The next challenge facing structural biologists is to understand biological processes at cellular and organism scales. This is one of the main goals of integrated structural biology, which encompasses a variety of high-tech methods for sample generation and characterisation (e.g. structure determination, complex assembly, dynamics, function and interactions). These studies often require expensive equipment, for example synchrotron beamlines, high-field NMR and electron microscopes, as well as expert knowledge at the interface of biology, physics and chemistry.
The IBS-ISBG FRISBI centre in Grenoble provides supported user access to state of the art structural biology instrumentation in France, notably high level cryoEM and NMR. Our services and technologies address areas of sample preparation, characterisation and structure determination. All platforms have ISO 9001 quality certification. User access to the platforms of the Institut de Biologie Structurale (IBS; www.ibs.fr) is managed by the Integrated Structural Biology Grenoble (ISBG; www.isbg.fr) service unit.
The IBS is located on the EPN Science Campus, an international science hub that also hosts three major European institutes – EMBL, ESRF and ILL, each with major research and user access programs in structural biology.