RA, Fihman F, de Sanctis D, Royant A
J Struct Biol 2017 Nov;200:124-127

Optimized fast mixing device for real-time NMR applications.
Franco R, Favier A, Schanda P, Brutscher B
J Magn Reson 2017 Aug;281:125-129

Paralogs of the C-Terminal Domain of the Cyanobacterial Orange Carotenoid Protein Are Carotenoid Donors to Helical Carotenoid Proteins.
Muzzopappa F, Wilson A, Yogarajah V, Cot S, Perreau F, Montigny C, Bourcier de Carbon C, Kirilovsky D
Plant Physiol 2017 Nov;175:1283-1303

PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo.
Aldrian G, Vaissière A, Konate K, Seisel Q, Vivès E, Fernandez F, Viguier V, Genevois C, Couillaud F, Démèné H, Aggad D, Covinhes A, Barrère-Lemaire S, Deshayes S, Boisguerin P
J Control Release 2017 Jun 28;256:79-91

Peptidoglycan O-acetylation is functionally related to cell wall biosynthesis and cell division in Streptococcus pneumoniae.
Bonnet J, Durmort C, Jacq M, Mortier-Barrière I, Campo N, VanNieuwenhze MS, Brun YV, Arthaud C, Gallet B, Moriscot C, Morlot C, Vernet T, Di Guilmi AM
Mol Microbiol 2017 Dec;106:832-846

Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides.
Wutz D, Gluhacevic D, Chakrabarti A, Schmidtkunz K, Robaa D, Erdmann F, Romier C, Sippl W, Jung M, König B
Org Biomol Chem 2017 Jun 7;15:4882-4896

Photoswitching of Green mEos2 by Intense 561 nm Light Perturbs Efficient Green-to-Red Photoconversion in Localization Microscopy.
Thédié D, Berardozzi R, Adam V, Bourgeois D
J Phys Chem Lett 2017 Sep 21;8:4424-4430

Pigment structure in the violaxanthin-chlorophyll-a-binding protein VCP.
Llansola-Portoles MJ, Litvin R, Ilioaia C, Pascal AA, Bina D, Robert B
Photosynth Res 2017 Oct;134:51-58

Plastid thylakoid architecture optimizes photosynthesis in diatoms.
Flori S, Jouneau PH, Bailleul B, Gallet B, Estrozi LF, Moriscot C, Bastien O, Eicke S, Schober A, Bártulos CR, Maréchal E, Kroth PG, Petroutsos D, Zeeman S, Breyton C, Schoehn G, Falconet D, Finazzi G
Nat Commun 2017 Jun 20;8:15885

Polyvalent C-glycomimetics based on l-fucose or d-mannose as potent DC-SIGN antagonists.
Bertolotti B, Sutkeviciute I, Ambrosini M, Ribeiro-Viana R, Rojo J, Fieschi F, Dvořáková H, Kašáková M, Parkan K, Hlaváčková M, Nováková K, Moravcová J
Org Biomol Chem 2017 May 10;15:3995-4004

Probing Conformational Exchange Dynamics in a Short-Lived Protein Folding Intermediate by Real-Time Relaxation-Dispersion NMR.
Franco R, Gil-Caballero S, Ayala I, Favier A, Brutscher B
J Am Chem Soc 2017 Jan 25;139:1065-1068

Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components.
Ong LL, Hanikel N, Yaghi OK, Grun C, Strauss MT, Bron P, Lai-Kee-Him J, Schueder F, Wang B, Wang P, Kishi JY, Myhrvold C, Zhu A, Jungmann R, Bellot G, Ke Y, Yin P
Nature 2017 Dec 6;552:72-77

Protein conformational dynamics studied by 15N and 1H R1ρ relaxation dispersion: Application to wild-type and G53A ubiquitin crystals.
Gauto DF, Hessel A, Rovó P, Kurauskas V, Linser R, Schanda P
Solid State Nucl Magn Reson 2017 Oct;87:86-95

Proton-Detected Solid-State NMR Spectroscopy of a Zinc Diffusion Facilitator Protein in Native Nanodiscs.
Bersch B, Dörr JM, Hessel A, Killian JA, Schanda P
Angew Chem Int Ed Engl 2017 Feb 20;56:2508-2512

Pseudomonas aeruginosa Exolysin promotes bacterial growth in lungs, alveolar damage and bacterial dissemination.
Bouillot S, Munro P, Gallet B, Reboud E, Cretin F, Golovkine G, Schoehn G, Attrée I, Lemichez E, Huber P
Sci Rep 2017 May 18;7:2120

Recognition of the Magnaporthe oryzae Effector AVR-Pia by the Decoy Domain of the Rice NLR Immune Receptor RGA5.
Ortiz D, de Guillen K, Cesari S, Chalvon V, Gracy J, Padilla A, Kroj T
Plant Cell 2017 Jan;29:156-168

Reversible Bioconjugation: Biodegradable Poly(phosphate)-Protein Conjugates.
Steinbach T, Becker G, Spiegel A, Figueiredo T, Russo D, Wurm FR
Macromol Biosci 2017 Oct;17:

Revisiting the Val/Ile Mutation in Mammalian and Bacterial Nitric Oxide Synthases: A Spectroscopic and Kinetic Study.
Weisslocker-Schaetzel M, Lembrouk M, Santolini J, Dorlet P
Biochemistry 2017 Feb 7;56:748-756

RNA binding and chaperone activity of the E. coli cold-shock protein CspA.
Rennella E, Sára T, Juen M, Wunderlich C, Imbert L, Solyom Z, Favier A, Ayala I, Weinhäupl K, Schanda P, Konrat R, Kreutz C, Brutscher B
Nucleic Acids Res 2017 Apr 20;45:4255-4268

SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation.
Gribling-Burrer AS, Leichter M, Wurth L, Huttin A, Schlotter F, Troffer-Charlier N, Cura V, Barkats M, Cavarelli J, Massenet S, Allmang C
Nucleic Acids Res 2017 May 19;45:5399-5413

Secondary-Rim γ-Cyclodextrin Functionalization to Conjugate with C60 : Improved Efficacy as a Photosensitizer.
Zhu X, Quaranta A, Bensasson RV, Sollogoub M, Zhang Y
Chemistry 2017 Jul 18;23:9462-9466

Selective BET bromodomain inhibition as an antifungal therapeutic strategy.
Mietton F, Ferri E, Champleboux M, Zala N, Maubon D, Zhou Y, Harbut M, Spittler D, Garnaud C, Courçon M, Chauvel M, d'Enfert C, Kashemirov BA, Hull M, Cornet M, McKenna CE, Govin J, Petosa C
Nat Commun 2017 May 18;8:15482

Self-association of a highly charged arginine-rich cell-penetrating peptide.
Tesei G, Vazdar M, Jensen MR, Cragnell C, Mason PE, Heyda J, Skepö M, Jungwirth P, Lund M
Proc Natl Acad Sci U S A 2017 Oct 24;114:11428-11433

Slow conformational exchange and overall rocking motion in ubiquitin protein crystals.
Kurauskas V, Izmailov SA, Rogacheva ON, Hessel A, Ayala I, Woodhouse J, Shilova A, Xue Y, Yuwen T, Coquelle N, Colletier JP, Skrynnikov NR, Schanda P
Nat Commun 2017 Jul 27;8:145

Slow Phospholipid Exchange between a Detergent-Solubilized Membrane Protein and Lipid-Detergent Mixed Micelles: Brominated Phospholipids as Tools to Follow Its Kinetics.
Montigny C, Dieudonné T, Orlowski S, Vázquez-Ibar JL, Gauron C, Georgin D, Lund S, le Maire M, Møller JV, Champeil P, Lenoir G
PLoS One 2017 ;12:e0170481

Small-angle scattering studies of intrinsically disordered proteins and their complexes.
Cordeiro TN, Herranz-Trillo F, Urbanek A, Estaña A, Cortés J, Sibille N, Bernadó P
Curr Opin Struct Biol 2017 Feb;42:15-23

Solid-State NMR H-N-(C)-H and H-N-C-C 3D/4D Correlation Experiments for Resonance Assignment of Large Proteins.
Fraga H, Arnaud CA, Gauto DF, Audin M, Kurauskas V, Macek P, Krichel C, Guan JY, Boisbouvier J, Sprangers R, Breyton C, Schanda P
Chemphyschem 2017 Oct 6;18:2697-2703

Solubilization of lipids and lipid phases by the styrene-maleic acid copolymer.
Dominguez Pardo JJ, Dörr JM, Iyer A, Cox RC, Scheidelaar S, Koorengevel MC, Subramaniam V, Killian JA
Eur Biophys J 2017 Jan;46:91-101

Solution structure of CXCL13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains.
Monneau YR, Luo L, Sankaranarayanan NV, Nagarajan B, Vivès RR, Baleux F, Desai UR, Arenzana-Seidedos F, Lortat-Jacob H
Open Biol 2017 Oct;7:

Specific and spatial labeling of choline-containing teichoic acids in Streptococcus pneumoniae by click chemistry.
Di Guilmi AM, Bonnet J, Peiβert S, Durmort C, Gallet B, Vernet T, Gisch N, Wong YS
Chem Commun (Camb) 2017 Sep 21;53:10572-10575

Speed of the bacterial flagellar motor near zero load depends on the number of stator units.
Nord AL, Sowa Y, Steel BC, Lo CJ, Berry RM
Proc Natl Acad Sci U S A 2017 Oct 31;114:11603-11608

Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D.
Belorusova AY, Suh N, Lee HJ, So JY, Maehr H, Rochel N
J Steroid Biochem Mol Biol 2017 Oct;173:69-74

Structural Analysis of Multi-component Amyloid Systems by Chemometric SAXS Data Decomposition.
Herranz-Trillo F, Groenning M, van Maarschalkerweerd A, Tauler R, Vestergaard B, Bernadó P
Structure 2017 Jan 3;25:5-15

Structural analysis of the complex between influenza B nucleoprotein and human importin-α.
Labaronne A, Milles S, Donchet A, Jensen MR, Blackledge M, Bourhis JM, Ruigrok RWH, Crépin T
Sci Rep 2017 Dec 7;7:17164

Structural and functional evidences for the interactions between nuclear hormone receptors and endocrine disruptors at low doses.
Balaguer P, Delfosse V, Grimaldi M, Bourguet W
C R Biol 2017 Sep - Oct;340:414-420

Structural and functional insights into the periplasmic detector domain of the GacS histidine kinase controlling biofilm formation in Pseudomonas aeruginosa.
Ali-Ahmad A, Fadel F, Sebban-Kreuzer C, Ba M, Pélissier GD, Bornet O, Guerlesquin F, Bourne Y, Bordi C, Vincent F
Sci Rep 2017 Sep 12;7:11262

Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2.
Schulze WM, Cusack S
Nat Commun 2017 Nov 3;8:1302

Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008.
Ruiz FX, Crespo I, Álvarez S, Porté S, Giménez-Dejoz J, Cousido-Siah A, Mitschler A, de Lera ÁR, Parés X, Podjarny A, Farrés J
Chem Biol Interact 2017 Oct 1;276:174-181

Structural basis for the substrate selectivity of Helicobacter pylori NucT nuclease activity.
Celma L, Corbinais C, Vercruyssen J, Veaute X, de la Sierra-Gallay IL, Guérois R, Busso D, Mathieu A, Marsin S, Quevillon-Cheruel S, Radicella JP
PLoS One 2017 ;12:e0189049

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.
Pellegrini E, Palencia A, Braun L, Kapp U, Bougdour A, Belrhali H, Bowler MW, Hakimi MA
Structure 2017 Jan 3;25:16-26

Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48.
Moreno-Beltrán B, Guerra-Castellano A, Díaz-Quintana A, Del Conte R, García-Mauriño SM, Díaz-Moreno S, González-Arzola K, Santos-Ocaña C, Velázquez-Campoy A, De la Rosa MA, Turano P, Díaz-Moreno I
Proc Natl Acad Sci U S A 2017 Apr 11;114:E3041-E3050

Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7.
Desravines DC, Serna Martin I, Schneider R, Mas PJ, Aleksandrova N, Jensen MR, Blackledge M, Hart DJ
Sci Rep 2017 Jun 16;7:3678

Structural Insight into Ubiquitin-Like Protein Recognition and Oligomeric States of JAMM/MPN+ Proteases.
Cao S, Engilberge S, Girard E, Gabel F, Franzetti B, Maupin-Furlow JA
Structure 2017 Jun 6;25:823-833.e6

Structural insights into a family 39 glycoside hydrolase from the gut symbiont Bacteroides cellulosilyticus WH2.
Ali-Ahmad A, Garron ML, Zamboni V, Lenfant N, Nurizzo D, Henrissat B, Berrin JG, Bourne Y, Vincent F
J Struct Biol 2017 Mar;197:227-235

Structural insights into ion conduction by channelrhodopsin 2.
Volkov O, Kovalev K, Polovinkin V, Borshchevskiy V, Bamann C, Astashkin R, Marin E, Popov A, Balandin T, Willbold D, Büldt G, Bamberg E, Gordeliy V
Science 2017 Nov 24;358:

Structural insights into the architecture of the Shigella flexneri virulence factor IcsA/VirG and motifs involved in polar distribution and secretion.
Leupold S, Büsing P, Mas PJ, Hart DJ, Scrima A
J Struct Biol 2017 Apr;198:19-27

Structural Insights into the Nature of Fe0 and FeI Low-Valent Species Obtained upon the Reduction of Iron Salts by Aryl Grignard Reagents.
Clémancey M, Cantat T, Blondin G, Latour JM, Dorlet P, Lefèvre G
Inorg Chem 2017 Apr 3;56:3834-3848

Structural insights into the substrate recognition and reaction specificity of the PLP-dependent fold-type I isoleucine 2-epimerase from Lactobacillus buchneri.
Awad R, Gans P, Reiser JB
Biochimie 2017 Jun;137:165-173

Structural intermediates in the fusion-associated transition of vesiculovirus glycoprotein.
Baquero E, Albertini AA, Raux H, Abou-Hamdan A, Boeri-Erba E, Ouldali M, Buonocore L, Rose JK, Lepault J, Bressanelli S, Gaudin Y
EMBO J 2017 Mar 1;36:679-692

Structural plasticity of the N-terminal capping helix of the TPR domain of kinesin light chain.
Nguyen TQ, Chenon M, Vilela F, Velours C, Aumont-Nicaise M, Andreani J, Varela PF, Llinas P, Ménétrey J
PLoS One 2017 ;12:e0186354

Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors.
Cura V, Marechal N, Troffer-Charlier N, Strub JM, van Haren MJ, Martin NI, Cianférani S, Bonnefond L, Cavarelli J
FEBS J 2017 Jan;284:77-96

Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants.
Noguera ME, Vazquez DS, Ferrer-Sueta G, Agudelo WA, Howard E, Rasia RM, Manta B, Cousido-Siah A, Mitschler A, Podjarny A, Santos J
Sci Rep 2017 Feb 9;7:42343

Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain.
Belorusova AY, Martínez A, Gándara Z, Gómez G, Fall Y, Rochel N
Eur J Med Chem 2017 Jul 7;134:86-96

Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1.
Bednar J, Garcia-Saez I, Boopathi R, Cutter AR, Papai G, Reymer A, Syed SH, Lone IN, Tonchev O, Crucifix C, Menoni H, Papin C, Skoufias DA, Kurumizaka H, Lavery R, Hamiche A, Hayes JJ, Schultz P, Angelov D, Petosa C, Dimitrov S
Mol Cell 2017 May 4;66:384-397.e8

Structure of human lysosomal acid α-glucosidase-a guide for the treatment of Pompe disease.
Roig-Zamboni V, Cobucci-Ponzano B, Iacono R, Ferrara MC, Germany S, Bourne Y, Parenti G, Moracci M, Sulzenbacher G
Nat Commun 2017 Oct 24;8:1111

Structure of p300 in complex with acyl-CoA variants.
Kaczmarska Z, Ortega E, Goudarzi A, Huang H, Kim S, Márquez JA, Zhao Y, Khochbin S, Panne D
Nat Chem Biol 2017 Jan;13:21-29

Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA.
Sharov G, Voltz K, Durand A, Kolesnikova O, Papai G, Myasnikov AG, Dejaegere A, Ben Shem A, Schultz P
Nat Commun 2017 Nov 16;8:1556

Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF.
Khusainov I, Vicens Q, Ayupov R, Usachev K, Myasnikov A, Simonetti A, Validov S, Kieffer B, Yusupova G, Yusupov M, Hashem Y
EMBO J 2017 Jul 14;36:2073-2087

Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
Pellegrini E, Signor L, Singh S, Boeri Erba E, Cusack S
PLoS One 2017 ;12:e0177161

