FRISBI
Ultra high-intensity microfocus rotating anode X-ray generator coupled with a diffractometer for collection of diffraction data from single crystals, and a BioSAXS device for collection of diffusion data from macromolecular solutions. The variable divergence on the optics, coupled with a pixel array detector, allows for the resolution of unit cell dimensions up to 600Å.
Device:
Rigaku FR-X generator coupled with Osmic VariMax HF Arc)Sec Confocal optics and a Dectris Pilatus 300K pixel array detector on the left port, and a Rigaku BioSAXS-1000 system on the right port. This generator has a focal spot size of µm and a power of 2.97kW leading to a brillance of 1.2 x 1010 photons/sec/mm2/mR2. The VariMax Arc)Sec HF optics have a divergence range of 4.8mR - 0mR (by moving the divergence slits) leading to a maximum beam size of 0.19mm.
Structural Basis for DNA Gyrase Interaction with Coumermycin A1. A. Vanden Broeck, A.G. McEwen, Y. Chebaro, N. Potier, V. Lamour. J Med Chem. 2019, 62, 4225-4231.
Modulation of RXR-DNA complex assembly by DNA context. J. Osz, AG. McEwen, J. Wolf et al. & Rochel N. Mol Cell Endocrinol. 2019, 481, 44-52.
Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis. G. Peng, AG. McEwen, V. Olieric et al. & Tarnus C. Proteins 2017, 85, 1413-1421.
Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification. Kolaj-Robin O, McEwen AG, Cavarelli J, Séraphin B. FEBS J. 2015 Mar;282(5):819-33. doi: 10.1111/febs.13199. Epub 2015 Feb 4.