Substitutions in PBP2b from β-Lactam-resistant Streptococcus pneumoniae Have Different Effects on Enzymatic Activity and Drug Reactivity.
Calvez P, Breukink E, Roper DI, Dib M, Contreras-Martel C, Zapun A
J Biol Chem 2017 Feb 17;292:2854-2865

The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function.
Franco-Echevarría E, Sanz-Aparicio J, Brearley CA, González-Rubio JM, González B
J Biol Chem 2017 Jun 23;292:10534-10548

The crystal structure of the 5΄ functional domain of the transcription riboregulator 7SK.
Martinez-Zapien D, Legrand P, McEwen AG, Proux F, Cragnolini T, Pasquali S, Dock-Bregeon AC
Nucleic Acids Res 2017 Apr 7;45:3568-3579

The crystal structure of Trz1, the long form RNase Z from yeast.
Ma M, Li de la Sierra-Gallay I, Lazar N, Pellegrini O, Durand D, Marchfelder A, Condon C, van Tilbeurgh H
Nucleic Acids Res 2017 Jun 2;45:6209-6216

The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation.
Grzela R, Nusbaum J, Fieulaine S, Lavecchia F, Bienvenut WV, Dian C, Meinnel T, Giglione C
Sci Rep 2017 Sep 8;7:11041

The effectiveness of styrene-maleic acid (SMA) copolymers for solubilisation of integral membrane proteins from SMA-accessible and SMA-resistant membranes.
Swainsbury DJK, Scheidelaar S, Foster N, van Grondelle R, Killian JA, Jones MR
Biochim Biophys Acta Biomembr 2017 Oct;1859:2133-2143

The First State in the Catalytic Cycle of the Water-Oxidizing Enzyme: Identification of a Water-Derived μ-Hydroxo Bridge.
Lohmiller T, Krewald V, Sedoud A, Rutherford AW, Neese F, Lubitz W, Pantazis DA, Cox N
J Am Chem Soc 2017 Oct 18;139:14412-14424

The Henipavirus V protein is a prevalently unfolded protein with a zinc-finger domain involved in binding to DDB1.
Salladini E, Delauzun V, Longhi S
Mol Biosyst 2017 Oct 24;13:2254-2267

The integrative role of cryo electron microscopy in molecular and cellular structural biology.
Orlov I, Myasnikov AG, Andronov L, Natchiar SK, Khatter H, Beinsteiner B, Ménétret JF, Hazemann I, Mohideen K, Tazibt K, Tabaroni R, Kratzat H, Djabeur N, Bruxelles T, Raivoniaina F, Pompeo LD, Torchy M, Billas I, Urzhumtsev A, Klaholz BP
Biol Cell 2017 Feb;109:81-93

The intricate network between the p34 and p44 subunits is central to the activity of the transcription/DNA repair factor TFIIH.
Radu L, Schoenwetter E, Braun C, Marcoux J, Koelmel W, Schmitt DR, Kuper J, Cianférani S, Egly JM, Poterszman A, Kisker C
Nucleic Acids Res 2017 Oct 13;45:10872-10883

The Matrix protein M1 from influenza C virus induces tubular membrane invaginations in an in vitro cell membrane model.
Saletti D, Radzimanowski J, Effantin G, Midtvedt D, Mangenot S, Weissenhorn W, Bassereau P, Bally M
Sci Rep 2017 Jan 25;7:40801

The metastasis suppressor KISS1 is an intrinsically disordered protein slightly more extended than a random coil.
Ibáñez de Opakua A, Merino N, Villate M, Cordeiro TN, Ormaza G, Sánchez-Carbayo M, Diercks T, Bernadó P, Blanco FJ
PLoS One 2017 ;12:e0172507

The NOX Family of Proteins Is Also Present in Bacteria.
Hajjar C, Cherrier MV, Dias Mirandela G, Petit-Hartlein I, Stasia MJ, Fontecilla-Camps JC, Fieschi F, Dupuy J
MBio 2017 Nov 7;8:

Therapeutic effects of proteoliposomes on X-linked chronic granulomatous disease: proof of concept using macrophages differentiated from patient-specific induced pluripotent stem cells.
Brault J, Vaganay G, Le Roy A, Lenormand JL, Cortes S, Stasia MJ
Int J Nanomedicine 2017 ;12:2161-2177

The Ribosome Holds the RNA Polymerase on Track in Bacteria.
Klaholz BP
Trends Biochem Sci 2017 Sep;42:686-689

Thermotropic properties of phosphatidylcholine nanodiscs bounded by styrene-maleic acid copolymers.
Dominguez Pardo JJ, Dörr JM, Renne MF, Ould-Braham T, Koorengevel MC, van Steenbergen MJ, Killian JA
Chem Phys Lipids 2017 Nov;208:58-64

The structural switch of nucleotide-free kinesin.
Cao L, Cantos-Fernandes S, Gigant B
Sci Rep 2017 Feb 14;7:42558

The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.
Tellier-Lebegue C, Dizet E, Ma E, Veaute X, Coïc E, Charbonnier JB, Maloisel L
PLoS Genet 2017 Dec;13:e1007119

The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ.
Loiseau L, Fyfe C, Aussel L, Hajj Chehade M, Hernández SB, Faivre B, Hamdane D, Mellot-Draznieks C, Rascalou B, Pelosi L, Velours C, Cornu D, Lombard M, Casadesús J, Pierrel F, Fontecave M, Barras F
J Biol Chem 2017 Jul 14;292:11937-11950

The vaccinia virus DNA polymerase structure provides insights into the mode of processivity factor binding.
Tarbouriech N, Ducournau C, Hutin S, Mas PJ, Man P, Forest E, Hart DJ, Peyrefitte CN, Burmeister WP, Iseni F
Nat Commun 2017 Nov 13;8:1455

Time-resolved neutron scattering provides new insight into protein substrate processing by a AAA+ unfoldase.
Ibrahim Z, Martel A, Moulin M, Kim HS, Härtlein M, Franzetti B, Gabel F
Sci Rep 2017 Jan 19;7:40948

Toscana virus nucleoprotein oligomer organization observed in solution.
Baklouti A, Goulet A, Lichière J, Canard B, Charrel RN, Ferron F, Coutard B, Papageorgiou N
Acta Crystallogr D Struct Biol 2017 Aug 1;73:650-659

Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.
van Haren MJ, Marechal N, Troffer-Charlier N, Cianciulli A, Sbardella G, Cavarelli J, Martin NI
Proc Natl Acad Sci U S A 2017 Apr 4;114:3625-3630

Triplet-triplet energy transfer in artificial and natural photosynthetic antennas.
Ho J, Kish E, Méndez-Hernández DD, WongCarter K, Pillai S, Kodis G, Niklas J, Poluektov OG, Gust D, Moore TA, Moore AL, Batista VS, Robert B
Proc Natl Acad Sci U S A 2017 Jul 11;114:E5513-E5521

Trz1, the long form RNase Z from yeast, forms a stable heterohexamer with endonuclease Nuc1 and mutarotase.
Ma M, Li de la Sierra-Gallay I, Lazar N, Pellegrini O, Lepault J, Condon C, Durand D, van Tilbeurgh H
Biochem J 2017 Oct 18;474:3599-3613

Twisting a β-Carotene, an Adaptive Trick from Nature for Dissipating Energy during Photoprotection.
Llansola-Portoles MJ, Sobotka R, Kish E, Shukla MK, Pascal AA, Polívka T, Robert B
J Biol Chem 2017 Jan 27;292:1396-1403

Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nguyen VS, Logger L, Spinelli S, Legrand P, Huyen Pham TT, Nhung Trinh TT, Cherrak Y, Zoued A, Desmyter A, Durand E, Roussel A, Kellenberger C, Cascales E, Cambillau C
Nat Microbiol 2017 Jun 26;2:17103

Ultrafast flavin photoreduction in an oxidized animal (6-4) photolyase through an unconventional tryptophan tetrad.
Martin R, Lacombat F, Espagne A, Dozova N, Plaza P, Yamamoto J, Müller P, Brettel K, de la Lande A
Phys Chem Chem Phys 2017 Sep 20;19:24493-24504

Unraveling self-assembly pathways of the 468-kDa proteolytic machine TET2.
Macek P, Kerfah R, Boeri Erba E, Crublet E, Moriscot C, Schoehn G, Amero C, Boisbouvier J
Sci Adv 2017 Apr;3:e1601601

Unraveling the Self-Assembly of the Pseudomonas aeruginosa XcpQ Secretin Periplasmic Domain Provides New Molecular Insights into Type II Secretion System Secreton Architecture and Dynamics.
Douzi B, Trinh NTT, Michel-Souzy S, Desmyter A, Ball G, Barbier P, Kosta A, Durand E, Forest KT, Cambillau C, Roussel A, Voulhoux R
MBio 2017 Oct 17;8:

Unravelling the Molecular Basis of High Affinity Nanobodies against HIV p24: In Vitro Functional, Structural, and in Silico Insights.
Gray ER, Brookes JC, Caillat C, Turbé V, Webb BLJ, Granger LA, Miller BS, McCoy LE, El Khattabi M, Verrips CT, Weiss RA, Duffy DM, Weissenhorn W, McKendry RA
ACS Infect Dis 2017 Jul 14;3:479-491

Visualization of chemical modifications in the human 80S ribosome structure.
Natchiar SK, Myasnikov AG, Kratzat H, Hazemann I, Klaholz BP
Nature 2017 Nov 15;:

αRep A3: A Versatile Artificial Scaffold for Metalloenzyme Design.
Di Meo T, Ghattas W, Herrero C, Velours C, Minard P, Mahy JP, Ricoux R, Urvoas A
Chemistry 2017 Jul 26;23:10156-10166

2016 publications

8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode.
Paoletti J, Assairi L, Gelin M, Huteau V, Nahori MA, Dussurget O, Labesse G, Pochet S
Eur J Med Chem 2016 Nov 29;124:1041-1056

A Bis-Manganese(II)-DOTA Complex for Pulsed Dipolar Spectroscopy.
Demay-Drouhard P, Ching HY, Akhmetzyanov D, Guillot R, Tabares LC, Bertrand HC, Policar C
Chemphyschem 2016 Jul 4;17:2066-78

A central cavity within the holo-translocon suggests a mechanism for membrane protein insertion.
Botte M, Zaccai NR, Nijeholt JL, Martin R, Knoops K, Papai G, Zou J, Deniaud A, Karuppasamy M, Jiang Q, Roy AS, Schulten K, Schultz P, Rappsilber J, Zaccai G, Berger I, Collinson I, Schaffitzel C
Sci Rep 2016 Dec 7;6:38399

A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation.
Connell BJ, Chang SY, Prakash E, Yousfi R, Mohan V, Posch W, Wilflingseder D, Moog C, Kodama EN, Clayette P, Lortat-Jacob H
PLoS One 2016 ;11:e0165386

A heme-binding domain controls regulation of ATP-dependent potassium channels.
Burton MJ, Kapetanaki SM, Chernova T, Jamieson AG, Dorlet P, Santolini J, Moody PC, Mitcheson JS, Davies NW, Schmid R, Raven EL, Storey NM
Proc Natl Acad Sci U S A 2016 Apr 5;113:3785-90

A higher-order entity formed by the flexible assembly of RAP1 with TRF2.
Gaullier G, Miron S, Pisano S, Buisson R, Le Bihan YV, Tellier-Lebègue C, Messaoud W, Roblin P, Guimarães BG, Thai R, Giraud-Panis MJ, Gilson E, Le Du MH
Nucleic Acids Res 2016 Feb 29;44:1962-76

Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study.
Kaplan E, Guichou JF, Chaloin L, Kunzelmann S, Leban N, Serpersu EH, Lionne C
Biochim Biophys Acta 2016 Apr;1860:802-13

An avian influenza H5N1 virus vaccine candidate based on the extracellular domain produced in yeast system as subviral particles protects chickens from lethal challenge.
Pietrzak M, Macioła A, Zdanowski K, Protas-Klukowska AM, Olszewska M, Śmietanka K, Minta Z, Szewczyk B, Kopera E
Antiviral Res 2016 Sep;133:242-9

An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb.
Kobbi L, Demey-Thomas E, Braye F, Proux F, Kolesnikova O, Vinh J, Poterszman A, Bensaude O
Proc Natl Acad Sci U S A 2016 Oct 25;:

Arginine 66 Controls Dark-State Formation in Green-to-Red Photoconvertible Fluorescent Proteins.
Berardozzi R, Adam V, Martins A, Bourgeois D
J Am Chem Soc 2016 Jan 20;138:558-65

A ring-shaped conduit connects the mother cell and forespore during sporulation in Bacillus subtilis.
Rodrigues CD, Henry X, Neumann E, Kurauskas V, Bellard L, Fichou Y, Schanda P, Schoehn G, Rudner DZ, Morlot C
Proc Natl Acad Sci U S A 2016 Oct 11;113:11585-11590

A SAM oligomerization domain shapes the genomic binding landscape of the LEAFY transcription factor.
Sayou C, Nanao MH, Jamin M, Posé D, Thévenon E, Grégoire L, Tichtinsky G, Denay G, Ott F, Peirats Llobet M, Schmid M, Dumas R, Parcy F
Nat Commun 2016 Apr 21;7:11222

A simple acoustofluidic chip for microscale manipulation using evanescent Scholte waves.
Aubert V, Wunenburger R, Valier-Brasier T, Rabaud D, Kleman JP, Poulain C
Lab Chip 2016 Jul 7;16:2532-9

Backbone 1H, 15N, 13C NMR assignment of the 518-627 fragment of the androgen receptor encompassing N-terminal and DNA binding domains.
Meyer S, Wang YH, Pérez-Escrivà P, Kieffer B
Biomol NMR Assign 2016 Apr;10:175-8

Binding of RNA by the Nucleoproteins of Influenza Viruses A and B.
Labaronne A, Swale C, Monod A, Schoehn G, Crépin T, Ruigrok RW
Viruses 2016 Sep 13;8:

BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation.
Stupfler B, Birck C, Séraphin B, Mauxion F
Nat Commun 2016 Feb 25;7:10811

Carbon-sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE.
Rohac R, Amara P, Benjdia A, Martin L, Ruffié P, Favier A, Berteau O, Mouesca JM, Fontecilla-Camps JC, Nicolet Y
Nat Chem 2016 May;8:491-500

Carborane-based design of a potent vitamin D receptor agonist.
Otero R, Seoane S, Sigüeiro R, Belorusova AY, Maestro MA, Pérez-Fernández R, Rochel N, Mouriño A
Chem Sci 2016 Feb 1;7:1033-1037

CD4-mimetic sulfopeptide conjugates display sub-nanomolar anti-HIV-1 activity and protect macaques against a SHIV162P3 vaginal challenge.
Ariën KK, Baleux F, Desjardins D, Porrot F, Coïc YM, Michiels J, Bouchemal K, Bonnaffé D, Bruel T, Schwartz O, Le Grand R, Vanham G, Dereuddre-Bosquet N, Lortat-Jacob H
Sci Rep 2016 Oct 10;6:34829

ClusterViSu, a method for clustering of protein complexes by Voronoi tessellation in super-resolution microscopy.
Andronov L, Orlov I, Lutz Y, Vonesch JL, Klaholz BP
Sci Rep 2016 Apr 12;6:24084

CO and CN- syntheses by [FeFe]-hydrogenase maturase HydG are catalytically differentiated events.
Pagnier A, Martin L, Zeppieri L, Nicolet Y, Fontecilla-Camps JC
Proc Natl Acad Sci U S A 2016 Jan 5;113:104-9

Controlling Light Harvesting with Light.
Gwizdala M, Berera R, Kirilovsky D, van Grondelle R, Krüger TP
J Am Chem Soc 2016 Sep 14;138:11616-22

Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.
Voisinne G, García-Blesa A, Chaoui K, Fiore F, Bergot E, Girard L, Malissen M, Burlet-Schiltz O, Gonzalez de Peredo A, Malissen B, Roncagalli R
Mol Syst Biol 2016 Jul 29;12:876

Covalent Tethering and Residues with Bulky Hydrophobic Side Chains Enable Self-Assembly of Distinct Amyloid Structures.
Ruiz J, Boehringer R, Grogg M, Raya J, Schirer A, Crucifix C, Hellwig P, Schultz P, Torbeev V
Chembiochem 2016 Dec 2;17:2274-2285

Cross-Correlated Relaxation of Dipolar Coupling and Chemical-Shift Anisotropy in Magic-Angle Spinning R1ρ NMR Measurements: Application to Protein Backbone Dynamics Measurements.
Kurauskas V, Weber E, Hessel A, Ayala I, Marion D, Schanda P
J Phys Chem B 2016 Sep 1;120:8905-13

Cryo-electron Microscopy Structure of the Native Prototype Foamy Virus Glycoprotein and Virus Architecture.
Effantin G, Estrozi LF, Aschman N, Renesto P, Stanke N, Lindemann D, Schoehn G, Weissenhorn W
PLoS Pathog 2016 Jul;12:e1005721

Cryo-EM study of start codon selection during archaeal translation initiation.
Coureux PD, Lazennec-Schurdevin C, Monestier A, Larquet E, Cladière L, Klaholz BP, Schmitt E, Mechulam Y
Nat Commun 2016 Nov 7;7:13366

Crystallographic Study of Peptidoglycan Biosynthesis Enzyme MurD: Domain Movement Revisited.
Šink R, Kotnik M, Zega A, Barreteau H, Gobec S, Blanot D, Dessen A, Contreras-Martel C
PLoS One 2016 ;11:e0152075

Crystal Structures of Quinolinate Synthase in Complex with a Substrate Analogue, the Condensation Intermediate, and Substrate-Derived Product.
Volbeda A, Darnault C, Renoux O, Reichmann D, Amara P, Ollagnier de Choudens S, Fontecilla-Camps JC
J Am Chem Soc 2016 Sep 14;138:11802-9

Cytoplasmic proliferating cell nuclear antigen connects glycolysis and cell survival in acute myeloid leukemia.
Ohayon D, De Chiara A, Chapuis N, Candalh C, Mocek J, Ribeil JA, Haddaoui L, Ifrah N, Hermine O, Bouillaud F, Frachet P, Bouscary D, Witko-Sarsat V
Sci Rep 2016 Oct 19;6:35561

Destabilizing an interacting motif strengthens the association of a designed ankyrin repeat protein with tubulin.
Ahmad S, Pecqueur L, Dreier B, Hamdane D, Aumont-Nicaise M, Plückthun A, Knossow M, Gigant B
Sci Rep 2016 Jul 6;6:28922

DNA minicircles clarify the specific role of DNA structure on retroviral integration.
Pasi M, Mornico D, Volant S, Juchet A, Batisse J, Bouchier C, Parissi V, Ruff M, Lavery R, Lavigne M
Nucleic Acids Res 2016 Sep 19;44:7830-47

eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Simonetti A, Brito Querido J, Myasnikov AG, Mancera-Martinez E, Renaud A, Kuhn L, Hashem Y
Mol Cell 2016 Jul 21;63:206-217

Electron transfer activity of a de novo designed copper center in a three-helix bundle fold.
Plegaria JS, Herrero C, Quaranta A, Pecoraro VL
Biochim Biophys Acta 2016 May;1857:522-530

Enhancement of Ebola Virus Infection via Ficolin-1 Interaction with the Mucin Domain of GP Glycoprotein.
Favier AL, Gout E, Reynard O, Ferraris O, Kleman JP, Volchkov V, Peyrefitte C, Thielens NM
J Virol 2016 Jun 1;90:5256-5269

Ensemble Structure of the Highly Flexible Complex Formed between Vesicular Stomatitis Virus Unassembled Nucleoprotein and its Phosphoprotein Chaperone.
Yabukarski F, Leyrat C, Martinez N, Communie G, Ivanov I, Ribeiro EA Jr, Buisson M, Gerard FC, Bourhis JM, Jensen MR, Bernadó P, Blackledge M, Jamin M
J Mol Biol 2016 Jul 3;428:2671-94

Enterococcus hirae LcpA (Psr), a new peptidoglycan-binding protein localized at the division site.
Maréchal M, Amoroso A, Morlot C, Vernet T, Coyette J, Joris B
BMC Microbiol 2016 Oct 12;16:239

Epithelial Splicing Regulatory Protein 1 (ESRP1) is a new regulator of stomach smooth muscle development and plasticity.
Sagnol S, Marchal S, Yang Y, Allemand F, de Santa Barbara P
Dev Biol 2016 Jun 15;414:207-18

Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.
Raux B, Voitovich Y, Derviaux C, Lugari A, Rebuffet E, Milhas S, Priet S, Roux T, Trinquet E, Guillemot JC, Knapp S, Brunel JM, Fedorov AY, Collette Y, Roche P, Betzi S, Combes S, Morelli X
J Med Chem 2016 Feb 25;59:1634-41

Fine-tuning of a radical-based reaction by radical S-adenosyl-L-methionine tryptophan lyase.
Sicoli G, Mouesca JM, Zeppieri L, Amara P, Martin L, Barra AL, Fontecilla-Camps JC, Gambarelli S, Nicolet Y
Science 2016 Mar 18;351:1320-3

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities.
Ahmed-Belkacem A, Colliandre L, Ahnou N, Nevers Q, Gelin M, Bessin Y, Brillet R, Cala O, Douguet D, Bourguet W, Krimm I, Pawlotsky JM, Guichou JF
Nat Commun 2016 Sep 22;7:12777

Functional and structural characterization of two Bacillus megaterium nitroreductases biotransforming the herbicide mesotrione.
Carles L, Besse-Hoggan P, Joly M, Vigouroux A, Moréra S, Batisson I
Biochem J 2016 May 15;473:1443-53

Fusion to a homo-oligomeric scaffold allows cryo-EM analysis of a small protein.
Coscia F, Estrozi LF, Hans F, Malet H, Noirclerc-Savoye M, Schoehn G, Petosa C
Sci Rep 2016 Aug 3;6:30909

Gbp2 interacts with THO/TREX through a novel type of RRM domain.
Martínez-Lumbreras S, Taverniti V, Zorrilla S, Séraphin B, Pérez-Cañadillas JM
Nucleic Acids Res 2016 Jan 8;44:437-48

Heparan sulfate differentially controls CXCL12α- and CXCL12γ-mediated cell migration through differential presentation to their receptor CXCR4.
Connell BJ, Sadir R, Baleux F, Laguri C, Kleman JP, Luo L, Arenzana-Seisdedos F, Lortat-Jacob H
Sci Signal 2016 Nov 1;9:ra107

Highly Sensitive Coherent Anti-Stokes Raman Scattering Imaging of Protein Crystals.
Arzumanyan GM, Doroshkevich NV, Mamatkulov KZ, Shashkov SN, Zinovev EV, Vlasov AV, Round ES, Gordeliy VI
J Am Chem Soc 2016 Oct 19;138:13457-13460

High-Resolution Mapping of a Repeat Protein Folding Free Energy Landscape.
Fossat MJ, Dao TP, Jenkins K, Dellarole M, Yang Y, McCallum SA, Garcia AE, Barrick D, Roumestand C, Royer CA
Biophys J 2016 Dec 6;111:2368-2376

High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP-oleic acid complex: study of the internal water cluster and ligand binding by a transferred multipolar electron-density distribution.
Howard EI, Guillot B, Blakeley MP, Haertlein M, Moulin M, Mitschler A, Cousido-Siah A, Fadel F, Valsecchi WM, Tomizaki T, Petrova T, Claudot J, Podjarny A
IUCrJ 2016 Mar 1;3:115-26

How Quorum Sensing Connects Sporulation to Necrotrophism in Bacillus thuringiensis.
Perchat S, Talagas A, Poncet S, Lazar N, Li de la Sierra-Gallay I, Gohar M, Lereclus D, Nessler S
PLoS Pathog 2016 Aug;12:e1005779

IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors.
Cousido-Siah A, Ruiz FX, Fanfrlík J, Giménez-Dejoz J, Mitschler A, Kamlar M, Veselý J, Ajani H, Parés X, Farrés J, Hobza P, Podjarny AD
ACS Chem Biol 2016 Oct 21;11:2693-2705

Identification of Dynamic Modes in an Intrinsically Disordered Protein Using Temperature-Dependent NMR Relaxation.
Abyzov A, Salvi N, Schneider R, Maurin D, Ruigrok RW, Jensen MR, Blackledge M
J Am Chem Soc 2016 May 18;138:6240-51

Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels.
Lepage ML, Schneider JP, Bodlenner A, Meli A, De Riccardis F, Schmitt M, Tarnus C, Nguyen-Huynh NT, Francois YN, Leize-Wagner E, Birck C, Cousido-Siah A, Podjarny A, Izzo I, Compain P
Chemistry 2016 Apr 4;22:5151-5

Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses.
Yee AW, Moulin M, Breteau N, Haertlein M, Mitchell EP, Cooper JB, Boeri Erba E, Forsyth VT
Angew Chem Int Ed Engl 2016 Aug 1;55:9292-6

InterEvDock: a docking server to predict the structure of protein-protein interactions using evolutionary information.
Yu J, Vavrusa M, Andreani J, Rey J, Tufféry P, Guerois R
Nucleic Acids Res 2016 Jul 8;44:W542-9

Interplay between transglutaminases and heparan sulphate in progressive renal scarring.
Burhan I, Furini G, Lortat-Jacob H, Atobatele AG, Scarpellini A, Schroeder N, Atkinson J, Maamra M, Nutter FH, Watson P, Vinciguerra M, Johnson TS, Verderio EA
Sci Rep 2016 Oct 3;6:31343

Mask-based approach to phasing of single-particle diffraction data.
Lunin VY, Lunina NL, Petrova TE, Baumstark MW, Urzhumtsev AG
Acta Crystallogr D Struct Biol 2016 Jan;72:147-57

Metal homeostasis disruption and mitochondrial dysfunction in hepatocytes exposed to sub-toxic doses of zinc oxide nanoparticles.
Chevallet M, Gallet B, Fuchs A, Jouneau PH, Um K, Mintz E, Michaud-Soret I
Nanoscale 2016 Nov 3;8:18495-18506

MIB-MIP is a mycoplasma system that captures and cleaves immunoglobulin G.
Arfi Y, Minder L, Di Primo C, Le Roy A, Ebel C, Coquet L, Claverol S, Vashee S, Jores J, Blanchard A, Sirand-Pugnet P
Proc Natl Acad Sci U S A 2016 May 10;113:5406-11

Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.
Latrick CM, Marek M, Ouararhni K, Papin C, Stoll I, Ignatyeva M, Obri A, Ennifar E, Dimitrov S, Romier C, Hamiche A
Nat Struct Mol Biol 2016 Apr;23:309-16

Monitoring of the retinoic acid receptor-retinoid X receptor dimerization upon DNA binding by native mass spectrometry.
Nguyen-Huynh NT, Osz J, Peluso-Iltis C, Rochel N, Potier N, Leize-Wagner E
Biophys Chem 2016 Mar;210:2-8

Multi-Timescale Dynamics in Intrinsically Disordered Proteins from NMR Relaxation and Molecular Simulation.
Salvi N, Abyzov A, Blackledge M
J Phys Chem Lett 2016 Jul 7;7:2483-9

Mycobacterium tuberculosis LppM Displays an Original Structure and Domain Composition Linked to a Dual Localization.
Barthe P, Veyron-Churlet R, de Visch A, Gilleron M, Saliou JM, Tomavo S, Nigou J, Brodin P, Cohen-Gonsaud M
Structure 2016 Oct 4;24:1788-1794

New IKK inhibitors: Synthesis of new imidazo[1,2-a]quinoxaline derivatives using microwave assistance and biological evaluation as IKK inhibitors.
Moarbess G, Guichou JF, Paniagua-Gayraud S, Chouchou A, Marcadet O, Leroy F, Ruédas R, Cuq P, Deleuze-Masquéfa C, Bonnet PA
Eur J Med Chem 2016 Jun 10;115:268-74

New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships.
Zghaib Z, Guichou JF, Vappiani J, Bec N, Hadj-Kaddour K, Vincent LA, Paniagua-Gayraud S, Larroque C, Moarbess G, Cuq P, Kassab I, Deleuze-Masquéfa C, Diab-Assaf M, Bonnet PA
Bioorg Med Chem 2016 Jun 1;24:2433-40

New insight into the structural, electrochemical and biological aspects of macroacyclic Cu(II) complexes derived from S-substituted dithiocarbazate schiff bases.
Low ML, Maigre L, Tahir MI, Tiekink ER, Dorlet P, Guillot R, Ravoof TB, Rosli R, Pagès JM, Policar C, Delsuc N, Crouse KA
Eur J Med Chem 2016 Sep 14;120:1-12

New insights into the mechanism of substrates trafficking in Glyoxylate/Hydroxypyruvate reductases.
Lassalle L, Engilberge S, Madern D, Vauclare P, Franzetti B, Girard E
Sci Rep 2016 Feb 11;6:20629

NMR WaterLOGSY Reveals Weak Binding of Bisphenol A with Amyloid Fibers of a Conserved 11 Residue Peptide from Androgen Receptor.
Asencio-Hernández J, Kieffer B, Delsuc MA
PLoS One 2016 ;11:e0161948

Nonhydrolyzable C-disaccharides, a new class of DC-SIGN ligands.
Bertolotti B, Oroszová B, Sutkeviciute I, Kniežo L, Fieschi F, Parkan K, Lovyová Z, Kašáková M, Moravcová J
Carbohydr Res 2016 Nov 29;435:7-18

Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication.
Lahaye X, Satoh T, Gentili M, Cerboni S, Silvin A, Conrad C, Ahmed-Belkacem A, Rodriguez EC, Guichou JF, Bosquet N, Piel M, Le Grand R, King MC, Pawlotsky JM, Manel N
Cell Rep 2016 Apr 26;15:879-892

On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport.
Montigny C, Lyons J, Champeil P, Nissen P, Lenoir G
Biochim Biophys Acta 2016 Aug;1861:767-783

Oxygen activation in NO synthases: evidence for a direct role of the substrate.
Brunel A, Lang J, Couture M, Boucher JL, Dorlet P, Santolini J
FEBS Open Bio 2016 May;6:386-97

PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF.
Tadi SK, Tellier-Lebègue C, Nemoz C, Drevet P, Audebert S, Roy S, Meek K, Charbonnier JB, Modesti M
Cell Rep 2016 Oct 4;17:541-555

Photoreduction of the ferredoxin/ferredoxin-NADP(+)-reductase complex by a linked ruthenium polypyridyl chromophore.
Quaranta A, Lagoutte B, Frey J, Sétif P
J Photochem Photobiol B 2016 Jul;160:347-54

Pigment structure in the FCP-like light-harvesting complex from Chromera velia.
Llansola-Portoles MJ, Uragami C, Pascal AA, Bina D, Litvin R, Robert B
Biochim Biophys Acta 2016 Nov;1857:1759-1765

Priming and polymerization of a bacterial contractile tail structure.
Zoued A, Durand E, Brunet YR, Spinelli S, Douzi B, Guzzo M, Flaugnatti N, Legrand P, Journet L, Fronzes R, Mignot T, Cambillau C, Cascales E
Nature 2016 Mar 3;531:59-63

Principal Component Analysis of Lipid Molecule Conformational Changes in Molecular Dynamics Simulations.
Buslaev P, Gordeliy V, Grudinin S, Gushchin I
J Chem Theory Comput 2016 Mar 8;12:1019-28

Probing the pigment binding sites in LHCII with resonance Raman spectroscopy: The effect of mutations at S123.
Kish E, Wang K, Llansola-Portoles MJ, Ilioaia C, Pascal AA, Robert B, Yang C
Biochim Biophys Acta 2016 Sep;1857:1490-1496

Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5.
Timucin E, Cousido-Siah A, Mitschler A, Podjarny A, Sezerman OU
Proteins 2016 Jan;84:129-42

Production of unstable proteins through the formation of stable core complexes.
Levy N, Eiler S, Pradeau-Aubreton K, Maillot B, Stricher F, Ruff M
Nat Commun 2016 Mar 17;7:10932

Rational design of ultrastable and reversibly photoswitchable fluorescent proteins for super-resolution imaging of the bacterial periplasm.
El Khatib M, Martins A, Bourgeois D, Colletier JP, Adam V
Sci Rep 2016 Jan 6;6:18459

Reaction of PerR with Molecular Oxygen May Assist H2O2 Sensing in Anaerobes.
Sethu R, Gouré E, Signor L, Caux-Thang C, Clémancey M, Duarte V, Latour JM
ACS Chem Biol 2016 May 20;11:1438-44

Recombinant expression of the precursor of the hemorrhagic metalloproteinase HF3 and its non-catalytic domains using a cell-free synthesis system.
Menezes MC, Imbert L, Kitano ES, Vernet T, Serrano SM
Amino Acids 2016 Sep;48:2205-14

Redox Control of the Human Iron-Sulfur Repair Protein MitoNEET Activity via Its Iron-Sulfur Cluster.
Golinelli-Cohen MP, Lescop E, Mons C, Gonçalves S, Clémancey M, Santolini J, Guittet E, Blondin G, Latour JM, Bouton C
J Biol Chem 2016 Apr 1;291:7583-93

Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation.
Martin F, Ménétret JF, Simonetti A, Myasnikov AG, Vicens Q, Prongidi-Fix L, Natchiar SK, Klaholz BP, Eriani G
Nat Commun 2016 Aug 24;7:12622

RIDME spectroscopy on high-spin Mn2+ centers.
Akhmetzyanov D, Ching HY, Denysenkov V, Demay-Drouhard P, Bertrand HC, Tabares LC, Policar C, Prisner TF, Un S
Phys Chem Chem Phys 2016 Nov 9;18:30857-30866

SAXS/SANS on Supercharged Proteins Reveals Residue-Specific Modifications of the Hydration Shell.
Kim HS, Martel A, Girard E, Moulin M, Härtlein M, Madern D, Blackledge M, Franzetti B, Gabel F
Biophys J 2016 May 24;110:2185-94

Secondary Structure Prediction of Protein Constructs Using Random Incremental Truncation and Vacuum-Ultraviolet CD Spectroscopy.
Pukáncsik M, Orbán Á, Nagy K, Matsuo K, Gekko K, Maurin D, Hart D, Kézsmárki I, Vertessy BG
PLoS One 2016 ;11:e0156238

Self-Assembly of Measles Virus Nucleocapsid-like Particles: Kinetics and RNA Sequence Dependence.
Milles S, Jensen MR, Communie G, Maurin D, Schoehn G, Ruigrok RW, Blackledge M
Angew Chem Int Ed Engl 2016 Aug 1;55:9356-60

Sensitive proton-detected solid-state NMR spectroscopy of large proteins with selective CH3 labelling: application to the 50S ribosome subunit.
Kurauskas V, Crublet E, Macek P, Kerfah R, Gauto DF, Boisbouvier J, Schanda P
Chem Commun (Camb) 2016 Jul 21;52:9558-61

SharpViSu: integrated analysis and segmentation of super-resolution microscopy data.
Andronov L, Lutz Y, Vonesch JL, Klaholz BP
Bioinformatics 2016 Jul 15;32:2239-41

Solution Behavior of Amphiphilic Glycodendrimers with a Rod-Like Core.
Ordanini S, Zanchetta G, Porkolab V, Ebel C, Fieschi F, Guzzetti I, Potenza D, Palmioli A, Podlipnik Č, Meroni D, Bernardi A
Macromol Biosci 2016 Jun;16:896-905

Solution Behavior of the Intrinsically Disordered N-Terminal Domain of Retinoid X Receptor α in the Context of the Full-Length Protein.
Belorusova A, Osz J, Petoukhov MV, Peluso-Iltis C, Kieffer B, Svergun DI, Rochel N
Biochemistry 2016 Mar 29;55:1741-1748

Solution structure of the 5'-terminal hairpin of the 7SK small nuclear RNA.
Bourbigot S, Dock-Bregeon AC, Eberling P, Coutant J, Kieffer B, Lebars I
RNA 2016 Dec;22:1844-1858

Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase.
Bourne Y, Sharpless KB, Taylor P, Marchot P
J Am Chem Soc 2016 Feb 10;138:1611-21

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Uchikawa E, Lethier M, Malet H, Brunel J, Gerlier D, Cusack S
Mol Cell 2016 May 19;62:586-602

Structural and dynamics studies of a truncated variant of CI repressor from bacteriophage TP901-1.
Rasmussen KK, Frandsen KE, Boeri Erba E, Pedersen M, Varming AK, Hammer K, Kilstrup M, Thulstrup PW, Blackledge M, Jensen MR, Lo Leggio L
Sci Rep 2016 Jul 12;6:29574

Structural and Functional Characterization of a Single-Chain Form of the Recognition Domain of Complement Protein C1q.
Moreau C, Bally I, Chouquet A, Bottazzi B, Ghebrehiwet B, Gaboriaud C, Thielens N
Front Immunol 2016 ;7:79

Structural and Functional Investigation of the Ag(+)/Cu(+) Binding Domains of the Periplasmic Adaptor Protein SilB from Cupriavidus metallidurans CH34.
Urbina P, Bersch B, De Angelis F, Derfoufi KM, Prévost M, Goormaghtigh E, Vandenbussche G
Biochemistry 2016 May 24;55:2883-97

Structural Basis for High Specificity of Amadori Compound and Mannopine Opine Binding in Bacterial Pathogens.
Marty L, Vigouroux A, Aumont-Nicaise M, Dessaux Y, Faure D, Moréra S
J Biol Chem 2016 Oct 21;291:22638-22649

Structural Basis of Lipid Targeting and Destruction by the Type V Secretion System of Pseudomonas aeruginosa.
da Mata Madeira PV, Zouhir S, Basso P, Neves D, Laubier A, Salacha R, Bleves S, Faudry E, Contreras-Martel C, Dessen A
J Mol Biol 2016 May 8;428:1790-803

Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5.
Swale C, Monod A, Tengo L, Labaronne A, Garzoni F, Bourhis JM, Cusack S, Schoehn G, Berger I, Ruigrok RW, Crépin T
Sci Rep 2016 Apr 20;6:24727

Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering.
Papageorgiou N, Lichière J, Baklouti A, Ferron F, Sévajol M, Canard B, Coutard B
Acta Crystallogr D Struct Biol 2016 Feb;72:192-202

Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA.
Redrejo-Rodríguez M, Vigouroux A, Mursalimov A, Grin I, Alili D, Koshenov Z, Akishev Z, Maksimenko A, Bissenbaev AK, Matkarimov BT, Saparbaev M, Ishchenko AA, Moréra S
Biochimie 2016 Sep-Oct;128-129:20-33

Structural evidence for Nap1-dependent H2A-H2B deposition and nucleosome assembly.
Aguilar-Gurrieri C, Larabi A, Vinayachandran V, Patel NA, Yen K, Reja R, Ebong IO, Schoehn G, Robinson CV, Pugh BF, Panne D
EMBO J 2016 Jul 1;35:1465-82

Structural insights into the Escherichia coli lysine decarboxylases and molecular determinants of interaction with the AAA+ ATPase RavA.
Kandiah E, Carriel D, Perard J, Malet H, Bacia M, Liu K, Chan SW, Houry WA, Ollagnier de Choudens S, Elsen S, Gutsche I
Sci Rep 2016 Apr 15;6:24601

Structural Studies of Vitamin D Nuclear Receptor Ligand-Binding Properties.
Belorusova AY, Rochel N
Vitam Horm 2016 ;100:83-116

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis.
Heimburg T, Chakrabarti A, Lancelot J, Marek M, Melesina J, Hauser AT, Shaik TB, Duclaud S, Robaa D, Erdmann F, Schmidt M, Romier C, Pierce RJ, Jung M, Sippl W
J Med Chem 2016 Mar 24;59:2423-35

Structure-function analysis of the extracellular domain of the pneumococcal cell division site positioning protein MapZ.
Manuse S, Jean NL, Guinot M, Lavergne JP, Laguri C, Bougault CM, VanNieuwenhze MS, Grangeasse C, Simorre JP
Nat Commun 2016 Jun 27;7:12071

Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Myasnikov AG, Kundhavai Natchiar S, Nebout M, Hazemann I, Imbert V, Khatter H, Peyron JF, Klaholz BP
Nat Commun 2016 Sep 26;7:12856

Structure of a truncated form of leucine zipper II of JIP3 reveals an unexpected antiparallel coiled-coil arrangement.
Llinas P, Chenon M, Nguyen TQ, Moreira C, de Régibus A, Coquard A, Ramos MJ, Guérois R, Fernandes PA, Ménétrey J
Acta Crystallogr F Struct Biol Commun 2016 Mar;72:198-206

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.
Martinez-Zapien D, Ruiz FX, Poirson J, Mitschler A, Ramirez J, Forster A, Cousido-Siah A, Masson M, Vande Pol S, Podjarny A, Travé G, Zanier K
Nature 2016 Jan 28;529:541-5

Structure of the host-recognition device of Staphylococcus aureus phage ϕ11.
Koç C, Xia G, Kühner P, Spinelli S, Roussel A, Cambillau C, Stehle T
Sci Rep 2016 Jun 10;6:27581

Structure of the initiation-competent RNA polymerase I and its implication for transcription.
Pilsl M, Crucifix C, Papai G, Krupp F, Steinbauer R, Griesenbeck J, Milkereit P, Tschochner H, Schultz P
Nat Commun 2016 Jul 15;7:12126

Structure of the light-driven sodium pump KR2 and its implications for optogenetics.
Gushchin I, Shevchenko V, Polovinkin V, Borshchevskiy V, Buslaev P, Bamberg E, Gordeliy V
FEBS J 2016 Apr;283:1232-8

Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties.
Moreau C, Cioci G, Iannello M, Laffly E, Chouquet A, Ferreira A, Thielens NM, Gaboriaud C
IUCrJ 2016 Nov 1;3:408-419

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors.
Senger J, Melesina J, Marek M, Romier C, Oehme I, Witt O, Sippl W, Jung M
J Med Chem 2016 Feb 25;59:1545-55

The Atomic Structure of the Phage Tuc2009 Baseplate Tripod Suggests that Host Recognition Involves Two Different Carbohydrate Binding Modules.
Legrand P, Collins B, Blangy S, Murphy J, Spinelli S, Gutierrez C, Richet N, Kellenberger C, Desmyter A, Mahony J, van Sinderen D, Cambillau C
MBio 2016 Jan 26;7:e01781-15

The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation.
Schulte T, Mikaelsson C, Beaussart A, Kikhney A, Deshmukh M, Wolniak S, Pathak A, Ebel C, Löfling J, Fogolari F, Henriques-Normark B, Dufrêne YF, Svergun D, Nygren PÅ, Achour A
Sci Rep 2016 Sep 1;6:32371

The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity.
Roulland Y, Ouararhni K, Naidenov M, Ramos L, Shuaib M, Syed SH, Lone IN, Boopathi R, Fontaine E, Papai G, Tachiwana H, Gautier T, Skoufias D, Padmanabhan K, Bednar J, Kurumizaka H, Schultz P, Angelov D, Hamiche A, Dimitrov S
Mol Cell 2016 Aug 18;63:674-685

The N-terminal domain plays a crucial role in the structure of a full-length human mitochondrial Lon protease.
Kereïche S, Kováčik L, Bednár J, Pevala V, Kunová N, Ondrovičová G, Bauer J, Ambro Ľ, Bellová J, Kutejová E, Raška I
Sci Rep 2016 Sep 16;6:33631

The Quaternary Structure of a Glycoside Hydrolase Dictates Specificity toward β-Glucans.
Lafond M, Sulzenbacher G, Freyd T, Henrissat B, Berrin JG, Garron ML
J Biol Chem 2016 Mar 25;291:7183-94

The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase.
Valsecchi WM, Cousido-Siah A, Defelipe LA, Mitschler A, Podjarny A, Santos J, Delfino JM
Biochim Biophys Acta 2016 Jun;1864:655-666

The Use of Mn(II) Bound to His-tags as Genetically Encodable Spin-Label for Nanometric Distance Determination in Proteins.
Ching HY, Mascali FC, Bertrand HC, Bruch EM, Demay-Drouhard P, Rasia RM, Policar C, Tabares LC, Un S
J Phys Chem Lett 2016 Mar 17;7:1072-6

Using Genetically Encodable Self-Assembling Gd(III) Spin Labels To Make In-Cell Nanometric Distance Measurements.
Mascali FC, Ching HY, Rasia RM, Un S, Tabares LC
Angew Chem Int Ed Engl 2016 Sep 5;55:11041-3

Visualization, quantification and coordination of Ag+ ions released from silver nanoparticles in hepatocytes.
Veronesi G, Deniaud A, Gallon T, Jouneau PH, Villanova J, Delangle P, Carrière M, Kieffer I, Charbonnier P, Mintz E, Michaud-Soret I
Nanoscale 2016 Sep 29;8:17012-17021

Volume of Hsp90 Protein-Ligand Binding Determined by Fluorescent Pressure Shift Assay, Densitometry, and NMR.
Toleikis Z, Sirotkin VA, Skvarnavičius G, Smirnovienė J, Roumestand C, Matulis D, Petrauskas V
J Phys Chem B 2016 Sep 22;120:9903-12

X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain.
Fadel F, Zhao Y, Cousido-Siah A, Ruiz FX, Mitschler A, Podjarny A
PLoS One 2016 ;11:e0154190

2015 publications

(1)H, (15)N and (13)C backbone resonance assignments of murine met-neuroglobin, free and in complex with cyanide.
Yang Y, Allemand F, Guca E, Vallone B, Delbecq S, Roumestand C
Biomol NMR Assign 2015 Apr;9:153-6

9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice.
Rühl R, Krzyżosiak A, Niewiadomska-Cimicka A, Rochel N, Szeles L, Vaz B, Wietrzych-Schindler M, Álvarez S, Szklenar M, Nagy L, de Lera AR, Krężel W
PLoS Genet 2015 Jun;11:e1005213

Accurate DOSY measure for out-of-equilibrium systems using permutated DOSY (p-DOSY).
Oikonomou M, Asencio-Hernández J, Velders AH, Delsuc MA
J Magn Reson 2015 Sep;258:12-6

A dimeric chlorite dismutase exhibits O2-generating activity and acts as a chlorite antioxidant in Klebsiella pneumoniae MGH 78578.
Celis AI, Geeraerts Z, Ngmenterebo D, Machovina MM, Kurker RC, Rajakumar K, Ivancich A, Rodgers KR, Lukat-Rodgers GS, DuBois JL
Biochemistry 2015 Jan 20;54:434-46

A flexible extension of the Drosophila ultrabithorax homeodomain defines a novel Hox/PBC interaction mode.
Foos N, Maurel-Zaffran C, Maté MJ, Vincentelli R, Hainaut M, Berenger H, Pradel J, Saurin AJ, Ortiz-Lombardía M, Graba Y
Structure 2015 Feb 3;23:270-9

A major determinant for gliding motility in Mycoplasma genitalium: the interaction between the terminal organelle proteins MG200 and MG491.
Martinelli L, Lalli D, García-Morales L, Ratera M, Querol E, Piñol J, Fita I, Calisto BM
J Biol Chem 2015 Jan 16;290:1699-711

Analytical ultracentrifugation and preliminary X-ray studies of the chloroplast envelope quinone oxidoreductase homologue from Arabidopsis thaliana.
Mas y mas S, Giustini C, Ferrer JL, Rolland N, Curien G, Cobessi D
Acta Crystallogr F Struct Biol Commun 2015 Apr;71:455-8

An Approach to Heterologous Expression of Membrane Proteins. The Case of Bacteriorhodopsin.
Bratanov D, Balandin T, Round E, Shevchenko V, Gushchin I, Polovinkin V, Borshchevskiy V, Gordeliy V
PLoS One 2015 ;10:e0128390

A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation.
Deniaud A, Karuppasamy M, Bock T, Masiulis S, Huard K, Garzoni F, Kerschgens K, Hentze MW, Kulozik AE, Beck M, Neu-Yilik G, Schaffitzel C
Nucleic Acids Res 2015 Sep 3;43:7600-11

Antibody Binding Selectivity: Alternative Sets of Antigen Residues Entail High-Affinity Recognition.
Nominé Y, Choulier L, Travé G, Vernet T, Altschuh D
PLoS One 2015 ;10:e0143374

Assembly of oxygen-evolving Photosystem II efficiently occurs with the apo-Cytb559 but the holo-Cytb559 accelerates the recovery of a functional enzyme upon photoinhibition.
Sugiura M, Nakamura M, Koyama K, Boussac A
Biochim Biophys Acta 2015 Feb;1847:276-285

A structural snapshot of type II pilus formation in Streptococcus pneumoniae.
Shaik MM, Lombardi C, Maragno Trindade D, Fenel D, Schoehn G, Di Guilmi AM, Dessen A
J Biol Chem 2015 Sep 11;290:22581-92

Asymmetric ring structure of Vps4 required for ESCRT-III disassembly.
Caillat C, Macheboeuf P, Wu Y, McCarthy AA, Boeri-Erba E, Effantin G, Göttlinger HG, Weissenhorn W, Renesto P
Nat Commun 2015 Dec 3;6:8781

Atomic view of the histidine environment stabilizing higher-pH conformations of pH-dependent proteins.
Valéry C, Deville-Foillard S, Lefebvre C, Taberner N, Legrand P, Meneau F, Meriadec C, Delvaux C, Bizien T, Kasotakis E, Lopez-Iglesias C, Gall A, Bressanelli S, Le Du MH, Paternostre M, Artzner F
Nat Commun 2015 Jul 20;6:7771

A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.
Huet T, Laverny G, Ciesielski F, Molnár F, Ramamoorthy TG, Belorusova AY, Antony P, Potier N, Metzger D, Moras D, Rochel N
Cell Rep 2015 Feb 3;10:516-26

Bacteriophage SPP1 tail tube protein self-assembles into β-structure-rich tubes.
Langlois C, Ramboarina S, Cukkemane A, Auzat I, Chagot B, Gilquin B, Ignatiou A, Petitpas I, Kasotakis E, Paternostre M, White HE, Orlova EV, Baldus M, Tavares P, Zinn-Justin S
J Biol Chem 2015 Feb 6;290:3836-49

Biogenesis and structure of a type VI secretion membrane core complex.
Durand E, Nguyen VS, Zoued A, Logger L, Péhau-Arnaudet G, Aschtgen MS, Spinelli S, Desmyter A, Bardiaux B, Dujeancourt A, Roussel A, Cambillau C, Cascales E, Fronzes R
Nature 2015 Jul 30;523:555-60

Biophysical and physiological characterization of ZraP from Escherichia coli, the periplasmic accessory protein of the atypical ZraSR two-component system.
Petit-Härtlein I, Rome K, de Rosny E, Molton F, Duboc C, Gueguen E, Rodrigue A, Covès J
Biochem J 2015 Dec 1;472:205-16

C5-epimerase and 2-O-sulfotransferase associate in vitro to generate contiguous epimerized and 2-O-sulfated heparan sulfate domains.
Préchoux A, Halimi C, Simorre JP, Lortat-Jacob H, Laguri C
ACS Chem Biol 2015 Apr 17;10:1064-71

CH3-specific NMR assignment of alanine, isoleucine, leucine and valine methyl groups in high molecular weight proteins using a single sample.
Kerfah R, Hamelin O, Boisbouvier J, Marion D
J Biomol NMR 2015 Dec;63:389-402

Characterization and production of protein complexes by co-expression in Escherichia coli.
Haffke M, Marek M, Pelosse M, Diebold ML, Schlattner U, Berger I, Romier C
Methods Mol Biol 2015 ;1261:63-89

Chemical cross-linking and mass spectrometry to determine the subunit interaction network in a recombinant human SAGA HAT subcomplex.
Nguyen-Huynh NT, Sharov G, Potel C, Fichter P, Trowitzsch S, Berger I, Lamour V, Schultz P, Potier N, Leize-Wagner E
Protein Sci 2015 Aug;24:1232-46

Combining a NHS ester and glutaraldehyde improves crosslinking prior to MALDI MS analysis of intact protein complexes.
Boeri Erba E, Klein PA, Signor L
J Mass Spectrom 2015 Oct;50:1114-9

Conformational switching in a light-harvesting protein as followed by single-molecule spectroscopy.
Gall A, Ilioaia C, Krüger TP, Novoderezhkin VI, Robert B, van Grondelle R
Biophys J 2015 Jun 2;108:2713-20

Conformation transitions of eukaryotic polyribosomes during multi-round translation.
Afonina ZA, Myasnikov AG, Shirokov VA, Klaholz BP, Spirin AS
Nucleic Acids Res 2015 Jan;43:618-28

Crystallization of mutants of Turnip yellow mosaic virus protease/ubiquitin hydrolase designed to prevent protease self-recognition.
Ayach M, Bressanelli S
Acta Crystallogr F Struct Biol Commun 2015 Apr;71:405-8

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation.
Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H
Acta Crystallogr D Biol Crystallogr 2015 Sep;71:1890-9

Crystal structure of a light-driven sodium pump.
Gushchin I, Shevchenko V, Polovinkin V, Kovalev K, Alekseev A, Round E, Borshchevskiy V, Balandin T, Popov A, Gensch T, Fahlke C, Bamann C, Willbold D, Büldt G, Bamberg E, Gordeliy V
Nat Struct Mol Biol 2015 May;22:390-5

Crystal structure of HydG from Carboxydothermus hydrogenoformans: a trifunctional [FeFe]-hydrogenase maturase.
Nicolet Y, Pagnier A, Zeppieri L, Martin L, Amara P, Fontecilla-Camps JC
Chembiochem 2015 Feb 9;16:397-402

Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex.
Zhang W, Collinet B, Graille M, Daugeron MC, Lazar N, Libri D, Durand D, van Tilbeurgh H
Nucleic Acids Res 2015 Mar 31;43:3358-72

Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules.
Trowitzsch S, Viola C, Scheer E, Conic S, Chavant V, Fournier M, Papai G, Ebong IO, Schaffitzel C, Zou J, Haffke M, Rappsilber J, Robinson CV, Schultz P, Tora L, Berger I
Nat Commun 2015 Jan 14;6:6011

Definition and expression in E. coli of large fragments from the human lipid kinase phosphatidylinositol 4-kinase type III alpha, and purification of a 1100-residue N-terminal module.
Taveneau C, Blondeau K, Bressanelli S
Protein Expr Purif 2015 Oct;114:121-7

Dehydration affects the electronic structure of the primary electron donor in bacterial photosynthetic reaction centers: evidence from visible-NIR and light-induced difference FTIR spectroscopy.
Malferrari M, Turina P, Francia F, Mezzetti A, Leibl W, Venturoli G
Photochem Photobiol Sci 2015 Feb;14:238-51

Disorder-to-order transition of MAGI-1 PDZ1 C-terminal extension upon peptide binding: thermodynamic and dynamic insights.
Ramírez J, Recht R, Charbonnier S, Ennifar E, Atkinson RA, Travé G, Nominé Y, Kieffer B
Biochemistry 2015 Feb 17;54:1327-37

Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives.
Marek M, Oliveira G, Pierce RJ, Jung M, Sippl W, Romier C
Future Med Chem 2015 ;7:783-800

Echinenone vibrational properties: From solvents to the orange carotenoid protein.
Kish E, Pinto MM, Kirilovsky D, Spezia R, Robert B
Biochim Biophys Acta 2015 Oct;1847:1044-54

Electron transfer pathways from the S2-states to the S3-states either after a Ca2+/Sr2+ or a Cl-/I- exchange in Photosystem II from Thermosynechococcus elongatus.
Boussac A, Rutherford AW, Sugiura M
Biochim Biophys Acta 2015 Jun-Jul;1847:576-86

ESR - a retinal protein with unusual properties from Exiguobacterium sibiricum.
Petrovskaya LE, Balashov SP, Lukashev EP, Imasheva ES, Gushchin IY, Dioumaev AK, Rubin AB, Dolgikh DA, Gordeliy VI, Lanyi JK, Kirpichnikov MP
Biochemistry (Mosc) 2015 Jun;80:688-700

Evolutionarily Conserved Pattern of Interactions in a Protein Revealed by Local Thermal Expansion Properties.
Dellarole M, Caro JA, Roche J, Fossat M, Barthe P, García-Moreno E B, Royer CA, Roumestand C
J Am Chem Soc 2015 Jul 29;137:9354-62

FEM: feature-enhanced map.
Afonine PV, Moriarty NW, Mustyakimov M, Sobolev OV, Terwilliger TC, Turk D, Urzhumtsev A, Adams PD
Acta Crystallogr D Biol Crystallogr 2015 Mar;71:646-66

From deep TLS validation to ensembles of atomic models built from elemental motions.
Urzhumtsev A, Afonine PV, Van Benschoten AH, Fraser JS, Adams PD
Acta Crystallogr D Biol Crystallogr 2015 Aug;71:1668-83

FtsZ filament capping by MciZ, a developmental regulator of bacterial division.
Bisson-Filho AW, Discola KF, Castellen P, Blasios V, Martins A, Sforça ML, Garcia W, Zeri AC, Erickson HP, Dessen A, Gueiros-Filho FJ
Proc Natl Acad Sci U S A 2015 Apr 28;112:E2130-8

Functional insights from high resolution structures of mouse protein arginine methyltransferase 6.
Bonnefond L, Stojko J, Mailliot J, Troffer-Charlier N, Cura V, Wurtz JM, Cianférani S, Cavarelli J
J Struct Biol 2015 Aug;191:175-83

HDAC8: a multifaceted target for therapeutic interventions.
Chakrabarti A, Oehme I, Witt O, Oliveira G, Sippl W, Romier C, Pierce RJ, Jung M
Trends Pharmacol Sci 2015 Jul;36:481-92

Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors.
Melesina J, Robaa D, Pierce RJ, Romier C, Sippl W
J Mol Graph Model 2015 Nov;62:342-361

How Bonding in Manganous Phosphates Affects their Mn(II)-(31)P Hyperfine Interactions.
Un S, Bruch EM
Inorg Chem 2015 Nov 2;54:10422-8

Hydration water mobility is enhanced around tau amyloid fibers.
Fichou Y, Schirò G, Gallat FX, Laguri C, Moulin M, Combet J, Zamponi M, Härtlein M, Picart C, Mossou E, Lortat-Jacob H, Colletier JP, Tobias DJ, Weik M
Proc Natl Acad Sci U S A 2015 May 19;112:6365-70

Hydrolysis of clavulanate by Mycobacterium tuberculosis β-lactamase BlaC harboring a canonical SDN motif.
Soroka D, Li de la Sierra-Gallay I, Dubée V, Triboulet S, van Tilbeurgh H, Compain F, Ballell L, Barros D, Mainardi JL, Hugonnet JE, Arthur M
Antimicrob Agents Chemother 2015 Sep;59:5714-20

IBiSS, a versatile and interactive tool for integrated sequence and 3D structure analysis of large macromolecular complexes.
Beinsteiner B, Michalon J, Klaholz BP
Bioinformatics 2015 Oct 15;31:3339-44

In crystallo optical spectroscopy (icOS) as a complementary tool on the macromolecular crystallography beamlines of the ESRF.
von Stetten D, Giraud T, Carpentier P, Sever F, Terrien M, Dobias F, Juers DH, Flot D, Mueller-Dieckmann C, Leonard GA, de Sanctis D, Royant A
Acta Crystallogr D Biol Crystallogr 2015 Jan 1;71:15-26

Insights from a decade of biophysical studies on MutL: Roles in strand discrimination and mismatch removal.
Guarné A, Charbonnier JB
Prog Biophys Mol Biol 2015 Mar;117:149-56

INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate.
Moser von Filseck J, Čopič A, Delfosse V, Vanni S, Jackson CL, Bourguet W, Drin G
Science 2015 Jul 24;349:432-6

Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen.
Lopez J, Bittame A, Massera C, Vasseur V, Effantin G, Valat A, Buaillon C, Allart S, Fox BA, Rommereim LM, Bzik DJ, Schoehn G, Weissenhorn W, Dubremetz JF, Gagnon J, Mercier C, Cesbron-Delauw MF, Blanchard N
Cell Rep 2015 Dec 15;13:2273-86

Large-Scale Conformational Dynamics Control H5N1 Influenza Polymerase PB2 Binding to Importin α.
Delaforge E, Milles S, Bouvignies G, Bouvier D, Boivin S, Salvi N, Maurin D, Martel A, Round A, Lemke EA, Jensen MR, Hart DJ, Blackledge M
J Am Chem Soc 2015 Dec 9;137:15122-34

Live cell immunogold labelling of RNA polymerase II.
Orlov I, Schertel A, Zuber G, Klaholz B, Drillien R, Weiss E, Schultz P, Spehner D
Sci Rep 2015 Feb 9;5:8324

Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α1(2)βγδ nAChRs.
Bourne Y, Sulzenbacher G, Radić Z, Aráoz R, Reynaud M, Benoit E, Zakarian A, Servent D, Molgó J, Taylor P, Marchot P
Structure 2015 Jun 2;23:1106-15

Mechanism of β-lactam action in Streptococcus pneumoniae: the piperacillin paradox.
Philippe J, Gallet B, Morlot C, Denapaite D, Hakenbeck R, Chen Y, Vernet T, Zapun A
Antimicrob Agents Chemother 2015 Jan;59:609-21

Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists.
Chen KM, Campbell E, Pandey RR, Yang Z, McCarthy AA, Pillai RS
RNA 2015 May;21:833-9

Micellar and biochemical properties of a propyl-ended fluorinated surfactant designed for membrane-protein study.
Abla M, Unger S, Keller S, Bonneté F, Ebel C, Pucci B, Breyton C, Durand G
J Colloid Interface Sci 2015 May 1;445:127-36

Modeling the ComD/ComE/comcde interaction network using small angle X-ray scattering.
Sanchez D, Boudes M, van Tilbeurgh H, Durand D, Quevillon-Cheruel S
FEBS J 2015 Apr;282:1538-53

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.
Gaubitz C, Oliveira TM, Prouteau M, Leitner A, Karuppasamy M, Konstantinidou G, Rispal D, Eltschinger S, Robinson GC, Thore S, Aebersold R, Schaffitzel C, Loewith R
Mol Cell 2015 Jun 18;58:977-88

Nanometric distance measurements between Mn(ii)DOTA centers.
Vincent Ching HY, Demay-Drouhard P, Bertrand HC, Policar C, Tabares LC, Un S
Phys Chem Chem Phys 2015 Sep 28;17:23368-77

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM.
Fadel F, Zhao Y, Cachau R, Cousido-Siah A, Ruiz FX, Harlos K, Howard E, Mitschler A, Podjarny A
Acta Crystallogr D Biol Crystallogr 2015 Jul;71:1455-70

Novel insights into nickel import in Staphylococcus aureus: the positive role of free histidine and structural characterization of a new thiazolidine-type nickel chelator.
Lebrette H, Borezée-Durant E, Martin L, Richaud P, Boeri Erba E, Cavazza C
Metallomics 2015 Apr;7:613-21

Observing the overall rocking motion of a protein in a crystal.
Ma P, Xue Y, Coquelle N, Haller JD, Yuwen T, Ayala I, Mikhailovskii O, Willbold D, Colletier JP, Skrynnikov NR, Schanda P
Nat Commun 2015 Oct 5;6:8361

OrthoInspector 2.0: Software and database updates.
Linard B, Allot A, Schneider R, Morel C, Ripp R, Bigler M, Thompson JD, Poch O, Lecompte O
Bioinformatics 2015 Feb 1;31:447-8

Predicting X-ray diffuse scattering from translation-libration-screw structural ensembles.
Van Benschoten AH, Afonine PV, Terwilliger TC, Wall ME, Jackson CJ, Sauter NK, Adams PD, Urzhumtsev A, Fraser JS
Acta Crystallogr D Biol Crystallogr 2015 Aug;71:1657-67

Prioritizing targets for structural biology through the lens of proteomics: the archaeal protein TGAM_1934 from Thermococcus gammatolerans.
Yang YS, Fernandez B, Lagorce A, Aloin V, De Guillen KM, Boyer JB, Dedieu A, Confalonieri F, Armengaud J, Roumestand C
Proteomics 2015 Jan;15:114-23

Production and characterisation of Epstein-Barr virus helicase-primase complex and its accessory protein BBLF2/3.
Thierry E, Brennich M, Round A, Buisson M, Burmeister WP, Hutin S
Virus Genes 2015 Oct;51:171-81

Production, crystallization and X-ray diffraction analysis of a complex between a fragment of the TssM T6SS protein and a camelid nanobody.
Nguyen VS, Spinelli S, Desmyter A, Le TT, Kellenberger C, Cascales E, Cambillau C, Roussel A
Acta Crystallogr F Struct Biol Commun 2015 Mar;71:266-71

Profiling sulfation/epimerization pattern of full-length heparan sulfate by NMR following cell culture 13C-glucose metabolic labeling.
Pegeot M, Sadir R, Eriksson I, Kjellen L, Simorre JP, Gans P, Lortat-Jacob H
Glycobiology 2015 Feb;25:151-6

Programming new geometry restraints: parallelity of atomic groups.
Sobolev OV, Afonine PV, Adams PD, Urzhumtsev A
J Appl Crystallogr 2015 Aug 1;48:1130-1141

Protein Delivery System Containing a Nickel-Immobilized Polymer for Multimerization of Affinity-Purified His-Tagged Proteins Enhances Cytosolic Transfer.
Postupalenko V, Desplancq D, Orlov I, Arntz Y, Spehner D, Mely Y, Klaholz BP, Schultz P, Weiss E, Zuber G
Angew Chem Int Ed Engl 2015 Sep 1;54:10583-6

PscI is a type III secretion needle anchoring protein with in vitro polymerization capacities.
Monlezun L, Liebl D, Fenel D, Grandjean T, Berry A, Schoehn G, Dessein R, Faudry E, Attree I
Mol Microbiol 2015 Apr;96:419-36

Pulse Electron Double Resonance Detected Multinuclear NMR Spectra of Distant and Low Sensitivity Nuclei and Its Application to the Structure of Mn(II) Centers in Organisms.
Bruch EM, Warner MT, Thomine S, Tabares LC, Un S
J Phys Chem B 2015 Oct 29;119:13515-23

Remodeling of the Z-Ring Nanostructure during the Streptococcus pneumoniae Cell Cycle Revealed by Photoactivated Localization Microscopy.
Jacq M, Adam V, Bourgeois D, Moriscot C, Di Guilmi AM, Vernet T, Morlot C
MBio 2015 Aug 18;6:

Remote His50 Acts as a Coordination Switch in the High-Affinity N-Terminal Centered Copper(II) Site of α-Synuclein.
De Ricco R, Valensin D, Dell'Acqua S, Casella L, Dorlet P, Faller P, Hureau C
Inorg Chem 2015 May 18;54:4744-51

Resonance Raman spectra of carotenoid molecules: influence of methyl substitutions.
Macernis M, Galzerano D, Sulskus J, Kish E, Kim YH, Koo S, Valkunas L, Robert B
J Phys Chem A 2015 Jan 8;119:56-66

Schistosome sirtuins as drug targets.
Lancelot J, Cabezas-Cruz A, Caby S, Marek M, Schultz J, Romier C, Sippl W, Jung M, Pierce RJ
Future Med Chem 2015 ;7:765-82

Scrambling free combinatorial labeling of alanine-β, isoleucine-δ1, leucine-proS and valine-proS methyl groups for the detection of long range NOEs.
Kerfah R, Plevin MJ, Pessey O, Hamelin O, Gans P, Boisbouvier J
J Biomol NMR 2015 Jan;61:73-82

Self protein-protein interactions are involved in TPPP/p25 mediated microtubule bundling.
DeBonis S, Neumann E, Skoufias DA
Sci Rep 2015 Aug 20;5:13242

Spot peptide arrays and SPR measurements: throughput and quantification in antibody selectivity studies.
Vernet T, Choulier L, Nominé Y, Bellard L, Baltzinger M, Travé G, Altschuh D
J Mol Recognit 2015 Oct;28:635-44

Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10.
Cousido-Siah A, Ruiz FX, Crespo I, Porté S, Mitschler A, Parés X, Podjarny A, Farrés J
Chem Biol Interact 2015 Jun 5;234:290-6

Structural and biochemical characterization of the β-N-acetylglucosaminidase from Thermotoga maritima: toward rationalization of mechanistic knowledge in the GH73 family.
Lipski A, Hervé M, Lombard V, Nurizzo D, Mengin-Lecreulx D, Bourne Y, Vincent F
Glycobiology 2015 Mar;25:319-30

Structural and functional investigation of flavin binding center of the NqrC subunit of sodium-translocating NADH:quinone oxidoreductase from Vibrio harveyi.
Borshchevskiy V, Round E, Bertsova Y, Polovinkin V, Gushchin I, Ishchenko A, Kovalev K, Mishin A, Kachalova G, Popov A, Bogachev A, Gordeliy V
PLoS One 2015 ;10:e0118548

Structural basis of natural promoter recognition by the retinoid X nuclear receptor.
Osz J, McEwen AG, Poussin-Courmontagne P, Moutier E, Birck C, Davidson I, Moras D, Rochel N
Sci Rep 2015 Feb 3;5:8216

Structural characterization of metal binding to a cold-adapted frataxin.
Noguera ME, Roman EA, Rigal JB, Cousido-Siah A, Mitschler A, Podjarny A, Santos J
J Biol Inorg Chem 2015 Jun;20:653-64

Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10.
Ruiz FX, Cousido-Siah A, Porté S, Domínguez M, Crespo I, Rechlin C, Mitschler A, de Lera ÁR, Martín MJ, de la Fuente JÁ, Klebe G, Parés X, Farrés J, Podjarny A
ChemMedChem 2015 Dec;10:1989-2003

Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork.
Richet N, Liu D, Legrand P, Velours C, Corpet A, Gaubert A, Bakail M, Moal-Raisin G, Guerois R, Compper C, Besle A, Guichard B, Almouzni G, Ochsenbein F
Nucleic Acids Res 2015 Feb 18;43:1905-17

Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7.
Uchikawa E, Natchiar KS, Han X, Proux F, Roblin P, Zhang E, Durand A, Klaholz BP, Dock-Bregeon AC
Nucleic Acids Res 2015 Mar 31;43:3373-88

Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter.
Gerlach P, Malet H, Cusack S, Reguera J
Cell 2015 Jun 4;161:1267-79

Structural virology. Near-atomic cryo-EM structure of the helical measles virus nucleocapsid.
Gutsche I, Desfosses A, Effantin G, Ling WL, Haupt M, Ruigrok RW, Sachse C, Schoehn G
Science 2015 May 8;348:704-7

Structure Analysis Uncovers a Highly Diverse but Structurally Conserved Effector Family in Phytopathogenic Fungi.
de Guillen K, Ortiz-Vallejo D, Gracy J, Fournier E, Kroj T, Padilla A
PLoS Pathog 2015 Oct;11:e1005228

Structure and Conformation of the Carotenoids in Human Retinal Macular Pigment.
Arteni AA, Fradot M, Galzerano D, Mendes-Pinto MM, Sahel JA, Picaud S, Robert B, Pascal AA
PLoS One 2015 ;10:e0135779

Structure and dynamics of the MKK7-JNK signaling complex.
Kragelj J, Palencia A, Nanao MH, Maurin D, Bouvignies G, Blackledge M, Jensen MR
Proc Natl Acad Sci U S A 2015 Mar 17;112:3409-14

Structure and function insights into the NuRD chromatin remodeling complex.
Torchy MP, Hamiche A, Klaholz BP
Cell Mol Life Sci 2015 Jul;72:2491-507

Structure and primase-mediated activation of a bacterial dodecameric replicative helicase.
Bazin A, Cherrier MV, Gutsche I, Timmins J, Terradot L
Nucleic Acids Res 2015 Sep 30;43:8564-76

Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification.
Kolaj-Robin O, McEwen AG, Cavarelli J, Séraphin B
FEBS J 2015 Mar;282:819-33

Structure of the human 80S ribosome.
Khatter H, Myasnikov AG, Natchiar SK, Klaholz BP
Nature 2015 Apr 30;520:640-5

Structure of the low pH conformation of Chandipura virus G reveals important features in the evolution of the vesiculovirus glycoprotein.
Baquero E, Albertini AA, Raux H, Buonocore L, Rose JK, Bressanelli S, Gaudin Y
PLoS Pathog 2015 Mar;11:e1004756

Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase.
Giménez-Dejoz J, Kolář MH, Ruiz FX, Crespo I, Cousido-Siah A, Podjarny A, Barski OA, Fanfrlík J, Parés X, Farrés J, Porté S
PLoS One 2015 ;10:e0134506

Successive light-induced two electron transfers in a Ru-Fe supramolecular assembly: from Ru-Fe(ii)-OH2 to Ru-Fe(iv)-oxo.
Herrero C, Quaranta A, Sircoglou M, Sénéchal-David K, Baron A, Marín IM, Buron C, Baltaze JP, Leibl W, Aukauloo A, Banse F
Chem Sci 2015 Apr 16;6:2323-2327

Synergistic "ping-pong" energy transfer for efficient light activation in a chromophore-catalyst dyad.
Quaranta A, Charalambidis G, Herrero C, Margiola S, Leibl W, Coutsolelos A, Aukauloo A
Phys Chem Chem Phys 2015 Oct 7;17:24166-72

Synthesis, characterization and biological activity of Cu(II), Zn(II) and Re(I) complexes derived from S-benzyldithiocarbazate and 3-acetylcoumarin.
Low ML, Paulus G, Dorlet P, Guillot R, Rosli R, Delsuc N, Crouse KA, Policar C
Biometals 2015 Jun;28:553-66

Tail proteins of phage T5: investigation of the effect of the His6-tag position, from expression to crystallisation.
Noirclerc-Savoye M, Flayhan A, Pereira C, Gallet B, Gans P, Ebel C, Breyton C
Protein Expr Purif 2015 May;109:70-8

The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli.
Zhang W, Collinet B, Perrochia L, Durand D, van Tilbeurgh H
Nucleic Acids Res 2015 Feb 18;43:1804-17

The crystal structure of the global anaerobic transcriptional regulator FNR explains its extremely fine-tuned monomer-dimer equilibrium.
Volbeda A, Darnault C, Renoux O, Nicolet Y, Fontecilla-Camps JC
Sci Adv 2015 Dec;1:e1501086

The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila.
Jacomin AC, Bescond A, Soleilhac E, Gallet B, Schoehn G, Fauvarque MO, Taillebourg E
PLoS One 2015 ;10:e0143078

The Disordered Region of the HCV Protein NS5A: Conformational Dynamics, SH3 Binding, and Phosphorylation.
Sólyom Z, Ma P, Schwarten M, Bosco M, Polidori A, Durand G, Willbold D, Brutscher B
Biophys J 2015 Oct 6;109:1483-96

The effect of gamma-ray irradiation on the Mn(II) speciation in Deinococcus radiodurans and the potential role of Mn(II)-orthophosphates.
Bruch EM, de Groot A, Un S, Tabares LC
Metallomics 2015 May;7:908-16

The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition.
Fanfrlík J, Ruiz FX, Kadlčíková A, Řezáč J, Cousido-Siah A, Mitschler A, Haldar S, Lepšík M, Kolář MH, Majer P, Podjarny AD, Hobza P
ACS Chem Biol 2015 Jul 17;10:1637-42

The interaction of heparan sulfate proteoglycans with endothelial transglutaminase-2 limits VEGF165-induced angiogenesis.
Beckouche N, Bignon M, Lelarge V, Mathivet T, Pichol-Thievend C, Berndt S, Hardouin J, Garand M, Ardidie-Robouant C, Barret A, Melino G, Lortat-Jacob H, Muller L, Monnot C, Germain S
Sci Signal 2015 Jul 14;8:ra70

The production of multiprotein complexes in insect cells using the baculovirus expression system.
Abdulrahman W, Radu L, Garzoni F, Kolesnikova O, Gupta K, Osz-Papai J, Berger I, Poterszman A
Methods Mol Biol 2015 ;1261:91-114

The SH3 regulatory domain of the hematopoietic cell kinase Hck binds ELMO via its polyproline motif.
Awad R, Sévajol M, Ayala I, Chouquet A, Frachet P, Gans P, Reiser JB, Kleman JP
FEBS Open Bio 2015 ;5:99-106

Toxoplasma gondii: biochemical and biophysical characterization of recombinant soluble dense granule proteins GRA2 and GRA6.
Bittame A, Effantin G, Pètre G, Ruffiot P, Travier L, Schoehn G, Weissenhorn W, Cesbron-Delauw MF, Gagnon J, Mercier C
Biochem Biophys Res Commun 2015 Mar 27;459:107-12

Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution.
Bianchin A, Allemand F, Bell A, Chubb AJ, Guichou JF
Acta Crystallogr D Biol Crystallogr 2015 Jun;71:1319-27

Variations in Mn(II) speciation among organisms: what makes D. radiodurans different.
Bruch EM, Thomine S, Tabares LC, Un S
Metallomics 2015 Jan;7:136-44

Vpu Exploits the Cross-Talk between BST2 and the ILT7 Receptor to Suppress Anti-HIV-1 Responses by Plasmacytoid Dendritic Cells.
Bego MG, Côté É, Aschman N, Mercier J, Weissenhorn W, Cohen ÉA
PLoS Pathog 2015 Jul;11:e1005024

X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form.
Leone P, Bebeacua C, Opota O, Kellenberger C, Klaholz B, Orlov I, Cambillau C, Lemaitre B, Roussel A
J Biol Chem 2015 May 22;290:13191-201

2014 publications

6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities.
Amiable C, Paoletti J, Haouz A, Padilla A, Labesse G, Kaminski PA, Pochet S
Eur J Med Chem 2014 Oct 6;85:418-37

A comprehensive study of small non-frameshift insertions/deletions in proteins and prediction of their phenotypic effects by a machine learning method (KD4i).
Bermejo-Das-Neves C, Nguyen HN, Poch O, Thompson JD
BMC Bioinformatics 2014 Apr 17;15:111

Aedesin: structure and antimicrobial activity against multidrug resistant bacterial strains.
Godreuil S, Leban N, Padilla A, Hamel R, Luplertlop N, Chauffour A, Vittecoq M, Hoh F, Thomas F, Sougakoff W, Lionne C, Yssel H, Missé D
PLoS One 2014 ;9:e105441

A fully enzymatic method for site-directed spin labeling of long RNA.
Lebars I, Vileno B, Bourbigot S, Turek P, Wolff P, Kieffer B
Nucleic Acids Res 2014 Sep;42:e117

A high-yield co-expression system for the purification of an intact Drs2p-Cdc50p lipid flippase complex, critically dependent on and stabilized by phosphatidylinositol-4-phosphate.
Azouaoui H, Montigny C, Ash MR, Fijalkowski F, Jacquot A, Grønberg C, López-Marqués RL, Palmgren MG, Garrigos M, le Maire M, Decottignies P, Gourdon P, Nissen P, Champeil P, Lenoir G
PLoS One 2014 ;9:e112176

Analysis of relationships between peptide/MHC structural features and naive T cell frequency in humans.
Reiser JB, Legoux F, Gras S, Trudel E, Chouquet A, Léger A, Le Gorrec M, Machillot P, Bonneville M, Saulquin X, Housset D
J Immunol 2014 Dec 15;193:5816-26

ANP32E is a histone chaperone that removes H2A.Z from chromatin.
Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A
Nature 2014 Jan 30;505:648-53

Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions.
Turapov O, Waddell SJ, Burke B, Glenn S, Sarybaeva AA, Tudo G, Labesse G, Young DI, Young M, Andrew PW, Butcher PD, Cohen-Gonsaud M, Mukamolova GV
Antimicrob Agents Chemother 2014 May;58:2798-806

Atomic model of a cell-wall cross-linking enzyme in complex with an intact bacterial peptidoglycan.
Schanda P, Triboulet S, Laguri C, Bougault CM, Ayala I, Callon M, Arthur M, Simorre JP
J Am Chem Soc 2014 Dec 24;136:17852-60

ATP binding turns plant cryptochrome into an efficient natural photoswitch.
Müller P, Bouly JP, Hitomi K, Balland V, Getzoff ED, Ritz T, Brettel K
Sci Rep 2014 Jun 5;4:5175

Automated classification of tailed bacteriophages according to their neck organization.
Lopes A, Tavares P, Petit MA, Guérois R, Zinn-Justin S
BMC Genomics 2014 Nov 27;15:1027

Biophysical characterization of the outer membrane polysaccharide export protein and the polysaccharide co-polymerase protein from Xanthomonas campestris.
Bianco MI, Jacobs M, Salinas SR, Salvay AG, Ielmini MV, Ielpi L
Protein Expr Purif 2014 Sep;101:42-53

Carbon dioxide reduction via light activation of a ruthenium-Ni(cyclam) complex.
Herrero C, Quaranta A, El Ghachtouli S, Vauzeilles B, Leibl W, Aukauloo A
Phys Chem Chem Phys 2014 Jun 28;16:12067-72

Chromatin insulator factors involved in long-range DNA interactions and their role in the folding of the Drosophila genome.
Vogelmann J, Le Gall A, Dejardin S, Allemand F, Gamot A, Labesse G, Cuvier O, Nègre N, Cohen-Gonsaud M, Margeat E, Nöllmann M
PLoS Genet 2014 Aug;10:e1004544

Cloning, expression, purification and preliminary X-ray crystallographic analysis of mouse protein arginine methyltransferase 7.
Cura V, Troffer-Charlier N, Lambert MA, Bonnefond L, Cavarelli J
Acta Crystallogr F Struct Biol Commun 2014 Jan;70:80-6

Coiled-coil deformations in crystal structures: the measles virus phosphoprotein multimerization domain as an illustrative example.
Blocquel D, Habchi J, Durand E, Sevajol M, Ferron F, Erales J, Papageorgiou N, Longhi S
Acta Crystallogr D Biol Crystallogr 2014 Jun;70:1589-603

Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains.
Guilligay D, Kadlec J, Crépin T, Lunardi T, Bouvier D, Kochs G, Ruigrok RW, Cusack S
PLoS One 2014 ;9:e84973

Conformational plasticity of the Ebola virus matrix protein.
Radzimanowski J, Effantin G, Weissenhorn W
Protein Sci 2014 Nov;23:1519-27

Conjugation of a new series of dithiocarbazate Schiff base Copper(II) complexes with vectors selected to enhance antibacterial activity.
Low ML, Maigre L, Dorlet P, Guillot R, Pagès JM, Crouse KA, Policar C, Delsuc N
Bioconjug Chem 2014 Dec 17;25:2269-84

Cryo-electron microscopy structure of lactococcal siphophage 1358 virion.
Spinelli S, Bebeacua C, Orlov I, Tremblay D, Klaholz BP, Moineau S, Cambillau C
J Virol 2014 Aug;88:8900-10

Crystallization of the carboxy-terminal region of the bacteriophage T4 proximal long tail fibre protein gp34.
Granell M, Namura M, Alvira S, Garcia-Doval C, Singh AK, Gutsche I, van Raaij MJ, Kanamaru S
Acta Crystallogr F Struct Biol Commun 2014 Jul;70:970-5

Crystal structure and self-interaction of the type VI secretion tail-tube protein from enteroaggregative Escherichia coli.
Douzi B, Spinelli S, Blangy S, Roussel A, Durand E, Brunet YR, Cascales E, Cambillau C
PLoS One 2014 ;9:e86918

Crystal structure of Escherichia coli-expressed Haloarcula marismortui bacteriorhodopsin I in the trimeric form.
Shevchenko V, Gushchin I, Polovinkin V, Round E, Borshchevskiy V, Utrobin P, Popov A, Balandin T, Büldt G, Gordeliy V
PLoS One 2014 ;9:e112873

Crystal structure of pb9, the distal tail protein of bacteriophage T5: a conserved structural motif among all siphophages.
Flayhan A, Vellieux FM, Lurz R, Maury O, Contreras-Martel C, Girard E, Boulanger P, Breyton C
J Virol 2014 Jan;88:820-8

Crystal structure of tryptophan lyase (NosL): evidence for radical formation at the amino group of tryptophan.
Nicolet Y, Zeppieri L, Amara P, Fontecilla-Camps JC
Angew Chem Int Ed Engl 2014 Oct 27;53:11840-4

Deciphering thylakoid sub-compartments using a mass spectrometry-based approach.
Tomizioli M, Lazar C, Brugière S, Burger T, Salvi D, Gatto L, Moyet L, Breckels LM, Hesse AM, Lilley KS, Seigneurin-Berny D, Finazzi G, Rolland N, Ferro M
Mol Cell Proteomics 2014 Aug;13:2147-67

Difference in cytokine production and cell cycle progression induced by Epstein-Barr virus Lmp1 deletion variants in Kmh2, a Hodgkin lymphoma cell line.
Sueur C, Lupo J, Mas P, Morand P, Boyer V
Virol J 2014 May 19;11:94

Direct evidence for a peroxide intermediate and a reactive enzyme-substrate-dioxygen configuration in a cofactor-free oxidase.
Bui S, von Stetten D, Jambrina PG, Prangé T, Colloc'h N, de Sanctis D, Royant A, Rosta E, Steiner RA
Angew Chem Int Ed Engl 2014 Dec 8;53:13710-4

Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation.
Kannan S, Melesina J, Hauser AT, Chakrabarti A, Heimburg T, Schmidtkunz K, Walter A, Marek M, Pierce RJ, Romier C, Jung M, Sippl W
J Chem Inf Model 2014 Oct 27;54:3005-19

DNA binding by Sgf11 protein affects histone H2B deubiquitination by Spt-Ada-Gcn5-acetyltransferase (SAGA).
Koehler C, Bonnet J, Stierle M, Romier C, Devys D, Kieffer B
J Biol Chem 2014 Mar 28;289:8989-99

Efficient denoising algorithms for large experimental datasets and their applications in Fourier transform ion cyclotron resonance mass spectrometry.
Chiron L, van Agthoven MA, Kieffer B, Rolando C, Delsuc MA
Proc Natl Acad Sci U S A 2014 Jan 28;111:1385-90

Elongated structure of the outer-membrane activator of peptidoglycan synthesis LpoA: implications for PBP1A stimulation.
Jean NL, Bougault CM, Lodge A, Derouaux A, Callens G, Egan AJ, Ayala I, Lewis RJ, Vollmer W, Simorre JP
Structure 2014 Jul 8;22:1047-54

Evolution of protein interactions: from interactomes to interfaces.
Andreani J, Guerois R
Arch Biochem Biophys 2014 Jul 15;554:65-75

Expression, purification and crystallization of two endonuclease III enzymes from Deinococcus radiodurans.
Sarre A, Ökvist M, Klar T, Moe E, Timmins J
Acta Crystallogr F Struct Biol Commun 2014 Dec 1;70:1688-92

Fermi resonance as a tool for probing peridinin environment.
Kish E, Mendes Pinto MM, Bovi D, Basire M, Guidoni L, Vuilleumier R, Robert B, Spezia R, Mezzetti A
J Phys Chem B 2014 Jun 5;118:5873-81

Formation of circular polyribosomes on eukaryotic mRNA without cap-structure and poly(A)-tail: a cryo electron tomography study.
Afonina ZA, Myasnikov AG, Shirokov VA, Klaholz BP, Spirin AS
Nucleic Acids Res 2014 Aug;42:9461-9

Functional and structural analysis of HicA3-HicB3, a novel toxin-antitoxin system of Yersinia pestis.
Bibi-Triki S, Li de la Sierra-Gallay I, Lazar N, Leroy A, Van Tilbeurgh H, Sebbane F, Pradel E
J Bacteriol 2014 Nov;196:3712-23

High throughput quantitative expression screening and purification applied to recombinant disulfide-rich venom proteins produced in E. coli.
Saez NJ, Nozach H, Blemont M, Vincentelli R
J Vis Exp 2014 Jul 30;:e51464

HNCA+, HNCO+, and HNCACB+ experiments: improved performance by simultaneous detection of orthogonal coherence transfer pathways.
Gil-Caballero S, Favier A, Brutscher B
J Biomol NMR 2014 Sep;60:1-9

Homodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity.
Sagnol S, Yang Y, Bessin Y, Allemand F, Hapkova I, Notarnicola C, Guichou JF, Faure S, Labesse G, de Santa Barbara P
Nucleic Acids Res 2014 Sep;42:10173-84

Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit.
Meurisse J, Bacquin A, Richet N, Charbonnier JB, Ochsenbein F, Peyroche A
Nucleic Acids Res 2014 Dec 1;42:13174-85

Human ficolin-2 recognition versatility extended: an update on the binding of ficolin-2 to sulfated/phosphated carbohydrates.
Laffly E, Lacroix M, Martin L, Vassal-Stermann E, Thielens NM, Gaboriaud C
FEBS Lett 2014 Dec 20;588:4694-700

Human full-length coagulation factor X and a GLA domain-derived 40-mer polypeptide bind to different regions of the adenovirus serotype 5 hexon capsomer.
Sumarheni S, Hong SS, Josserand V, Coll JL, Boulanger P, Schoehn G, Fender P
Hum Gene Ther 2014 Apr;25:339-49

Human L-ficolin recognizes phosphocholine moieties of pneumococcal teichoic acid.
Vassal-Stermann E, Lacroix M, Gout E, Laffly E, Pedersen CM, Martin L, Amoroso A, Schmidt RR, Zähringer U, Gaboriaud C, Di Guilmi AM, Thielens NM
J Immunol 2014 Dec 1;193:5699-708

Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design.
Cousido-Siah A, Ruiz FX, Mitschler A, Porté S, de Lera ÁR, Martín MJ, Manzanaro S, de la Fuente JA, Terwesten F, Betz M, Klebe G, Farrés J, Parés X, Podjarny A
Acta Crystallogr D Biol Crystallogr 2014 Mar;70:889-903

Insights into bacteriophage T5 structure from analysis of its morphogenesis genes and protein components.
Zivanovic Y, Confalonieri F, Ponchon L, Lurz R, Chami M, Flayhan A, Renouard M, Huet A, Decottignies P, Davidson AR, Breyton C, Boulanger P
J Virol 2014 Jan;88:1162-74

Intrinsic disorder within the erythrocyte binding-like proteins from Plasmodium falciparum.
Blanc M, Coetzer TL, Blackledge M, Haertlein M, Mitchell EP, Forsyth VT, Jensen MR
Biochim Biophys Acta 2014 Dec;1844:2306-14

Investigating macromolecular complexes using top-down mass spectrometry.
Boeri Erba E
Proteomics 2014 May;14:1259-70

Kinetic studies of a ferredoxin-dependent cyanobacterial nitrate reductase.
Srivastava AP, Knaff DB, Sétif P
Biochemistry 2014 Aug 12;53:5092-101

Lipid interactions of LAH4, a peptide with antimicrobial and nucleic acid transfection activities.
Perrone B, Miles AJ, Salnikov ES, Wallace BA, Bechinger B
Eur Biophys J 2014 Nov;43:499-507

Mapping the deubiquitination module within the SAGA complex.
Durand A, Bonnet J, Fournier M, Chavant V, Schultz P
Structure 2014 Nov 4;22:1553-9

Measuring hydrogen exchange in proteins by selective water saturation in (1)H- (15)N SOFAST/BEST-type experiments: advantages and limitations.
Rennella E, Solyom Z, Brutscher B
J Biomol NMR 2014 Nov;60:99-107

Measuring residual dipolar couplings at high hydrostatic pressure: robustness of alignment media to high pressure.
Sibille N, Dellarole M, Royer C, Roumestand C
J Biomol NMR 2014 Jan;58:9-16

Membrane and chaperone recognition by the major translocator protein PopB of the type III secretion system of Pseudomonas aeruginosa.
Discola KF, Förster A, Boulay F, Simorre JP, Attree I, Dessen A, Job V
J Biol Chem 2014 Feb 7;289:3591-601

Metrics for comparison of crystallographic maps.
Urzhumtsev A, Afonine PV, Lunin VY, Terwilliger TC, Adams PD
Acta Crystallogr D Biol Crystallogr 2014 Oct;70:2593-606

Modulators of vitamin D nuclear receptor: recent advances from structural studies.
Belorusova AY, Rochel N
Curr Top Med Chem 2014 ;14:2368-77

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.
Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M
J Mol Biol 2014 Oct 9;426:3442-53

Molecular determinants of the DprA-RecA interaction for nucleation on ssDNA.
Lisboa J, Andreani J, Sanchez D, Boudes M, Collinet B, Liger D, van Tilbeurgh H, Guérois R, Quevillon-Cheruel S
Nucleic Acids Res 2014 Jun;42:7395-408

Molecular insights on the recognition of a Lactococcus lactis cell wall pellicle by the phage 1358 receptor binding protein.
Farenc C, Spinelli S, Vinogradov E, Tremblay D, Blangy S, Sadovskaya I, Moineau S, Cambillau C
J Virol 2014 Jun;88:7005-15

Nanoparticle surface-enhanced Raman scattering of bacteriorhodopsin stabilized by amphipol A8-35.
Polovinkin V, Balandin T, Volkov O, Round E, Borshchevskiy V, Utrobin P, von Stetten D, Royant A, Willbold D, Arzumanyan G, Chupin V, Popot JL, Gordeliy V
J Membr Biol 2014 Oct;247:971-80

Nuclear position dictates DNA repair pathway choice.
Lemaître C, Grabarz A, Tsouroula K, Andronov L, Furst A, Pankotai T, Heyer V, Rogier M, Attwood KM, Kessler P, Dellaire G, Klaholz B, Reina-San-Martin B, Soutoglou E
Genes Dev 2014 Nov 15;28:2450-63

Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B.
Egan AJ, Jean NL, Koumoutsi A, Bougault CM, Biboy J, Sassine J, Solovyova AS, Breukink E, Typas A, Vollmer W, Simorre JP
Proc Natl Acad Sci U S A 2014 Jun 3;111:8197-202

Photosynthesis. Electronic structure of the oxygen-evolving complex in photosystem II prior to O-O bond formation.
Cox N, Retegan M, Neese F, Pantazis DA, Boussac A, Lubitz W
Science 2014 Aug 15;345:804-8

Probing the conformation of FhaC with small-angle neutron scattering and molecular modeling.
Gabel F, Lensink MF, Clantin B, Jacob-Dubuisson F, Villeret V, Ebel C
Biophys J 2014 Jul 1;107:185-96

Probing transient conformational states of proteins by solid-state R(1ρ) relaxation-dispersion NMR spectroscopy.
Ma P, Haller JD, Zajakala J, Macek P, Sivertsen AC, Willbold D, Boisbouvier J, Schanda P
Angew Chem Int Ed Engl 2014 Apr 22;53:4312-7

Production and characterization of a retinoic acid receptor RARγ construction encompassing the DNA binding domain and the disordered N-terminal proline rich domain.
Martinez-Zapien D, Delsuc MA, Travé G, Lutzing R, Rochette-Egly C, Kieffer B
Protein Expr Purif 2014 Mar;95:113-20

Purification, characterization and crystallization of the human 80S ribosome.
Khatter H, Myasnikov AG, Mastio L, Billas IM, Birck C, Stella S, Klaholz BP
Nucleic Acids Res 2014 Apr;42:e49

Restricted diversity of antigen binding residues of antibodies revealed by computational alanine scanning of 227 antibody-antigen complexes.
Robin G, Sato Y, Desplancq D, Rochel N, Weiss E, Martineau P
J Mol Biol 2014 Nov 11;426:3729-43

Reversible amyloid fiber formation in the N terminus of androgen receptor.
Asencio-Hernández J, Ruhlmann C, McEwen A, Eberling P, Nominé Y, Céraline J, Starck JP, Delsuc MA
Chembiochem 2014 Nov 3;15:2370-3

Robust and low cost uniform (15)N-labeling of proteins expressed in Drosophila S2 cells and Spodoptera frugiperda Sf9 cells for NMR applications.
Meola A, Deville C, Jeffers SA, Guardado-Calvo P, Vasiliauskaite I, Sizun C, Girard-Blanc C, Malosse C, van Heijenoort C, Chamot-Rooke J, Krey T, Guittet E, Pêtres S, Rey FA, Bontems F
J Struct Biol 2014 Oct;188:71-8

Structural and functional analysis of the fibronectin-binding protein FNE from Streptococcus equi spp. equi.
Tiouajni M, Durand D, Blondeau K, Graille M, Urvoas A, Valerio-Lepiniec M, Guellouz A, Aumont-Nicaise M, Minard P, van Tilbeurgh H
FEBS J 2014 Dec;281:5513-31

Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition.
Cocaign A, Kubiak X, Xu X, Garnier G, Li de la Sierra-Gallay I, Chi-Bui L, Dairou J, Busi F, Abuhammad A, Haouz A, Dupret JM, Herrmann JL, Rodrigues-Lima F
Acta Crystallogr D Biol Crystallogr 2014 Nov;70:3066-79

Structural and functional characterization of the Clostridium perfringens N-acetylmannosamine-6-phosphate 2-epimerase essential for the sialic acid salvage pathway.
Pélissier MC, Sebban-Kreuzer C, Guerlesquin F, Brannigan JA, Bourne Y, Vincent F
J Biol Chem 2014 Dec 19;289:35215-24

Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA.
Lebreton A, Job V, Ragon M, Le Monnier A, Dessen A, Cossart P, Bierne H
MBio 2014 Jan 21;5:e00775-13

Structural basis for the oligomerization of the MADS domain transcription factor SEPALLATA3 in Arabidopsis.
Puranik S, Acajjaoui S, Conn S, Costa L, Conn V, Vial A, Marcellin R, Melzer R, Brown E, Hart D, Theißen G, Silva CS, Parcy F, Dumas R, Nanao M, Zubieta C
Plant Cell 2014 Sep;26:3603-15

Structural basis of pilus anchoring by the ancillary pilin RrgC of Streptococcus pneumoniae.
Shaik MM, Maccagni A, Tourcier G, Di Guilmi AM, Dessen A
J Biol Chem 2014 Jun 13;289:16988-97

Structural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active site.
Cura V, Troffer-Charlier N, Wurtz JM, Bonnefond L, Cavarelli J
Acta Crystallogr D Biol Crystallogr 2014 Sep;70:2401-12

Structural insights into the dimerization of the response regulator ComE from Streptococcus pneumoniae.
Boudes M, Sanchez D, Graille M, van Tilbeurgh H, Durand D, Quevillon-Cheruel S
Nucleic Acids Res 2014 Apr;42:5302-13

Structural insights into the molecular mechanism of vitamin D receptor activation by lithocholic acid involving a new mode of ligand recognition.
Belorusova AY, Eberhardt J, Potier N, Stote RH, Dejaegere A, Rochel N
J Med Chem 2014 Jun 12;57:4710-9

Structural similarity of secretins from type II and type III secretion systems.
Tosi T, Estrozi LF, Job V, Guilvout I, Pugsley AP, Schoehn G, Dessen A
Structure 2014 Sep 2;22:1348-1355

Structure, ligands and substrate coordination of the oxygen-evolving complex of photosystem II in the S2 state: a combined EPR and DFT study.
Lohmiller T, Krewald V, Navarro MP, Retegan M, Rapatskiy L, Nowaczyk MM, Boussac A, Neese F, Lubitz W, Pantazis DA, Cox N
Phys Chem Chem Phys 2014 Jun 28;16:11877-92

Structure of a bacterial α2-macroglobulin reveals mimicry of eukaryotic innate immunity.
Wong SG, Dessen A
Nat Commun 2014 Sep 15;5:4917

Structure of Nipah virus unassembled nucleoprotein in complex with its viral chaperone.
Yabukarski F, Lawrence P, Tarbouriech N, Bourhis JM, Delaforge E, Jensen MR, Ruigrok RW, Blackledge M, Volchkov V, Jamin M
Nat Struct Mol Biol 2014 Sep;21:754-9

Structures of a human blood group glycosyltransferase in complex with a photo-activatable UDP-Gal derivative reveal two different binding conformations.
Jørgensen R, Batot G, Mannerstedt K, Imberty A, Breton C, Hindsgaul O, Royant A, Palcic MM
Acta Crystallogr F Struct Biol Commun 2014 Aug;70:1015-21

Substrate-water exchange in photosystem II is arrested before dioxygen formation.
Nilsson H, Rappaport F, Boussac A, Messinger J
Nat Commun 2014 Jul 4;5:4305

The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold.
Schulte T, Löfling J, Mikaelsson C, Kikhney A, Hentrich K, Diamante A, Ebel C, Normark S, Svergun D, Henriques-Normark B, Achour A
Open Biol 2014 Jan 15;4:130090

The cooperative function of arginine residues in the Prototype Foamy Virus Gag C-terminus mediates viral and cellular RNA encapsidation.
Hamann MV, Müllers E, Reh J, Stanke N, Effantin G, Weissenhorn W, Lindemann D
Retrovirology 2014 Oct 8;11:87

The crystal structure of Fe₄S₄ quinolinate synthase unravels an enzymatic dehydration mechanism that uses tyrosine and a hydrolase-type triad.
Cherrier MV, Chan A, Darnault C, Reichmann D, Amara P, Ollagnier de Choudens S, Fontecilla-Camps JC
J Am Chem Soc 2014 Apr 9;136:5253-6

The crystal structure of the anti-σ factor CnrY in complex with the σ factor CnrH shows a new structural class of anti-σ factors targeting extracytoplasmic function σ factors.
Maillard AP, Girard E, Ziani W, Petit-Härtlein I, Kahn R, Covès J
J Mol Biol 2014 Jun 12;426:2313-27

The Cyanobacterial Photoactive Orange Carotenoid Protein Is an Excellent Singlet Oxygen Quencher.
Sedoud A, López-Igual R, Ur Rehman A, Wilson A, Perreau F, Boulay C, Vass I, Krieger-Liszkay A, Kirilovsky D
Plant Cell 2014 Apr;26:1781-1791

The D1-173 amino acid is a structural determinant of the critical interaction between D1-Tyr161 (TyrZ) and D1-His190 in Photosystem II.
Sugiura M, Ozaki Y, Nakamura M, Cox N, Rappaport F, Boussac A
Biochim Biophys Acta 2014 Dec;1837:1922-1931

The effect of myoglobin crowding on the dynamics of water: an infrared study.
Le Caër S, Klein G, Ortiz D, Lima M, Devineau S, Pin S, Brubach JB, Roy P, Pommeret S, Leibl W, Righini R, Renault JP
Phys Chem Chem Phys 2014 Nov 7;16:22841-52

The elongation of ovococci.
Philippe J, Vernet T, Zapun A
Microb Drug Resist 2014 Jun;20:215-21

The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes.
Myasnikov AG, Afonina ZA, Ménétret JF, Shirokov VA, Spirin AS, Klaholz BP
Nat Commun 2014 Nov 7;5:5294

The palindromic DNA-bound USP/EcR nuclear receptor adopts an asymmetric organization with allosteric domain positioning.
Maletta M, Orlov I, Roblin P, Beck Y, Moras D, Billas IM, Klaholz BP
Nat Commun 2014 Jun 19;5:4139

The RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation-promoting factor catalytic domain.
Chauviac FX, Robertson G, Quay DH, Bagnéris C, Dumas C, Henderson B, Ward J, Keep NH, Cohen-Gonsaud M
Acta Crystallogr F Struct Biol Commun 2014 Aug;70:1022-6

The stoichiometry of scaffold complexes in living neurons - DLC2 functions as a dimerization engine for GKAP.
Moutin E, Compan V, Raynaud F, Clerté C, Bouquier N, Labesse G, Ferguson ML, Fagni L, Royer CA, Perroy J
J Cell Sci 2014 Aug 15;127:3451-62

The TET2 and TET3 aminopeptidases from Pyrococcus horikoshii form a hetero-subunit peptidasome with enhanced peptide destruction properties.
Appolaire A, Durá MA, Ferruit M, Andrieu JP, Godfroy A, Gribaldo S, Franzetti B
Mol Microbiol 2014 Nov;94:803-14

2013 publications

Allosteric controls of nuclear receptor function in the regulation of transcription.
Billas I, Moras D
J Mol Biol 2013 Jul 10;425:2317-29

Assessing the conformational changes of pb5, the receptor-binding protein of phage T5, upon binding to its Escherichia coli receptor FhuA.
Breyton C, Flayhan A, Gabel F, Lethier M, Durand G, Boulanger P, Chami M, Ebel C
J Biol Chem 2013 Oct 18;288:30763-72

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
Le Rouzic E, Bonnard D, Chasset S, Bruneau JM, Chevreuil F, Le Strat F, Nguyen J, Beauvoir R, Amadori C, Brias J, Vomscheid S, Eiler S, Lévy N, Delelis O, Deprez E, Saïb A, Zamborlini A, Emiliani S, Ruff M, Ledoussal B, Moreau F, Benarous R
Retrovirology 2013 Nov 21;10:144

EPR characterisation of the ferrous nitrosyl complex formed within the oxygenase domain of NO synthase.
Santolini J, Maréchal A, Boussac A, Dorlet P
Chembiochem 2013 Sep 23;14:1852-7

Escherichia coli ribosomal protein S1 unfolds structured mRNAs onto the ribosome for active translation initiation.
Duval M, Korepanov A, Fuchsbauer O, Fechter P, Haller A, Fabbretti A, Choulier L, Micura R, Klaholz BP, Romby P, Springer M, Marzi S
PLoS Biol 2013 Dec;11:e1001731

Expression in Escherichia coli: becoming faster and more complex.
Vincentelli R, Romier C
Curr Opin Struct Biol 2013 Jun;23:326-34

Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors.
Rouhana J, Hoh F, Estaran S, Henriquet C, Boublik Y, Kerkour A, Trouillard R, Martinez J, Pugnière M, Padilla A, Chavanieu A
J Med Chem 2013 Nov 14;56:8497-511

High throughput screening identifies disulfide isomerase DsbC as a very efficient partner for recombinant expression of small disulfide-rich proteins in E. coli.
Nozach H, Fruchart-Gaillard C, Fenaille F, Beau F, Ramos OH, Douzi B, Saez NJ, Moutiez M, Servent D, Gondry M, Thaï R, Cuniasse P, Vincentelli R, Dive V
Microb Cell Fact 2013 Apr 22;12:37

Identification of a mycoloyl transferase selectively involved in O-acylation of polypeptides in Corynebacteriales.
Huc E, de Sousa-D'Auria C, de la Sierra-Gallay IL, Salmeron C, van Tilbeurgh H, Bayan N, Houssin C, Daffé M, Tropis M
J Bacteriol 2013 Sep;195:4121-8

Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases.
Eiler D, Lin J, Simonetti A, Klaholz BP, Steitz TA
Proc Natl Acad Sci U S A 2013 Sep 24;110:15662-7

InterEvScore: a novel coarse-grained interface scoring function using a multi-body statistical potential coupled to evolution.
Andreani J, Faure G, Guerois R
Bioinformatics 2013 Jul 15;29:1742-9

In vitro reconstitution of peptidoglycan assembly from the Gram-positive pathogen Streptococcus pneumoniae.
Zapun A, Philippe J, Abrahams KA, Signor L, Roper DI, Breukink E, Vernet T
ACS Chem Biol 2013 Dec 20;8:2688-96

Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.
Simonetti A, Marzi S, Billas IM, Tsai A, Fabbretti A, Myasnikov AG, Roblin P, Vaiana AC, Hazemann I, Eiler D, Steitz TA, Puglisi JD, Gualerzi CO, Klaholz BP
Proc Natl Acad Sci U S A 2013 Sep 24;110:15656-61

Lamination and spherulite-like compaction of a hormone's native amyloid-like nanofibrils: spectroscopic insights into key interactions.
van Grondelle W, Lecomte S, Lopez-Iglesias C, Manero JM, Cherif-Cheikh R, Paternostre M, Valéry C
Faraday Discuss 2013 ;166:163-80

TLS from fundamentals to practice.
Urzhumtsev A, Afonine PV, Adams PD
Crystallogr Rev 2013 Jul 1;19:230-270

Matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometric analysis of intact proteins larger than 100 kDa.
Signor L, Boeri Erba E
J Vis Exp 2013 Sep 9;:

MgATP regulates allostery and fiber formation in IMPDHs.
Labesse G, Alexandre T, Vaupré L, Salard-Arnaud I, Him JL, Raynal B, Bron P, Munier-Lehmann H
Structure 2013 Jun 4;21:975-85

MreB and MurG as scaffolds for the cytoplasmic steps of peptidoglycan biosynthesis.
Favini-Stabile S, Contreras-Martel C, Thielens N, Dessen A
Environ Microbiol 2013 Dec;15:3218-28

N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1.
Amiable C, Pochet S, Padilla A, Labesse G, Kaminski PA
PLoS One 2013 ;8:e80755

Oligomeric states along the folding pathways of β2-microglobulin: kinetics, thermodynamics, and structure.
Rennella E, Cutuil T, Schanda P, Ayala I, Gabel F, Forge V, Corazza A, Esposito G, Brutscher B
J Mol Biol 2013 Aug 9;425:2722-36

On effective and optical resolutions of diffraction data sets.
Urzhumtseva L, Klaholz B, Urzhumtsev A
Acta Crystallogr D Biol Crystallogr 2013 Oct;69:1921-34

Reconstitution of membrane protein complexes involved in pneumococcal septal cell wall assembly.
Noirclerc-Savoye M, Lantez V, Signor L, Philippe J, Vernet T, Zapun A
PLoS One 2013 ;8:e75522

Reconstruction of quaternary structure from X-ray scattering by equilibrium mixtures of biological macromolecules.
Petoukhov MV, Billas IM, Takacs M, Graewert MA, Moras D, Svergun DI
Biochemistry 2013 Oct 1;52:6844-55

SERCA mutant E309Q binds two Ca(2+) ions but adopts a catalytically incompetent conformation.
Clausen JD, Bublitz M, Arnou B, Montigny C, Jaxel C, Møller JV, Nissen P, Andersen JP, le Maire M
EMBO J 2013 Dec 11;32:3231-43

Specific labeling and assignment strategies of valine methyl groups for NMR studies of high molecular weight proteins.
Mas G, Crublet E, Hamelin O, Gans P, Boisbouvier J
J Biomol NMR 2013 Nov;57:251-62

Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad.
Kubiak X, Li de la Sierra-Gallay I, Chaffotte AF, Pluvinage B, Weber P, Haouz A, Dupret JM, Rodrigues-Lima F
J Biol Chem 2013 Aug 2;288:22493-505

Structural and functional characterization of the single-chain Fv fragment from a unique HCV E1E2-specific monoclonal antibody.
Fallecker C, Tarbouriech N, Habib M, Petit MA, Drouet E
FEBS Lett 2013 Oct 11;587:3335-40

Structural and functional role of INI1 and LEDGF in the HIV-1 preintegration complex.
Maillot B, Lévy N, Eiler S, Crucifix C, Granger F, Richert L, Didier P, Godet J, Pradeau-Aubreton K, Emiliani S, Nazabal A, Lesbats P, Parissi V, Mely Y, Moras D, Schultz P, Ruff M
PLoS One 2013 ;8:e60734

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni.
Marek M, Kannan S, Hauser AT, Moraes Mourão M, Caby S, Cura V, Stolfa DA, Schmidtkunz K, Lancelot J, Andrade L, Renaud JP, Oliveira G, Sippl W, Jung M, Cavarelli J, Pierce RJ, Romier C
PLoS Pathog 2013 ;9:e1003645

Structural evidence for a two-regime photobleaching mechanism in a reversibly switchable fluorescent protein.
Duan C, Adam V, Byrdin M, Ridard J, Kieffer-Jaquinod S, Morlot C, Arcizet D, Demachy I, Bourgeois D
J Am Chem Soc 2013 Oct 23;135:15841-50

Structural insight into negative DNA supercoiling by DNA gyrase, a bacterial type 2A DNA topoisomerase.
Papillon J, Ménétret JF, Batisse C, Hélye R, Schultz P, Potier N, Lamour V
Nucleic Acids Res 2013 Sep;41:7815-27

Structure, assembly and dynamics of macromolecular complexes by single particle cryo-electron microscopy.
Durand A, Papai G, Schultz P
J Nanobiotechnology 2013 ;11 Suppl 1:S4

Structure of a truncation mutant of the nuclear export factor CRM1 provides insights into the auto-inhibitory role of its C-terminal helix.
Dian C, Bernaudat F, Langer K, Oliva MF, Fornerod M, Schoehn G, Müller CW, Petosa C
Structure 2013 Aug 6;21:1338-49

Structure of internalin InlK from the human pathogen Listeria monocytogenes.
Neves D, Job V, Dortet L, Cossart P, Dessen A
J Mol Biol 2013 Nov 15;425:4520-9

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.
Delvecchio M, Gaucher J, Aguilar-Gurrieri C, Ortega E, Panne D
Nat Struct Mol Biol 2013 Sep;20:1040-6

Structure of the protein core of translation initiation factor 2 in apo, GTP-bound and GDP-bound forms.
Simonetti A, Marzi S, Fabbretti A, Hazemann I, Jenner L, Urzhumtsev A, Gualerzi CO, Klaholz BP
Acta Crystallogr D Biol Crystallogr 2013 Jun;69:925-33

The asymmetric binding of PGC-1α to the ERRα and ERRγ nuclear receptor homodimers involves a similar recognition mechanism.
Takacs M, Petoukhov MV, Atkinson RA, Roblin P, Ogi FX, Demeler B, Potier N, Chebaro Y, Dejaegere A, Svergun DI, Moras D, Billas IM
PLoS One 2013 ;8:e67810

The multiBac protein complex production platform at the EMBL.
Berger I, Garzoni F, Chaillet M, Haffke M, Gupta K, Aubert A
J Vis Exp 2013 Jul 11;:e50159

The structure of FemX(Wv) in complex with a peptidyl-RNA conjugate: mechanism of aminoacyl transfer from Ala-tRNA(Ala) to peptidoglycan precursors.
Fonvielle M, Li de La Sierra-Gallay I, El-Sagheer AH, Lecerf M, Patin D, Mellal D, Mayer C, Blanot D, Gale N, Brown T, van Tilbeurgh H, Ethève-Quelquejeu M, Arthur M
Angew Chem Int Ed Engl 2013 Jul 8;52:7278-81

TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration.
Rousseau A, McEwen AG, Poussin-Courmontagne P, Rognan D, Nominé Y, Rio MC, Tomasetto C, Alpy F
PLoS Biol 2013 Dec;11:e1001726

Viral infection modulation and neutralization by camelid nanobodies.
Desmyter A, Farenc C, Mahony J, Spinelli S, Bebeacua C, Blangy S, Veesler D, van Sinderen D, Cambillau C
Proc Natl Acad Sci U S A 2013 Apr 9;110:E1371-9

2012 publications

MultiBac complexomics.
Trowitzsch S, Palmberger D, Fitzgerald D, Takagi Y, Berger I
Expert Rev Proteomics 2012 Aug;9:363-73

Solution Structures of PPARγ2/RXRα Complexes.
Osz J, Pethoukhov MV, Sirigu S, Svergun DI, Moras D, Rochel N
PPAR Res 2012 ;2012:701412

2010 publications

PHENIX: a comprehensive Python-based system for macromolecular structure solution.
Adams PD, Afonine PV, Bunkóczi G, Chen VB, Davis IW, Echols N, Headd JJ, Hung LW, Kapral GJ, Grosse-Kunstleve RW, McCoy AJ, Moriarty NW, Oeffner R, Read RJ, Richardson DC, Richardson JS, Terwilliger TC, Zwart PH
Acta Crystallogr D Biol Crystallogr 2010 Feb;66:213-21

1987 publications

[Tolerance of the cardiovascular system of hypothyroidism patients for physical loading].
Sokolov EI, Zaev AP, Ol'kha RP, Sofieva IE, Zhizhina SA
Kardiologiia 1987 Sep;27:80-4

1986 publications

Utilization of cytoplasmic lysozyme immunoreactivity as a histiocytic marker in canine histiocytic disorders.
Moore PF
Vet Pathol 1986 Nov;23:757-62